PT751775E - Derivados de mercaptoacetilamida hipocolesterolemicos, antiateroscleroticos e hipotrigliceridemicos - Google Patents

Derivados de mercaptoacetilamida hipocolesterolemicos, antiateroscleroticos e hipotrigliceridemicos

Info

Publication number
PT751775E
PT751775E PT95913501T PT95913501T PT751775E PT 751775 E PT751775 E PT 751775E PT 95913501 T PT95913501 T PT 95913501T PT 95913501 T PT95913501 T PT 95913501T PT 751775 E PT751775 E PT 751775E
Authority
PT
Portugal
Prior art keywords
derivatives
mercaptoacetilamide
hypotriglyceridemics
hypocolsterolemics
acetyclostic
Prior art date
Application number
PT95913501T
Other languages
English (en)
Inventor
Richard Cyrus Dage
Gary A Flynn
John F French
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of PT751775E publication Critical patent/PT751775E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Artificial Filaments (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT95913501T 1994-03-24 1995-02-28 Derivados de mercaptoacetilamida hipocolesterolemicos, antiateroscleroticos e hipotrigliceridemicos PT751775E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/217,781 US5484783A (en) 1994-03-24 1994-03-24 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives

Publications (1)

Publication Number Publication Date
PT751775E true PT751775E (pt) 2002-10-31

Family

ID=22812484

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95913501T PT751775E (pt) 1994-03-24 1995-02-28 Derivados de mercaptoacetilamida hipocolesterolemicos, antiateroscleroticos e hipotrigliceridemicos

Country Status (20)

Country Link
US (1) US5484783A (pt)
EP (1) EP0751775B1 (pt)
JP (1) JPH09510220A (pt)
KR (1) KR970701550A (pt)
CN (1) CN1144483A (pt)
AT (1) ATE217527T1 (pt)
AU (1) AU705029B2 (pt)
CA (1) CA2184693C (pt)
DE (1) DE69526731T2 (pt)
DK (1) DK0751775T3 (pt)
ES (1) ES2173180T3 (pt)
FI (1) FI118414B (pt)
HU (1) HU226643B1 (pt)
IL (1) IL113074A (pt)
NO (1) NO313176B1 (pt)
NZ (1) NZ282949A (pt)
PT (1) PT751775E (pt)
TW (1) TW323954B (pt)
WO (1) WO1995025548A2 (pt)
ZA (1) ZA952285B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US5834353A (en) * 1997-10-20 1998-11-10 Texas Instruments-Acer Incorporated Method of making deep sub-micron meter MOSFET with a high permitivity gate dielectric
US6378430B1 (en) 1999-10-15 2002-04-30 King Press Corporation Cylinder with plate gripping device
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
DK1670768T3 (da) * 2003-10-08 2009-11-09 Lilly Co Eli Forbindelser og fremgangsmåder til at behandle dyslipidæmi

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
GR861118B (en) * 1985-04-30 1986-08-18 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874107B (pt) * 1986-06-13 1987-12-09
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5061694A (en) * 1989-10-23 1991-10-29 E. R. Squibb & Sons, Inc. Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
WO1991009840A1 (en) * 1989-12-22 1991-07-11 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2057786C (en) * 1990-12-21 2002-06-18 Gary A. Flynn Amino and nitro containing tricyclic compounds useful as inhibitors or ace
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
CA2119019A1 (en) * 1991-09-16 1993-04-01 Harry R. Davis Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Also Published As

Publication number Publication date
EP0751775A1 (en) 1997-01-08
HUT74886A (en) 1997-02-28
NO313176B1 (no) 2002-08-26
NZ282949A (en) 1997-07-27
NO963989D0 (no) 1996-09-23
AU705029B2 (en) 1999-05-13
IL113074A (en) 2000-07-26
WO1995025548A3 (en) 1995-11-09
NO963989L (no) 1996-11-22
US5484783A (en) 1996-01-16
FI963785A (fi) 1996-09-23
CA2184693C (en) 2001-01-02
FI118414B (fi) 2007-11-15
JPH09510220A (ja) 1997-10-14
HU226643B1 (en) 2009-05-28
TW323954B (en) 1998-01-01
ATE217527T1 (de) 2002-06-15
DK0751775T3 (da) 2002-08-26
ES2173180T3 (es) 2002-10-16
HU9602603D0 (en) 1996-11-28
WO1995025548A2 (en) 1995-09-28
CA2184693A1 (en) 1995-09-28
IL113074A0 (en) 1995-06-29
ZA952285B (en) 1996-01-09
AU2091495A (en) 1995-10-09
CN1144483A (zh) 1997-03-05
DE69526731D1 (en) 2002-06-20
FI963785A0 (fi) 1996-09-23
EP0751775B1 (en) 2002-05-15
KR970701550A (ko) 1997-04-12
DE69526731T2 (de) 2003-02-06

Similar Documents

Publication Publication Date Title
PL323825A1 (en) Peptidyloheterocycli compounds useful in treating diorders associated with thrombosin
ES2052871T3 (es) Preparacion de bis (3,5-di-t-butil-4-hidroxifeniltio)metano.
DE69713347D1 (de) Flammbehandlungsverfahren
FI972308A (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
BR9609445A (pt) Derivados de azetidinona no tratamento de aterosclerose
BR9611727A (pt) Derivados de quínolina anti-malária
DE69405919D1 (de) Zusammensetzungen zur Behandlung von Keratinfasern
PT751775E (pt) Derivados de mercaptoacetilamida hipocolesterolemicos, antiateroscleroticos e hipotrigliceridemicos
FR2786100B1 (fr) Nouvelle application therapeutique de la nicergoline
FI963783A0 (fi) Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä aminoasetyylimerkaptojohdannaisia
LV11593A (lv) Dimetikona pielietojums aizcietejumu arstesana
NZ282565A (en) Condensed mercaptoacetylamidedisulphidebenzazepines used in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
BR9710992A (pt) Derivados anticovulsivos úteis no tratamento de psorìase
FR2756754B1 (fr) Composition de traitement de fumees et utilisations
SE9403861D0 (sv) Novel medicinal use
FR2786099B1 (fr) Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
BA95039A (bs) Set za prevenciju i terapiju bolne menstruacije
MX9706424A (es) Uso de la moxonidina para el tratamiento de la aterosclerosis.