NO322826B1 - 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. - Google Patents

1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. Download PDF

Info

Publication number: NO322826B1
Authority: NO; Norway
Prior art keywords: formula; alkyl; radical; hydrogen; aryl
Prior art date: 1997-04-08

Application number

NO19990859A

Other languages

English (en)

Norwegian (no)

Other versions

NO990859D0 (no

NO990859L (no

Inventor

Ludo Edmond Josephine Kennis

Francois Paul Bischoff

Christopher John Love

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-08

Filing date

1999-02-23

Publication date

2006-12-11

1999-02-23 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1999-02-23 Publication of NO990859D0 publication Critical patent/NO990859D0/no

1999-09-30 Publication of NO990859L publication Critical patent/NO990859L/no

2006-12-11 Publication of NO322826B1 publication Critical patent/NO322826B1/no

Links

239000000203 mixture Substances 0.000 title claims description 51
238000002360 preparation method Methods 0.000 title claims description 17
150000001875 compounds Chemical class 0.000 claims description 90
150000003839 salts Chemical class 0.000 claims description 27
229910052739 hydrogen Inorganic materials 0.000 claims description 26
239000001257 hydrogen Substances 0.000 claims description 26
-1 nitro, hydroxy Chemical group 0.000 claims description 25
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 22
239000000460 chlorine Substances 0.000 claims description 20
125000000217 alkyl group Chemical group 0.000 claims description 19
238000000034 method Methods 0.000 claims description 17
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 13
125000003118 aryl group Chemical group 0.000 claims description 13
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
125000001118 alkylidene group Chemical group 0.000 claims description 10
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
125000001475 halogen functional group Chemical group 0.000 claims description 9
238000011282 treatment Methods 0.000 claims description 9
239000004480 active ingredient Substances 0.000 claims description 8
125000003545 alkoxy group Chemical group 0.000 claims description 8
239000002585 base Substances 0.000 claims description 7
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229910052736 halogen Inorganic materials 0.000 claims description 6
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
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239000012458 free base Substances 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
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OGOWMVYFFWEWQT-UHFFFAOYSA-N 1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine Chemical class O1C2=CC=CC=C2C2=C1CCNC2 OGOWMVYFFWEWQT-UHFFFAOYSA-N 0.000 claims description 3
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230000000144 pharmacologic effect Effects 0.000 description 1
238000000053 physical method Methods 0.000 description 1
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239000000047 product Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
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239000008213 purified water Substances 0.000 description 1
NYJWYCAHJRGKMI-UHFFFAOYSA-N pyrido[1,2-a]pyrimidin-4-one Chemical compound C1=CC=CN2C(=O)C=CN=C21 NYJWYCAHJRGKMI-UHFFFAOYSA-N 0.000 description 1
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239000012429 reaction media Substances 0.000 description 1
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229960004889 salicylic acid Drugs 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
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239000003549 soybean oil Substances 0.000 description 1
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239000008223 sterile water Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Obesity (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO19990859A 1997-04-08 1999-02-23 1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse. NO322826B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97201045		1997-04-08
PCT/EP1998/002136 WO1998045297A1 (en)	1997-04-08	1998-04-02	1,2,3,4-TETRAHYDRO-BENZOFURO[3,2-c]PYRIDINE DERIVATIVES__

Publications (3)

Publication Number	Publication Date
NO990859D0 NO990859D0 (no)	1999-02-23
NO990859L NO990859L (no)	1999-09-30
NO322826B1 true NO322826B1 (no)	2006-12-11

Family

ID=8228191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19990859A NO322826B1 (no)	1997-04-08	1999-02-23	1,2,3,4-tetrahydro-benzofuro[3,2-c]pyrinderivater, deres fremstilling, sammensetningen omfattende denne og deres anvendelse.

Country Status (31)

