NO309569B1 - Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak - Google Patents

Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak Download PDF

Info

Publication number: NO309569B1
Authority: NO; Norway
Prior art keywords: azatricyclo; dichlorophenyl; decan; chlorophenyl; oxime
Prior art date: 1995-11-02

Application number

NO981609A

Other languages

English (en)

Norwegian (no)

Other versions

NO981609L (no

NO981609D0 (no

Inventor

Joergen Scheel-Krueger

Gunnar M Olsen

Bjarne Hugo Dahl

Leif Helth Jensen

Elsebet Oestergaard Nielsen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-02

Filing date

1998-04-07

Publication date

2001-02-19

1998-04-07 Application filed by Neurosearch As filed Critical Neurosearch As

1998-04-07 Publication of NO981609D0 publication Critical patent/NO981609D0/no

1998-06-26 Publication of NO981609L publication Critical patent/NO981609L/no

2001-02-19 Publication of NO309569B1 publication Critical patent/NO309569B1/no

Links

150000003813 tropane derivatives Chemical class 0.000 title description 5
230000019818 neurotransmitter uptake Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 79
JDPQWHLMBJZURR-UHFFFAOYSA-N decan-5-one Chemical compound CCCCCC(=O)CCCC JDPQWHLMBJZURR-UHFFFAOYSA-N 0.000 claims description 42
DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims description 40
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
239000000203 mixture Substances 0.000 claims description 30
SZMNDOUFZGODBR-UHFFFAOYSA-N decan-5-ol Chemical compound CCCCCC(O)CCCC SZMNDOUFZGODBR-UHFFFAOYSA-N 0.000 claims description 23
208000035475 disorder Diseases 0.000 claims description 22
238000000034 method Methods 0.000 claims description 16
-1 decan-5-one oxime Chemical class 0.000 claims description 15
150000003839 salts Chemical class 0.000 claims description 15
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201000010099 disease Diseases 0.000 claims description 12
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 11
239000001257 hydrogen Substances 0.000 claims description 11
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SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
201000003631 narcolepsy Diseases 0.000 description 1
235000021096 natural sweeteners Nutrition 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
230000007372 neural signaling Effects 0.000 description 1
230000001722 neurochemical effect Effects 0.000 description 1
239000003901 neurotransmitter uptake inhibitor Substances 0.000 description 1
230000012154 norepinephrine uptake Effects 0.000 description 1
229960001158 nortriptyline Drugs 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000006201 parenteral dosage form Substances 0.000 description 1
229960002296 paroxetine Drugs 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000001242 postsynaptic effect Effects 0.000 description 1
206010036596 premature ejaculation Diseases 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
210000000063 presynaptic terminal Anatomy 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
239000003380 propellant Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
229960002601 protriptyline Drugs 0.000 description 1
BWPIARFWQZKAIA-UHFFFAOYSA-N protriptyline Chemical compound C1=CC2=CC=CC=C2C(CCCNC)C2=CC=CC=C21 BWPIARFWQZKAIA-UHFFFAOYSA-N 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000000862 serotonergic effect Effects 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
208000019116 sleep disease Diseases 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
150000003892 tartrate salts Chemical class 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
208000002271 trichotillomania Diseases 0.000 description 1
GGUBFICZYGKNTD-UHFFFAOYSA-N triethyl phosphonoacetate Chemical compound CCOC(=O)CP(=O)(OCC)OCC GGUBFICZYGKNTD-UHFFFAOYSA-N 0.000 description 1
XLRPYZSEQKXZAA-OCAPTIKFSA-N tropane Chemical group C1CC[C@H]2CC[C@@H]1N2C XLRPYZSEQKXZAA-OCAPTIKFSA-N 0.000 description 1
TVXYIDHQHDNHCZ-UHFFFAOYSA-N undecan-1-one Chemical compound CCCCCCCCCC[C]=O TVXYIDHQHDNHCZ-UHFFFAOYSA-N 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000011345 viscous material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Exhaust Gas After Treatment (AREA)

NO981609A 1995-11-02 1998-04-07 Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak NO309569B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK122395		1995-11-02
DK14696		1996-02-13
PCT/EP1996/004793 WO1997016451A1 (en)	1995-11-02	1996-11-04	Fused tropane-derivatives as neurotransmitter reuptake inhibitors

Publications (3)

Publication Number	Publication Date
NO981609D0 NO981609D0 (no)	1998-04-07
NO981609L NO981609L (no)	1998-06-26
NO309569B1 true NO309569B1 (no)	2001-02-19

Family

ID=26063395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO981609A NO309569B1 (no)	1995-11-02	1998-04-07	Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak

Country Status (25)

