AR012576A1 - Derivados de 1,2,3,4-tetrahidro-benzofuro[3,2-c]piridina, procedimiento para su preparacion, composiciones que los comprenden, procedimiento para preparar dichas composiciones y el uso de dichos derivados para la fabricacion de un medicamento - Google Patents
Derivados de 1,2,3,4-tetrahidro-benzofuro[3,2-c]piridina, procedimiento para su preparacion, composiciones que los comprenden, procedimiento para preparar dichas composiciones y el uso de dichos derivados para la fabricacion de un medicamentoInfo
- Publication number
- AR012576A1 AR012576A1 ARP980101598A ARP980101598A AR012576A1 AR 012576 A1 AR012576 A1 AR 012576A1 AR P980101598 A ARP980101598 A AR P980101598A AR P980101598 A ARP980101598 A AR P980101598A AR 012576 A1 AR012576 A1 AR 012576A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- procedure
- alkyl
- derivatives
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 239000000203 mixture Substances 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 nitro, hydroxy Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 abstract 1
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 abstract 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001145 hydrido group Chemical group *[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Un compuesto de la formula (I), una forma N-oxido, las sales de adicion farmacéuticamente aceptables y sus formas estereoquímicamente isoméricas donde:cada R1 es independientemente hidrogeno, halogeno, alquilo C1-6, nitro, hidroxi o alquiloxi C1- 4; alc es alcanodiilo C1-6; n es 1 o 2; D es 1- o 2-benzimidazolilo, 2(3H)benzoxazolona-3-ilo o un radical de las formulas (a), (b), (c), (d), (e), (f), (g); donde cada X independientemente representa O, So NR12; R12 es hidrogeno, alquilo C1-6,a rilo o arilalquilo de C1-6; R3 es hidrogeno, alquilo C1-6, alquiloxi C1-6, alquitio C1-6, amino o mono- o di(alquilo C1-6)amino, R4, R5, R6, R7, R8, R9, R10, R11 y R12 son cada uno independientemente hidrogeno o alquilo C1-6; R9 eshidrog eno, alquilo o ariloC1-6; o R3 y R4 tomados juntos pueden formar un radical bivalente -R3-R4 de la formula: -CH2CH2-CH2 (a1); -CH2CH2-CH2-CH2 (a2); CH=CH-CH2- (a3); -CH2-CH=CH-(a4) o -CH=CH-CH=CH (a5); donde uno o dos átomos de hidrogeno dedichos radicales (a1) hasta (a5) cada uno independientemente pueden ser reemplazadospor halo, alquilo C1-6, arilalquilo C1-6, trifluorometilo, amino, hidroxi, alquiloxi C1-6 o alquilcarboniloxi C1-10; o cuando se posible, dos átomos dehidrogenogeminal pueden ser reemplazados por alquilideno C1-6 o arilalquilideno C1-6; o -R3-R4- pueden ser: -S-CH2-CH2 (a6); -S-CH2-CH2-CH2-(a7); -S-CH=CH- (a8); -NH-CH2-CH2- (a9); -NH-CH2-CH2-CH2- (a10); -NH-CH=CH- (a11); -NH-CH=N- (a12);-S-CH=N- (a13) o -CH=CH0-O- (a14) donde uno o cuando esposible dos o tres átomos de hidrogeno en dichos radicales (a6) hasta (a14) cada uno independientemente pueden ser reemplazados por alquilo o arilo C1-6; yaril es fenilo o fenilo sustituidoc on halo o alquilo C1-6. Tienen una actividad antagonista de los receptores adrenérgicos alfa2. Además de refiere
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201045 | 1997-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012576A1 true AR012576A1 (es) | 2000-11-08 |
Family
ID=8228191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101598A AR012576A1 (es) | 1997-04-08 | 1998-04-07 | Derivados de 1,2,3,4-tetrahidro-benzofuro[3,2-c]piridina, procedimiento para su preparacion, composiciones que los comprenden, procedimiento para preparar dichas composiciones y el uso de dichos derivados para la fabricacion de un medicamento |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6156757A (es) |
| EP (1) | EP1019408B1 (es) |
| JP (1) | JP3287577B2 (es) |
| KR (1) | KR100315975B1 (es) |
| CN (1) | CN1097053C (es) |
| AP (1) | AP1138A (es) |
| AR (1) | AR012576A1 (es) |
| AT (1) | ATE270294T1 (es) |
| AU (1) | AU727599B2 (es) |
| BG (1) | BG63848B1 (es) |
| BR (1) | BR9806263A (es) |
| CA (1) | CA2264598C (es) |
| CZ (1) | CZ290008B6 (es) |
| DE (1) | DE69824872T2 (es) |
| EE (1) | EE03691B1 (es) |
| ES (1) | ES2224391T3 (es) |
| GE (1) | GEP20022823B (es) |
| HU (1) | HUP0003624A3 (es) |
| ID (1) | ID22131A (es) |
| IL (1) | IL128701A0 (es) |
| MY (1) | MY120033A (es) |
| NO (1) | NO322826B1 (es) |
| NZ (1) | NZ334501A (es) |
| PL (1) | PL189549B1 (es) |
| RU (1) | RU2198175C2 (es) |
| SK (1) | SK283621B6 (es) |
| TR (1) | TR199900644T2 (es) |
