HUP9802534A2 - Neurotranszmitter újrafelvételt gátló kondenzált tropánszármazékok és előállításuk, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása - Google Patents
Neurotranszmitter újrafelvételt gátló kondenzált tropánszármazékok és előállításuk, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazásaInfo
- Publication number
- HUP9802534A2 HUP9802534A2 HU9802534A HUP9802534A HUP9802534A2 HU P9802534 A2 HUP9802534 A2 HU P9802534A2 HU 9802534 A HU9802534 A HU 9802534A HU P9802534 A HUP9802534 A HU P9802534A HU P9802534 A2 HUP9802534 A2 HU P9802534A2
- Authority
- HU
- Hungary
- Prior art keywords
- aliphatic
- pipe powder
- pipe
- hydrogen atom
- powder
- Prior art date
Links
- 239000003901 neurotransmitter uptake inhibitor Substances 0.000 title 1
- 150000003813 tropane derivatives Chemical class 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 9
- 125000001931 aliphatic group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Exhaust Gas After Treatment (AREA)
Abstract
A találmány szerinti vegyületek és enantiőmerjeik, ezek elegyei,gyógyászatilag elfőgadható addíciós sói vagy N-őxidjai (I) általánősképletében X és Y együtt =O, =S vagy =N-CN képletű csőpőrtőt vagy =NOR2, =CR3R4,=N-NR7R8, -(CH2)m- vagy -W'-(CH2)pW"- általánős képletű csőpőrtőtjelent, vagy X és Y közül az egyik helyettesítő jelentése hidrőgénatőm, és a másikhelyettesítő jelentése -OR5, -SR5 vagy -NR5R6 általánős képletűcsőpőrt, Z jelentése hidrőgénatőm vagy -COOR9 általánős képletű csőpőrt, amely képletekben R3 és R4 egymástól függetlenül hidrőgén- vagyhalőgénatőm vagy alifás, ciklőalifás vagy arőmás csőpőrt vagy -(CH2)q-COOR2 általánős képletű csőpőrt, R2, R5 és R6 jelentése egymástólfüggetlenül hidrőgénatőm vagy alifás, ciklőalifás vagy arőmás csőpőrtvagy -CO-alkil- vagy -SO2-alkil-csőpőrt, R7 és R8 jelentése egymástólfüggetlenül hidrőgénatőm vagy alifás, ciklőalifás vagy arőmás csőpőrt,és R9 jelentése alifás csőpőrt, W' és W" jelentése egymástólfüggetlenül őxigén- vagy kénatőm, n értéke 2, 3, 4 vagy 5, p értéke 1,2, 3, 4 vagy 5, és q értéke 0, 1, 2, 3 vagy 4, R1 jelentése alifás vagy arőmás csőpőrt, és n értéke 1, 2, 3 vagy 4; ahől az arőmás csőpőrtők helyettesítettek lehetnek. A találmány tárgyköréhez tartőznak tővábbá a fenti vegyületekettartalmaz gyógyászati készítmények, e vegyületek alkalmazásagyógyászati készítmény előállítására, valamint eljárás a vegyületekelőállítására. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK122395 | 1995-11-02 | ||
| DK14696 | 1996-02-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9802534A2 true HUP9802534A2 (hu) | 1999-04-28 |
| HUP9802534A3 HUP9802534A3 (en) | 1999-06-28 |
Family
ID=26063395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802534A HUP9802534A3 (en) | 1995-11-02 | 1996-11-04 | Fused tropane-derivatives as neurotransmitter reuptake inhibitors |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5998405A (hu) |
| EP (1) | EP0858461B1 (hu) |
| JP (1) | JP3157839B2 (hu) |
| KR (1) | KR100277482B1 (hu) |
| CN (1) | CN1060775C (hu) |
| AT (1) | ATE224392T1 (hu) |
| AU (1) | AU702720B2 (hu) |
| BR (1) | BR9611300A (hu) |
| CA (1) | CA2236707C (hu) |
| CZ (1) | CZ285571B6 (hu) |
| DE (1) | DE69623799T2 (hu) |
| DK (1) | DK0858461T3 (hu) |
| EE (1) | EE03566B1 (hu) |
| HK (1) | HK1016984A1 (hu) |
| HU (1) | HUP9802534A3 (hu) |
| IL (1) | IL123898A (hu) |
| IS (1) | IS4708A (hu) |
| NO (1) | NO309569B1 (hu) |
| NZ (1) | NZ321970A (hu) |
| PL (1) | PL184843B1 (hu) |
| RU (1) | RU2162469C2 (hu) |
| SK (1) | SK282944B6 (hu) |
| TR (1) | TR199800780T2 (hu) |
| UA (1) | UA47442C2 (hu) |
| WO (1) | WO1997016451A1 (hu) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329520B1 (en) * | 1990-08-09 | 2001-12-11 | Research Triangle Institute | Cocaine receptor binding ligands |
| US6706880B2 (en) | 1990-08-09 | 2004-03-16 | Research Triangle Institute | Cocaine receptor binding ligands |
| US6150376A (en) * | 1998-08-05 | 2000-11-21 | Georgetown University | Bi- and tri-cyclic aza compounds and their uses |
| ID27544A (id) * | 1998-08-18 | 2001-04-12 | Ucb Sa | Agonis dan antagonis muskarinat |
| US6982271B1 (en) | 1999-09-27 | 2006-01-03 | Georgetown University | Tropane analogs |
| US6479509B1 (en) | 2000-05-22 | 2002-11-12 | Research Triangle Institute | Method of promoting smoking cessation |