Country	Link
US (1)	US5998405A (hu)
EP (1)	EP0858461B1 (hu)
JP (1)	JP3157839B2 (hu)
KR (1)	KR100277482B1 (hu)
CN (1)	CN1060775C (hu)
AT (1)	ATE224392T1 (hu)
AU (1)	AU702720B2 (hu)
BR (1)	BR9611300A (hu)
CA (1)	CA2236707C (hu)
CZ (1)	CZ285571B6 (hu)
DE (1)	DE69623799T2 (hu)
DK (1)	DK0858461T3 (hu)
EE (1)	EE03566B1 (hu)
HK (1)	HK1016984A1 (hu)
HU (1)	HUP9802534A3 (hu)
IL (1)	IL123898A (hu)
IS (1)	IS4708A (hu)
NO (1)	NO309569B1 (hu)
NZ (1)	NZ321970A (hu)
PL (1)	PL184843B1 (hu)
RU (1)	RU2162469C2 (hu)
SK (1)	SK282944B6 (hu)
TR (1)	TR199800780T2 (hu)
UA (1)	UA47442C2 (hu)
WO (1)	WO1997016451A1 (hu)

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US6329520B1 (en) *	1990-08-09	2001-12-11	Research Triangle Institute	Cocaine receptor binding ligands
US6706880B2 (en)	1990-08-09	2004-03-16	Research Triangle Institute	Cocaine receptor binding ligands
US6150376A (en) *	1998-08-05	2000-11-21	Georgetown University	Bi- and tri-cyclic aza compounds and their uses
WO2000011001A1 (en)	1998-08-18	2000-03-02	Ucb, S.A.	Muscarinic agonists and antagonists
EP1220854A2 (en) *	1999-09-27	2002-07-10	University Georgetown	Novel tropane analogs
US6479509B1 (en)	2000-05-22	2002-11-12	Research Triangle Institute	Method of promoting smoking cessation
WO2002002559A1 (en) *	2000-07-04	2002-01-10	Neurosearch A/S	Steric isomers of fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
DE60231386D1 (de)	2001-04-09	2009-04-16	Neurosearch As	Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
WO2002094827A1 (en) *	2001-05-23	2002-11-28	Neurosearch A/S	Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW589312B (en)	2001-05-25	2004-06-01	Wyeth Corp	Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
ATE345135T1 (de)	2001-11-30	2006-12-15	Neurosearch As	Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen
MXPA05008315A (es)	2003-02-12	2005-09-20	Neurosearch As	Nuevos derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina.
US7247643B2 (en)	2003-02-12	2007-07-24	Neurosearch A/S	8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20090137625A1 (en)	2005-04-08	2009-05-28	Dan Peters	Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
ATE481386T1 (de)	2005-06-28	2010-10-15	Neurosearch As	Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern
JP2008546826A (ja)	2005-06-28	2008-12-25	ノイロサーチアクティーゼルスカブ	新規な３，９−ジアザ−スピロ［５．５］ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
TW200800980A (en)	2006-02-17	2008-01-01	Neurosearch As	Novel compounds
RU2011143972A (ru)	2009-05-15	2013-06-20	НьюроСёрч А/С	Производные хромен-2-она и их применение в качестве ингибиторов обратного захвата моноаминовых нейромедиаторов
CN102459268A (zh) *	2009-06-19	2012-05-16	雅培制药有限公司	二氮杂高金刚烷衍生物和其使用方法
US20120220604A1 (en)	2009-09-21	2012-08-30	Neurosearch A/S	Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en)	2010-01-29	2011-08-04	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en)	2010-03-25	2011-09-29	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en)	2010-07-02	2012-01-05	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP6052524B1 (ja) *	2015-07-30	2016-12-27	秋夫湯田	持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。
WO2024008808A1 (en)	2022-07-08	2024-01-11	Initiator Pharma A/S	Compound for treatment of female sexual dysfunction
WO2024089247A1 (en)	2022-10-28	2024-05-02	Initiator Pharma A/S	Compound for treatment of pain

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AU672644B2 (en) *	1992-12-23	1996-10-10	Neurosearch A/S	Aryl substituted heterocyclic compounds
JP2899418B2 (ja) *	1994-04-19	1999-06-02	ノイロサーチアクティーゼルスカブ	トロパン誘導体、それらの製造及び用途

