NO313176B1 - Anvendelse av merkaptoacetylamidderivater for fremstilling av et farmasöytisk preparat for behandling av hyperkolesterolemi - Google Patents
Anvendelse av merkaptoacetylamidderivater for fremstilling av et farmasöytisk preparat for behandling av hyperkolesterolemi Download PDFInfo
- Publication number
- NO313176B1 NO313176B1 NO19963989A NO963989A NO313176B1 NO 313176 B1 NO313176 B1 NO 313176B1 NO 19963989 A NO19963989 A NO 19963989A NO 963989 A NO963989 A NO 963989A NO 313176 B1 NO313176 B1 NO 313176B1
- Authority
- NO
- Norway
- Prior art keywords
- hypercholesterolemia
- treatment
- cholesterol
- preparation
- compound
- Prior art date
Links
- 208000035150 Hypercholesterolemia Diseases 0.000 title claims abstract description 22
- 238000011282 treatment Methods 0.000 title claims description 16
- 238000002360 preparation method Methods 0.000 title claims description 11
- GYXHHICIFZSKKZ-UHFFFAOYSA-N 2-sulfanylacetamide Chemical class NC(=O)CS GYXHHICIFZSKKZ-UHFFFAOYSA-N 0.000 title abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 16
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
- -1 1-oxo-2 (S) -acetylthio-3-phenylpropyl Chemical group 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract description 9
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 33
- 208000029078 coronary artery disease Diseases 0.000 description 12
- 235000012000 cholesterol Nutrition 0.000 description 10
- 108010007622 LDL Lipoproteins Proteins 0.000 description 8
- 102000007330 LDL Lipoproteins Human genes 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
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- 229940079593 drug Drugs 0.000 description 6
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- 238000008214 LDL Cholesterol Methods 0.000 description 5
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- 230000000871 hypocholesterolemic effect Effects 0.000 description 4
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- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Artificial Filaments (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/217,781 US5484783A (en) | 1994-03-24 | 1994-03-24 | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
PCT/US1995/002476 WO1995025548A2 (en) | 1994-03-24 | 1995-02-28 | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
NO963989D0 NO963989D0 (no) | 1996-09-23 |
NO963989L NO963989L (no) | 1996-11-22 |
NO313176B1 true NO313176B1 (no) | 2002-08-26 |
Family
ID=22812484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19963989A NO313176B1 (no) | 1994-03-24 | 1996-09-23 | Anvendelse av merkaptoacetylamidderivater for fremstilling av et farmasöytisk preparat for behandling av hyperkolesterolemi |
Country Status (20)
Country | Link |
---|---|
US (1) | US5484783A (es) |
EP (1) | EP0751775B1 (es) |
JP (1) | JPH09510220A (es) |
KR (1) | KR970701550A (es) |
CN (1) | CN1144483A (es) |
AT (1) | ATE217527T1 (es) |
AU (1) | AU705029B2 (es) |
CA (1) | CA2184693C (es) |
DE (1) | DE69526731T2 (es) |
DK (1) | DK0751775T3 (es) |
ES (1) | ES2173180T3 (es) |
FI (1) | FI118414B (es) |
HU (1) | HU226643B1 (es) |
IL (1) | IL113074A (es) |
NO (1) | NO313176B1 (es) |
NZ (1) | NZ282949A (es) |
PT (1) | PT751775E (es) |
TW (1) | TW323954B (es) |
WO (1) | WO1995025548A2 (es) |
ZA (1) | ZA952285B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US5834353A (en) * | 1997-10-20 | 1998-11-10 | Texas Instruments-Acer Incorporated | Method of making deep sub-micron meter MOSFET with a high permitivity gate dielectric |
US6378430B1 (en) | 1999-10-15 | 2002-04-30 | King Press Corporation | Cylinder with plate gripping device |
DE10229180A1 (de) * | 2002-06-28 | 2004-01-29 | Aventis Pharma Deutschland Gmbh | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
DK1670768T3 (da) * | 2003-10-08 | 2009-11-09 | Lilly Co Eli | Forbindelser og fremgangsmåder til at behandle dyslipidæmi |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
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-
1994
- 1994-03-24 US US08/217,781 patent/US5484783A/en not_active Expired - Lifetime
-
1995
- 1995-02-28 WO PCT/US1995/002476 patent/WO1995025548A2/en active IP Right Grant
- 1995-02-28 NZ NZ282949A patent/NZ282949A/en not_active IP Right Cessation
- 1995-02-28 JP JP7523719A patent/JPH09510220A/ja active Pending
- 1995-02-28 KR KR1019960705294A patent/KR970701550A/ko not_active Application Discontinuation
- 1995-02-28 DE DE69526731T patent/DE69526731T2/de not_active Expired - Lifetime
- 1995-02-28 CN CN95192242A patent/CN1144483A/zh active Pending
- 1995-02-28 HU HU9602603A patent/HU226643B1/hu not_active IP Right Cessation
- 1995-02-28 AU AU20914/95A patent/AU705029B2/en not_active Ceased
- 1995-02-28 ES ES95913501T patent/ES2173180T3/es not_active Expired - Lifetime
- 1995-02-28 CA CA002184693A patent/CA2184693C/en not_active Expired - Fee Related
- 1995-02-28 AT AT95913501T patent/ATE217527T1/de active
- 1995-02-28 DK DK95913501T patent/DK0751775T3/da active
- 1995-02-28 PT PT95913501T patent/PT751775E/pt unknown
- 1995-02-28 EP EP95913501A patent/EP0751775B1/en not_active Expired - Lifetime
- 1995-03-20 ZA ZA952285A patent/ZA952285B/xx unknown
- 1995-03-21 TW TW084102716A patent/TW323954B/zh not_active IP Right Cessation
- 1995-03-22 IL IL11307495A patent/IL113074A/xx not_active IP Right Cessation
-
1996
- 1996-09-23 NO NO19963989A patent/NO313176B1/no not_active IP Right Cessation
- 1996-09-23 FI FI963785A patent/FI118414B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0751775A1 (en) | 1997-01-08 |
HUT74886A (en) | 1997-02-28 |
PT751775E (pt) | 2002-10-31 |
NZ282949A (en) | 1997-07-27 |
NO963989D0 (no) | 1996-09-23 |
AU705029B2 (en) | 1999-05-13 |
IL113074A (en) | 2000-07-26 |
WO1995025548A3 (en) | 1995-11-09 |
NO963989L (no) | 1996-11-22 |
US5484783A (en) | 1996-01-16 |
FI963785A (fi) | 1996-09-23 |
CA2184693C (en) | 2001-01-02 |
FI118414B (fi) | 2007-11-15 |
JPH09510220A (ja) | 1997-10-14 |
HU226643B1 (en) | 2009-05-28 |
TW323954B (en) | 1998-01-01 |
ATE217527T1 (de) | 2002-06-15 |
DK0751775T3 (da) | 2002-08-26 |
ES2173180T3 (es) | 2002-10-16 |
HU9602603D0 (en) | 1996-11-28 |
WO1995025548A2 (en) | 1995-09-28 |
CA2184693A1 (en) | 1995-09-28 |
IL113074A0 (en) | 1995-06-29 |
ZA952285B (en) | 1996-01-09 |
AU2091495A (en) | 1995-10-09 |
CN1144483A (zh) | 1997-03-05 |
DE69526731D1 (en) | 2002-06-20 |
FI963785A0 (fi) | 1996-09-23 |
EP0751775B1 (en) | 2002-05-15 |
KR970701550A (ko) | 1997-04-12 |
DE69526731T2 (de) | 2003-02-06 |
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