NO992903L - Anvendelse av 7-(2-oksa-5,8-diazabicyklo/4.3.0/non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer - Google Patents

Anvendelse av 7-(2-oksa-5,8-diazabicyklo/4.3.0/non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer

Info

Publication number
NO992903L
NO992903L NO992903A NO992903A NO992903L NO 992903 L NO992903 L NO 992903L NO 992903 A NO992903 A NO 992903A NO 992903 A NO992903 A NO 992903A NO 992903 L NO992903 L NO 992903L
Authority
NO
Norway
Prior art keywords
carboxylic acid
oxa
diazabicyclo
helicobacter pylori
treatment
Prior art date
Application number
NO992903A
Other languages
English (en)
Other versions
NO325617B1 (no
NO992903D0 (no
Inventor
Michael Matzke
Uwe Petersen
Thomas Jaetsch
Stephan Bartel
Thomas Schenke
Thomas Himmler
Bernd Baasner
Hans-Otto Werling
Klaus Schaller
Harald Labischinski
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO992903L publication Critical patent/NO992903L/no
Publication of NO992903D0 publication Critical patent/NO992903D0/no
Publication of NO325617B1 publication Critical patent/NO325617B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19992903A 1996-12-16 1999-06-14 Anvendelse av 7-(2-oksa-5,8-diazabicyklo[4.3.0]non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for fremstilling av legemidler for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer, diastereomerrene og enantiomerrene forbindelser, anvendelse derav samt legemiddel inneholdende disse. NO325617B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19652239A DE19652239A1 (de) 1996-12-16 1996-12-16 Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
PCT/EP1997/006781 WO1998026779A1 (de) 1996-12-16 1997-12-04 Verwendung von 7-(2-oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen

Publications (3)

Publication Number Publication Date
NO992903L true NO992903L (no) 1999-06-14
NO992903D0 NO992903D0 (no) 1999-06-14
NO325617B1 NO325617B1 (no) 2008-06-30

Family

ID=7814837

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19992903A NO325617B1 (no) 1996-12-16 1999-06-14 Anvendelse av 7-(2-oksa-5,8-diazabicyklo[4.3.0]non-8-yl)-kinolonkarboksylsyre og naftyridonkarboksylsyrederivater for fremstilling av legemidler for behandling av helicobacter pylori infeksjoner og dermed forbundede gastroduodenale sykdommer, diastereomerrene og enantiomerrene forbindelser, anvendelse derav samt legemiddel inneholdende disse.

Country Status (28)

Country Link
US (2) US6133260A (no)
EP (1) EP0946176B1 (no)
JP (3) JP3463939B2 (no)
KR (1) KR100536153B1 (no)
CN (1) CN100335054C (no)
AT (1) ATE214929T1 (no)
AU (1) AU717751B2 (no)
BG (1) BG64615B1 (no)
BR (1) BR9714032A (no)
CA (1) CA2274894C (no)
CZ (2) CZ297363B6 (no)
DE (2) DE19652239A1 (no)
DK (1) DK0946176T3 (no)
EA (1) EA002477B1 (no)
EE (1) EE04090B1 (no)
ES (1) ES2175519T3 (no)
HK (1) HK1025517A1 (no)
HU (1) HU226523B1 (no)
IL (1) IL130311A (no)
NO (1) NO325617B1 (no)
NZ (2) NZ336228A (no)
PL (1) PL191193B1 (no)
PT (1) PT946176E (no)
RS (1) RS49684B (no)
SK (2) SK283224B6 (no)
TR (1) TR199901754T2 (no)
UA (1) UA57055C2 (no)
WO (1) WO1998026779A1 (no)