1996
- 1996-11-04 AU AU75631/96A patent/AU702720B2/en not_active Ceased
- 1996-11-04 CZ CZ981138A patent/CZ285571B6/cs not_active IP Right Cessation
- 1996-11-04 PL PL96326448A patent/PL184843B1/pl unknown
- 1996-11-04 DE DE69623799T patent/DE69623799T2/de not_active Expired - Lifetime
- 1996-11-04 NZ NZ321970A patent/NZ321970A/en unknown
- 1996-11-04 HU HU9802534A patent/HUP9802534A3/hu unknown
- 1996-11-04 BR BR9611300A patent/BR9611300A/pt not_active Application Discontinuation
- 1996-11-04 DK DK96938064T patent/DK0858461T3/da active
- 1996-11-04 US US09/051,107 patent/US5998405A/en not_active Expired - Lifetime
- 1996-11-04 CN CN96198012A patent/CN1060775C/zh not_active Expired - Fee Related
- 1996-11-04 EP EP96938064A patent/EP0858461B1/en not_active Expired - Lifetime
- 1996-11-04 AT AT96938064T patent/ATE224392T1/de not_active IP Right Cessation
- 1996-11-04 TR TR1998/00780T patent/TR199800780T2/xx unknown
- 1996-11-04 IL IL12389896A patent/IL123898A/en not_active IP Right Cessation
- 1996-11-04 EE EE9800100A patent/EE03566B1/xx not_active IP Right Cessation
- 1996-11-04 RU RU98110007/04A patent/RU2162469C2/ru not_active IP Right Cessation
- 1996-11-04 CA CA002236707A patent/CA2236707C/en not_active Expired - Fee Related
- 1996-11-04 JP JP51708397A patent/JP3157839B2/ja not_active Expired - Fee Related
- 1996-11-04 KR KR1019980702592A patent/KR100277482B1/ko not_active IP Right Cessation
- 1996-11-04 SK SK422-98A patent/SK282944B6/sk unknown
- 1996-11-04 WO PCT/EP1996/004793 patent/WO1997016451A1/en active IP Right Grant
- 1996-11-04 UA UA98041933A patent/UA47442C2/uk unknown
1998
- 1998-03-31 IS IS4708A patent/IS4708A/is unknown
- 1998-04-07 NO NO981609A patent/NO309569B1/no unknown
1999
- 1999-05-24 HK HK99102261A patent/HK1016984A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69623799D1 (de)	2002-10-24
CN1060775C (zh)	2001-01-17
EE03566B1 (et)	2001-12-17
US5998405A (en)	1999-12-07
EP0858461B1 (en)	2002-09-18
KR100277482B1 (ko)	2001-01-15
WO1997016451A1 (en)	1997-05-09
CZ113898A3 (cs)	1998-07-15
MX9803554A (es)	1998-09-30
EE9800100A (et)	1998-10-15
AU7563196A (en)	1997-05-22
BR9611300A (pt)	1999-06-15
CN1201461A (zh)	1998-12-09
UA47442C2 (uk)	2002-07-15
NZ321970A (en)	2000-02-28
JPH11514638A (ja)	1999-12-14
CA2236707A1 (en)	1997-05-09
CZ285571B6 (cs)	1999-09-15
RU2162469C2 (ru)	2001-01-27
ATE224392T1 (de)	2002-10-15
NO981609L (no)	1998-06-26
SK42298A3 (en)	1998-10-07
HUP9802534A2 (hu)	1999-04-28
IL123898A0 (en)	1998-10-30
AU702720B2 (en)	1999-03-04
NO981609D0 (no)	1998-04-07
PL184843B1 (pl)	2002-12-31
CA2236707C (en)	2002-08-06
TR199800780T2 (xx)	1998-07-21
SK282944B6 (sk)	2003-01-09
IS4708A (is)	1998-03-31
DE69623799T2 (de)	2003-01-30
HK1016984A1 (en)	1999-11-12
KR19990064111A (ko)	1999-07-26
JP3157839B2 (ja)	2001-04-16
IL123898A (en)	2001-08-08
EP0858461A1 (en)	1998-08-19
HUP9802534A3 (en)	1999-06-28
PL326448A1 (en)	1998-09-28
DK0858461T3 (da)	2003-01-27

Publication	Publication Date	Title
NO309569B1 (no)	2001-02-19	Fusjonerte tropanderivater som inhiberer for neurotransmitteropptak
NO318731B1 (no)	2005-05-02	Tropanderivater, farmasoytiske preparater som omfatter forbindelsene, anvendelse av forbindelsene til fremstilling av medikamenter og fremgangsmate for fremstilling av forbindelsene.
CA2233541C (en)	2002-04-30	8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
NO325513B1 (no)	2008-05-26	8-azabisyklo(3.2.1)okt-2-en-derivater, farmasoytiske preparater som omfatter forbindelsene, anvendelse av forbindelsene til fremstilling av medikamenter for behandling av en sykdom som gir respons pa aktiviteten til nikotin-ACh-reseptormodulatorer, samt fremgangsmate for fremstilling av forbindelsene.
TW200306830A (en)	2003-12-01	N-[phenyl (piperidin-2-yl) methyl] benzamide derivatives, their preparation and their application in therapy
MXPA98003554A (en)	1998-11-16	Frozen tropan derivatives, its preparation and