| AU2001265820A1 (en) * | 2000-07-04 | 2002-01-14 | Neurosearch A/S | Steric isomers of fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2002080957A1 (en) | 2001-04-09 | 2002-10-17 | Neurosearch A/S | Adenosine a2a receptor antagonists combined with neurotrophic activity compounds in the treatment of parkinson's disease |
| WO2002094827A1 (en) * | 2001-05-23 | 2002-11-28 | Neurosearch A/S | Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| AR035898A1 (es) | 2001-05-25 | 2004-07-21 | Wyeth Corp | Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion |
| DE60216142T2 (de) | 2001-11-30 | 2007-09-06 | Neurosearch A/S | Tropan-Derivate mit einer die Wiederaufnahme von Dopamin hemmenden Aktivität zur Behandlung von ischämischen Erkrankungen |
| WO2004072075A1 (en) | 2003-02-12 | 2004-08-26 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1594868B1 (en) | 2003-02-12 | 2009-11-11 | Neurosearch A/S | 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2008534653A (ja) | 2005-04-08 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
| DE602006016945D1 (de) | 2005-06-28 | 2010-10-28 | Neurosearch As | Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern |
| US7943630B2 (en) | 2005-06-28 | 2011-05-17 | Neurosearch A/S | 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| TW200800980A (en) | 2006-02-17 | 2008-01-01 | Neurosearch As | Novel compounds |
| MX2011011904A (es) | 2009-05-15 | 2011-12-08 | Neurosearch As | Derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina. |
| NZ597511A (en) * | 2009-06-19 | 2014-01-31 | Abbvie Inc | Diazahomoadamantane derivatives and methods of use thereof |
| US20120220604A1 (en) | 2009-09-21 | 2012-08-30 | Neurosearch A/S | Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20130040985A1 (en) | 2010-01-29 | 2013-02-14 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| WO2011117289A1 (en) | 2010-03-25 | 2011-09-29 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors |
| WO2012000881A1 (en) | 2010-07-02 | 2012-01-05 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP6052524B1 (ja) * | 2015-07-30 | 2016-12-27 | 秋夫 湯田 | 持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。 |
| WO2024008808A1 (en) | 2022-07-08 | 2024-01-11 | Initiator Pharma A/S | Compound for treatment of female sexual dysfunction |
| WO2024089247A1 (en) | 2022-10-28 | 2024-05-02 | Initiator Pharma A/S | Compound for treatment of pain |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| NZ284075A (en) * | 1994-04-19 | 1998-01-26 | Neurosearch As | Tropane-2-aldoxine derivatives; neurotransmitter re-uptake inhibiting medicaments |
-
1996
- 1996-11-04 CA CA002236707A patent/CA2236707C/en not_active Expired - Fee Related
- 1996-11-04 TR TR1998/00780T patent/TR199800780T2/xx unknown
- 1996-11-04 HU HU9802534A patent/HUP9802534A3/hu unknown
- 1996-11-04 BR BR9611300A patent/BR9611300A/pt not_active Application Discontinuation
- 1996-11-04 AU AU75631/96A patent/AU702720B2/en not_active Ceased
- 1996-11-04 UA UA98041933A patent/UA47442C2/uk unknown
- 1996-11-04 EE EE9800100A patent/EE03566B1/xx not_active IP Right Cessation
- 1996-11-04 NZ NZ321970A patent/NZ321970A/en unknown
- 1996-11-04 AT AT96938064T patent/ATE224392T1/de not_active IP Right Cessation
- 1996-11-04 DE DE69623799T patent/DE69623799T2/de not_active Expired - Lifetime
- 1996-11-04 SK SK422-98A patent/SK282944B6/sk unknown
- 1996-11-04 CZ CZ981138A patent/CZ285571B6/cs not_active IP Right Cessation
- 1996-11-04 RU RU98110007/04A patent/RU2162469C2/ru not_active IP Right Cessation
- 1996-11-04 WO PCT/EP1996/004793 patent/WO1997016451A1/en active IP Right Grant
- 1996-11-04 EP EP96938064A patent/EP0858461B1/en not_active Expired - Lifetime
- 1996-11-04 PL PL96326448A patent/PL184843B1/pl unknown
- 1996-11-04 CN CN96198012A patent/CN1060775C/zh not_active Expired - Fee Related
- 1996-11-04 US US09/051,107 patent/US5998405A/en not_active Expired - Lifetime
- 1996-11-04 JP JP51708397A patent/JP3157839B2/ja not_active Expired - Fee Related
- 1996-11-04 IL IL12389896A patent/IL123898A/en not_active IP Right Cessation
- 1996-11-04 DK DK96938064T patent/DK0858461T3/da active
- 1996-11-04 KR KR1019980702592A patent/KR100277482B1/ko not_active IP Right Cessation
-
1998
- 1998-03-31 IS IS4708A patent/IS4708A/is unknown
- 1998-04-07 NO NO981609A patent/NO309569B1/no unknown
-
1999
- 1999-05-24 HK HK99102261A patent/HK1016984A1/xx not_active IP Right Cessation
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