FI118414B - Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia - Google Patents

Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia Download PDF

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Publication number
FI118414B
FI118414B FI963785A FI963785A FI118414B FI 118414 B FI118414 B FI 118414B FI 963785 A FI963785 A FI 963785A FI 963785 A FI963785 A FI 963785A FI 118414 B FI118414 B FI 118414B
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FI
Finland
Prior art keywords
compound
hydrogen
formula
alkyl
cholesterol
Prior art date
Application number
FI963785A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963785A (fi
FI963785A0 (fi
Inventor
Richard C Dage
Gary A Flynn
John F French
Original Assignee
Merrell Pharma Inc
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Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI963785A publication Critical patent/FI963785A/fi
Publication of FI963785A0 publication Critical patent/FI963785A0/fi
Application granted granted Critical
Publication of FI118414B publication Critical patent/FI118414B/fi

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Artificial Filaments (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FI963785A 1994-03-24 1996-09-23 Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia FI118414B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/217,781 US5484783A (en) 1994-03-24 1994-03-24 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
US21778194 1994-03-24
PCT/US1995/002476 WO1995025548A2 (en) 1994-03-24 1995-02-28 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide derivatives
US9502476 1995-02-28

Publications (3)

Publication Number Publication Date
FI963785A FI963785A (fi) 1996-09-23
FI963785A0 FI963785A0 (fi) 1996-09-23
FI118414B true FI118414B (fi) 2007-11-15

Family

ID=22812484

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963785A FI118414B (fi) 1994-03-24 1996-09-23 Hypokolesteroleemisia, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamidijohdannaisia

Country Status (20)

Country Link
US (1) US5484783A (es)
EP (1) EP0751775B1 (es)
JP (1) JPH09510220A (es)
KR (1) KR970701550A (es)
CN (1) CN1144483A (es)
AT (1) ATE217527T1 (es)
AU (1) AU705029B2 (es)
CA (1) CA2184693C (es)
DE (1) DE69526731T2 (es)
DK (1) DK0751775T3 (es)
ES (1) ES2173180T3 (es)
FI (1) FI118414B (es)
HU (1) HU226643B1 (es)
IL (1) IL113074A (es)
NO (1) NO313176B1 (es)
NZ (1) NZ282949A (es)
PT (1) PT751775E (es)
TW (1) TW323954B (es)
WO (1) WO1995025548A2 (es)
ZA (1) ZA952285B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US5834353A (en) * 1997-10-20 1998-11-10 Texas Instruments-Acer Incorporated Method of making deep sub-micron meter MOSFET with a high permitivity gate dielectric
US6378430B1 (en) 1999-10-15 2002-04-30 King Press Corporation Cylinder with plate gripping device
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
DK1670768T3 (da) * 2003-10-08 2009-11-09 Lilly Co Eli Forbindelser og fremgangsmåder til at behandle dyslipidæmi

Family Cites Families (28)

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Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
GR861118B (en) * 1985-04-30 1986-08-18 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874107B (es) * 1986-06-13 1987-12-09
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5061694A (en) * 1989-10-23 1991-10-29 E. R. Squibb & Sons, Inc. Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
WO1991009840A1 (en) * 1989-12-22 1991-07-11 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2057786C (en) * 1990-12-21 2002-06-18 Gary A. Flynn Amino and nitro containing tricyclic compounds useful as inhibitors or ace
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
CA2119019A1 (en) * 1991-09-16 1993-04-01 Harry R. Davis Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Also Published As

Publication number Publication date
EP0751775A1 (en) 1997-01-08
HUT74886A (en) 1997-02-28
PT751775E (pt) 2002-10-31
NO313176B1 (no) 2002-08-26
NZ282949A (en) 1997-07-27
NO963989D0 (no) 1996-09-23
AU705029B2 (en) 1999-05-13
IL113074A (en) 2000-07-26
WO1995025548A3 (en) 1995-11-09
NO963989L (no) 1996-11-22
US5484783A (en) 1996-01-16
FI963785A (fi) 1996-09-23
CA2184693C (en) 2001-01-02
JPH09510220A (ja) 1997-10-14
HU226643B1 (en) 2009-05-28
TW323954B (en) 1998-01-01
ATE217527T1 (de) 2002-06-15
DK0751775T3 (da) 2002-08-26
ES2173180T3 (es) 2002-10-16
HU9602603D0 (en) 1996-11-28
WO1995025548A2 (en) 1995-09-28
CA2184693A1 (en) 1995-09-28
IL113074A0 (en) 1995-06-29
ZA952285B (en) 1996-01-09
AU2091495A (en) 1995-10-09
CN1144483A (zh) 1997-03-05
DE69526731D1 (en) 2002-06-20
FI963785A0 (fi) 1996-09-23
EP0751775B1 (en) 2002-05-15
KR970701550A (ko) 1997-04-12
DE69526731T2 (de) 2003-02-06

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