Country	Link
US (1)	US6156757A (xx)
EP (1)	EP1019408B1 (xx)
JP (1)	JP3287577B2 (xx)
KR (1)	KR100315975B1 (xx)
CN (1)	CN1097053C (xx)
AP (1)	AP1138A (xx)
AR (1)	AR012576A1 (xx)
AT (1)	ATE270294T1 (xx)
AU (1)	AU727599B2 (xx)
BG (1)	BG63848B1 (xx)
BR (1)	BR9806263A (xx)
CA (1)	CA2264598C (xx)
CZ (1)	CZ290008B6 (xx)
DE (1)	DE69824872T2 (xx)
EE (1)	EE03691B1 (xx)
ES (1)	ES2224391T3 (xx)
GE (1)	GEP20022823B (xx)
HU (1)	HUP0003624A3 (xx)
ID (1)	ID22131A (xx)
IL (1)	IL128701A0 (xx)
MY (1)	MY120033A (xx)
NO (1)	NO322826B1 (xx)
NZ (1)	NZ334501A (xx)
PL (1)	PL189549B1 (xx)
RU (1)	RU2198175C2 (xx)
SK (1)	SK283621B6 (xx)
TR (1)	TR199900644T2 (xx)
TW (1)	TW589315B (xx)
UA (1)	UA52681C2 (xx)
WO (1)	WO1998045297A1 (xx)
ZA (1)	ZA982969B (xx)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA52681C2 (uk) *	1997-04-08	2003-01-15	Янссен Фармацевтика Н.В.	Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі
KR20010071844A (ko) *	1998-10-06	2001-07-31	디르크 반테	의약으로서의 트리사이클릭 δ3-피페리딘
UA70334C2 (en)	1998-10-06	2004-10-15	Janssen Pharmaceutica N V Jans	BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
AU765751B2 (en)	1998-12-21	2003-09-25	Janssen Pharmaceutica N.V.	Benzisoxazoles and phenones as alpha2-antagonists
CA2451606A1 (en)	2001-07-05	2003-01-16	Pharmacia & Upjohn Company	(hetero) aryl substituted benzofurans as 5-ht ligands
EP1490338B1 (en) *	2002-04-03	2011-08-24	Orion Corporation	Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
BR0315008A (pt) *	2002-10-04	2005-08-09	Prana Biotechnology Ltd	Compostos neurologicamente ativos
CA2562406C (en) *	2004-04-12	2013-03-19	Taisho Pharmaceutical Co., Ltd.	Cyclic amine compound
JP5483880B2 (ja) *	2006-10-23	2014-05-07	武田薬品工業株式会社	イミノピリジン誘導体およびその用途
US8481569B2 (en)	2008-04-23	2013-07-09	Takeda Pharmaceutical Company Limited	Iminopyridine derivatives and use thereof
TW200948784A (en) *	2008-04-23	2009-12-01	Takeda Pharmaceutical	Iminopyridine derivatives and use thereof
US8575186B2 (en) *	2009-10-05	2013-11-05	Albany Molecular Research, Inc.	Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
US9067949B2 (en)	2011-01-19	2015-06-30	Albany Molecular Research, Inc.	Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
GB201704325D0 (en) *	2017-03-17	2017-05-03	Argonaut Therapeutics Ltd	Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2570701B1 (fr) *	1984-09-27	1987-05-22	Synthelabo	Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique
US4686226A (en) *	1985-09-03	1987-08-11	Merck & Co., Inc.	Substituted benzo[b]furo- and benzo[b]thieno quinolizines
EP0339959A3 (en) *	1988-04-27	1991-03-20	Glaxo Group Limited	Lactam derivatives
UA52681C2 (uk) *	1997-04-08	2003-01-15	Янссен Фармацевтика Н.В.	Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі

1998
- 1998-02-04 UA UA99031180A patent/UA52681C2/uk unknown
- 1998-04-02 RU RU99107290/04A patent/RU2198175C2/ru active
- 1998-04-02 NZ NZ334501A patent/NZ334501A/en unknown
- 1998-04-02 EE EEP199900114A patent/EE03691B1/xx not_active IP Right Cessation
- 1998-04-02 ES ES98921458T patent/ES2224391T3/es not_active Expired - Lifetime
- 1998-04-02 AP APAP/P/1999/001650A patent/AP1138A/en active
- 1998-04-02 TR TR1999/00644T patent/TR199900644T2/xx unknown
- 1998-04-02 SK SK287-99A patent/SK283621B6/sk not_active IP Right Cessation
- 1998-04-02 CN CN98801286A patent/CN1097053C/zh not_active Expired - Lifetime
- 1998-04-02 AU AU74307/98A patent/AU727599B2/en not_active Expired
- 1998-04-02 KR KR1019997002086A patent/KR100315975B1/ko not_active IP Right Cessation
- 1998-04-02 HU HU0003624A patent/HUP0003624A3/hu unknown
- 1998-04-02 ID IDW990147D patent/ID22131A/id unknown
- 1998-04-02 PL PL98332382A patent/PL189549B1/pl unknown
- 1998-04-02 AT AT98921458T patent/ATE270294T1/de not_active IP Right Cessation
- 1998-04-02 BR BR9806263-8A patent/BR9806263A/pt not_active Application Discontinuation
- 1998-04-02 WO PCT/EP1998/002136 patent/WO1998045297A1/en active IP Right Grant
- 1998-04-02 IL IL12870198A patent/IL128701A0/xx not_active IP Right Cessation
- 1998-04-02 JP JP54240698A patent/JP3287577B2/ja not_active Expired - Fee Related
- 1998-04-02 US US09/402,593 patent/US6156757A/en not_active Expired - Lifetime
- 1998-04-02 GE GEAP19985020A patent/GEP20022823B/en unknown
- 1998-04-02 DE DE69824872T patent/DE69824872T2/de not_active Expired - Lifetime
- 1998-04-02 CZ CZ1999682A patent/CZ290008B6/cs not_active IP Right Cessation
- 1998-04-02 EP EP98921458A patent/EP1019408B1/en not_active Expired - Lifetime
- 1998-04-02 CA CA002264598A patent/CA2264598C/en not_active Expired - Lifetime
- 1998-04-03 MY MYPI98001502A patent/MY120033A/en unknown
- 1998-04-07 AR ARP980101598A patent/AR012576A1/es active IP Right Grant
- 1998-04-07 ZA ZA9802969A patent/ZA982969B/xx unknown
- 1998-04-07 TW TW087105162A patent/TW589315B/zh not_active IP Right Cessation
1999
- 1999-02-23 NO NO19990859A patent/NO322826B1/no not_active IP Right Cessation
- 1999-02-25 BG BG103213A patent/BG63848B1/bg unknown

Also Published As

Publication number	Publication date
HUP0003624A3 (en)	2002-09-30
AU7430798A (en)	1998-10-30
AR012576A1 (es)	2000-11-08
CZ68299A3 (cs)	2000-08-16
TW589315B (en)	2004-06-01
HUP0003624A2 (hu)	2001-04-28
ATE270294T1 (de)	2004-07-15
JP3287577B2 (ja)	2002-06-04
KR100315975B1 (ko)	2001-12-22
CN1097053C (zh)	2002-12-25
UA52681C2 (uk)	2003-01-15
PL332382A1 (en)	1999-09-13
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