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WO2000029369A1 (fr) * 1998-11-18 2000-05-25 Asahi Glass Company Ltd. Derives d'acide aminoacrylique et procede de production correspondant
DE19917617A1 (de) * 1999-04-19 2000-10-26 Bayer Ag -(-)Enantiomeres des 2-[2-(1-Chlor-cyclopropyl)-3-(2-chlorphenyl) 2-hydroxy-propyl]-2,4-dihydro-[1,2,4]-triazol-3-thions
AU766014B2 (en) * 1999-07-01 2003-10-09 Wakunaga Pharmaceutical Co., Ltd Quinolinecarboxylic acid derivative or salts thereof
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US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
EP1669354B1 (en) 2003-09-29 2013-03-20 Daiichi Sankyo Company, Limited 8-cyanoquinolonecarboxylic acid derivative
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
PT1828167E (pt) * 2004-06-04 2014-10-08 Debiopharm Int Sa Derivados de acrilamida como agentes antibióticos
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
RU2570731C2 (ru) 2009-07-02 2015-12-10 Алькон Рисерч, Лтд. Композиции, включающие финафлоксации, и способы лечения офтальмологических, ушных или назальных инфекций
RU2449805C1 (ru) 2011-01-27 2012-05-10 Общество С Ограниченной Ответственностью "Гармония" Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования
RS58898B1 (sr) 2012-06-19 2019-08-30 Debiopharm Int Sa Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
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MX2016001912A (es) 2013-08-12 2016-06-02 Novartis Ag Metodos para tratar infecciones oticas luego de la colocacion de un tubo de timpanostomia.
DE102014115951A1 (de) 2014-11-03 2016-05-04 Merlion Pharmaceuticals Pte Ltd. Zusammensetzungen, die Finafloxacin und Tris enthalten
DE102015100068A1 (de) 2015-01-06 2016-07-07 Merlion Pharmaceuticals Pte Ltd. Finafloxacin zur verwendung bei der behandlung von harnwegsinfektionen
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
CN107987074B (zh) * 2017-10-27 2020-12-29 浙江美诺华药物化学有限公司 一种普拉沙星的合成方法
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Also Published As

Publication number Publication date
EP0946176B1 (de) 2002-03-27
HUP0000450A2 (hu) 2000-10-28
ES2175519T3 (es) 2002-11-16
JP2000514825A (ja) 2000-11-07
SK79599A3 (en) 2001-01-18
NZ506162A (en) 2001-06-29
DK0946176T3 (da) 2002-06-10
JP5112395B2 (ja) 2013-01-09
IL130311A0 (en) 2000-06-01
EP0946176A1 (de) 1999-10-06
DE59706808D1 (de) 2002-05-02
IL130311A (en) 2004-01-04
PT946176E (pt) 2002-08-30
CZ216899A3 (cs) 2000-02-16
PL191193B1 (pl) 2006-03-31
RS49684B (sr) 2007-11-15
TR199901754T2 (xx) 1999-09-21
HK1025517A1 (en) 2000-11-17
BG103474A (en) 2000-01-31
CA2274894A1 (en) 1998-06-25
US6432948B1 (en) 2002-08-13
NZ336228A (en) 2000-12-22
US6133260A (en) 2000-10-17
EE9900248A (et) 1999-12-15
CN1245428A (zh) 2000-02-23
EA002477B1 (ru) 2002-06-27
SK283224B6 (sk) 2003-03-04
EE04090B1 (et) 2003-08-15
JP3463939B2 (ja) 2003-11-05
EA199900526A1 (ru) 2000-08-28
JP4463380B2 (ja) 2010-05-19
WO1998026779A1 (de) 1998-06-25
JP2009235106A (ja) 2009-10-15
CZ297364B6 (cs) 2006-11-15
SK283223B6 (sk) 2003-03-04
CZ297363B6 (cs) 2006-11-15
HUP0000450A3 (en) 2001-02-28
UA57055C2 (uk) 2003-06-16
KR100536153B1 (ko) 2005-12-14
BG64615B1 (bg) 2005-09-30
BR9714032A (pt) 2000-05-09
HU226523B1 (en) 2009-03-30
PL333928A1 (en) 2000-01-31
NO325617B1 (no) 2008-06-30
CN100335054C (zh) 2007-09-05
SK14962000A3 (sk) 2003-01-09
KR20000069483A (ko) 2000-11-25
AU717751B2 (en) 2000-03-30
NO992903D0 (no) 1999-06-14
DE19652239A1 (de) 1998-06-18
CA2274894C (en) 2009-04-07
YU27499A (sh) 2002-10-18
JP2000351781A (ja) 2000-12-19
ATE214929T1 (de) 2002-04-15
AU5854198A (en) 1998-07-15

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