| TW (1) | TW589315B (es) |
| UA (1) | UA52681C2 (es) |
| WO (1) | WO1998045297A1 (es) |
| ZA (1) | ZA982969B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA52681C2 (uk) * | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
| UA70334C2 (en) * | 1998-10-06 | 2004-10-15 | Janssen Pharmaceutica N V Jans | BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS |
| CN1131868C (zh) | 1998-10-06 | 2003-12-24 | 詹森药业有限公司 | 作为药物的三环△3－哌啶 |
| ID28967A (id) * | 1998-12-21 | 2001-07-19 | Janssen Pharmaceutica Nv | Benzisoksazol dan fenon sebagai alfa 2-antagonis |
| CA2451606A1 (en) | 2001-07-05 | 2003-01-16 | Pharmacia & Upjohn Company | (hetero) aryl substituted benzofurans as 5-ht ligands |
| CA2480266C (en) * | 2002-04-03 | 2011-07-12 | Orion Corporation | Use of an alpha2-adrenoreceptor antagonist for cns-related diseases |
| MXPA05003607A (es) * | 2002-10-04 | 2005-11-17 | Prana Biotechnology Ltd | Compuestos neurologicamente activos. |
| CN1972938B (zh) | 2004-04-12 | 2010-09-29 | 大正制药株式会社 | 环状胺化合物 |
| EP2077262A4 (en) * | 2006-10-23 | 2011-12-28 | Takeda Pharmaceutical | IMINOPYRIDINE DERIVATIVES AND THEIR USE |
| US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| ES2478823T3 (es) * | 2008-04-23 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Derivados de iminopiridina y uso de los mismos |
| US8575186B2 (en) * | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
| EP2668191A4 (en) | 2011-01-19 | 2014-08-20 | Albany Molecular Res Inc | BENZOFURO- [3,2-C-] PYRIDINES AND RELATED ANALOGS AS SEROTONIN-SUBTYPE-6 (5-HT6) MODULATORS FOR THE TREATMENT OF ADIPOSITAS, METABOLISM SYNDROME, COGNITION AND SCHIZOPHRENIA |
| GB201704325D0 (en) * | 2017-03-17 | 2017-05-03 | Argonaut Therapeutics Ltd | Compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2570701B1 (fr) * | 1984-09-27 | 1987-05-22 | Synthelabo | Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique |
| US4686226A (en) * | 1985-09-03 | 1987-08-11 | Merck & Co., Inc. | Substituted benzo[b]furo- and benzo[b]thieno quinolizines |
| US4985422A (en) * | 1988-04-27 | 1991-01-15 | Glaxo Group Limited | Lactam derivatives |
| UA52681C2 (uk) * | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
-
1998
- 1998-02-04 UA UA99031180A patent/UA52681C2/uk unknown
- 1998-04-02 DE DE69824872T patent/DE69824872T2/de not_active Expired - Lifetime
- 1998-04-02 GE GEAP19985020A patent/GEP20022823B/en unknown
- 1998-04-02 KR KR1019997002086A patent/KR100315975B1/ko not_active IP Right Cessation
- 1998-04-02 PL PL98332382A patent/PL189549B1/pl unknown
- 1998-04-02 WO PCT/EP1998/002136 patent/WO1998045297A1/en active IP Right Grant
- 1998-04-02 EP EP98921458A patent/EP1019408B1/en not_active Expired - Lifetime
- 1998-04-02 BR BR9806263-8A patent/BR9806263A/pt not_active Application Discontinuation
- 1998-04-02 US US09/402,593 patent/US6156757A/en not_active Expired - Lifetime
- 1998-04-02 RU RU99107290/04A patent/RU2198175C2/ru active
- 1998-04-02 ID IDW990147D patent/ID22131A/id unknown
- 1998-04-02 AP APAP/P/1999/001650A patent/AP1138A/en active
- 1998-04-02 EE EEP199900114A patent/EE03691B1/xx not_active IP Right Cessation
- 1998-04-02 HU HU0003624A patent/HUP0003624A3/hu unknown
- 1998-04-02 NZ NZ334501A patent/NZ334501A/en unknown
- 1998-04-02 CN CN98801286A patent/CN1097053C/zh not_active Expired - Lifetime
- 1998-04-02 AT AT98921458T patent/ATE270294T1/de not_active IP Right Cessation
- 1998-04-02 JP JP54240698A patent/JP3287577B2/ja not_active Expired - Fee Related
- 1998-04-02 ES ES98921458T patent/ES2224391T3/es not_active Expired - Lifetime
- 1998-04-02 CZ CZ1999682A patent/CZ290008B6/cs not_active IP Right Cessation
- 1998-04-02 AU AU74307/98A patent/AU727599B2/en not_active Expired
- 1998-04-02 CA CA002264598A patent/CA2264598C/en not_active Expired - Lifetime
- 1998-04-02 IL IL12870198A patent/IL128701A0/xx not_active IP Right Cessation
- 1998-04-02 SK SK287-99A patent/SK283621B6/sk not_active IP Right Cessation
- 1998-04-02 TR TR1999/00644T patent/TR199900644T2/xx unknown
- 1998-04-03 MY MYPI98001502A patent/MY120033A/en unknown
- 1998-04-07 AR ARP980101598A patent/AR012576A1/es active IP Right Grant
- 1998-04-07 ZA ZA9802969A patent/ZA982969B/xx unknown
- 1998-04-07 TW TW087105162A patent/TW589315B/zh not_active IP Right Cessation
-
1999
- 1999-02-23 NO NO19990859A patent/NO322826B1/no not_active IP Right Cessation
- 1999-02-25 BG BG103213A patent/BG63848B1/bg unknown
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