DE60231386D1 - Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson - Google Patents
Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinsonInfo
- Publication number
- DE60231386D1 DE60231386D1 DE60231386T DE60231386T DE60231386D1 DE 60231386 D1 DE60231386 D1 DE 60231386D1 DE 60231386 T DE60231386 T DE 60231386T DE 60231386 T DE60231386 T DE 60231386T DE 60231386 D1 DE60231386 D1 DE 60231386D1
- Authority
- DE
- Germany
- Prior art keywords
- adenosine
- treatment
- compounds
- combination
- receptor antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100583 | 2001-04-09 | ||
PCT/DK2002/000228 WO2002080957A1 (en) | 2001-04-09 | 2002-04-04 | Adenosine a2a receptor antagonists combined with neurotrophic activity compounds in the treatment of parkinson's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60231386D1 true DE60231386D1 (de) | 2009-04-16 |
Family
ID=8160425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60231386T Expired - Lifetime DE60231386D1 (de) | 2001-04-09 | 2002-04-04 | Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson |
Country Status (8)
Country | Link |
---|---|
US (1) | US7160899B2 (de) |
EP (1) | EP1379269B1 (de) |
JP (1) | JP2004529916A (de) |
AT (1) | ATE424194T1 (de) |
CA (1) | CA2440196A1 (de) |
DE (1) | DE60231386D1 (de) |
MX (1) | MXPA03009185A (de) |
WO (1) | WO2002080957A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4910500A (en) * | 1999-05-19 | 2000-12-12 | Neurosearch A/S | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
US20040063742A1 (en) * | 2001-02-15 | 2004-04-01 | Dan Peters | Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity |
PT2260850T (pt) | 2002-01-28 | 2018-10-24 | Kyowa Hakko Kogyo Kk | Antagonistas do recetor de a2a para utilização no tratamento de distúrbios de movimento |
CN100415217C (zh) * | 2002-12-19 | 2008-09-03 | 先灵公司 | 腺苷A2a受体拮抗剂的应用 |
TW200507850A (en) * | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
CN101448498B (zh) | 2006-05-16 | 2011-04-27 | 诺普神经科学股份有限公司 | R(+)和s(-)普拉克索的组合物以及使用该组合物的方法 |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US8519148B2 (en) * | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
US20090246134A1 (en) * | 2007-05-30 | 2009-10-01 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
CN102186350A (zh) | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
TWI548411B (zh) * | 2009-04-28 | 2016-09-11 | Kyowa Hakko Kirin Co Ltd | Exercise disorder treatment |
CA2765876A1 (en) * | 2009-06-19 | 2010-12-23 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
EP3838271A1 (de) | 2013-07-12 | 2021-06-23 | Knopp Biosciences LLC | Behandlung eines erhöhten spiegels von eosinophilen und/oder basophilen |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
CA2921378A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
DK3033081T3 (da) | 2013-08-13 | 2021-05-31 | Knopp Biosciences Llc | Sammensætninger og fremgangsmåder til behandling af kronisk urticaria |
WO2018170359A1 (en) * | 2017-03-17 | 2018-09-20 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral nerve disease, disorders, and injuries |
EP4083044A4 (de) * | 2019-12-26 | 2024-03-27 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Verwendung von triazolotriazin-derivaten zur behandlung von krankheiten |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4325254A1 (de) * | 1992-08-10 | 1994-02-17 | Boehringer Ingelheim Kg | Unsymmetrisch substituierte Xanthine |
US5574060A (en) | 1993-08-12 | 1996-11-12 | The United States Of America As Represented By The Department Of Health And Human Services | Selective inhibitors of biogenic amine transporters |
FR2734264B1 (fr) | 1995-05-19 | 1997-08-01 | Lafon Labor | Utilisation de derives d'alpha-aminomethyl-3,4-dichlorobenzyl-thioacetamide pour la fabrication d'un medicament inhibant la recapture de la dopamine et nouveaux composes pour cette utilisation |
IL123583A (en) | 1995-10-13 | 2003-07-31 | Neurosearch As | 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them |
PL184843B1 (pl) | 1995-11-02 | 2002-12-31 | Neurosearch As | Nowe skondensowane pochodne tropanu, sposób ich otrzymywania i zastosowanie oraz kompozycje farmaceutyczne |
AU2388697A (en) * | 1996-04-19 | 1997-11-12 | Neurosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
AU4078397A (en) | 1996-08-16 | 1998-03-06 | Allelix Pharm-Eco, L.L.P. | Slow-onset, long-lasting dopamine reuptake blockers |
US5821386A (en) | 1997-08-15 | 1998-10-13 | Allelix-Pharm-Eco L.P. | Compounds for treating ***e abuse |
US6001330A (en) | 1997-09-12 | 1999-12-14 | Elmaleh; David R. | Diagnostic and therapeutic alkylenediamine compounds and process |
WO1999043678A1 (fr) | 1998-02-24 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Medicaments et prophylaxie contre la maladie de parkinson |
WO1999053909A2 (en) * | 1998-04-23 | 1999-10-28 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for neurotrophic action |
ATE293962T1 (de) | 2000-02-25 | 2005-05-15 | Hoffmann La Roche | Adenosin-rezeptor modulatoren |
AU2001259252A1 (en) * | 2000-04-28 | 2001-11-12 | Curis, Inc. | Neuroprotective compositions |
-
2002
- 2002-04-04 EP EP02759761A patent/EP1379269B1/de not_active Expired - Lifetime
- 2002-04-04 CA CA002440196A patent/CA2440196A1/en not_active Abandoned
- 2002-04-04 US US10/473,809 patent/US7160899B2/en not_active Expired - Fee Related
- 2002-04-04 DE DE60231386T patent/DE60231386D1/de not_active Expired - Lifetime
- 2002-04-04 AT AT02759761T patent/ATE424194T1/de not_active IP Right Cessation
- 2002-04-04 JP JP2002578996A patent/JP2004529916A/ja active Pending
- 2002-04-04 MX MXPA03009185A patent/MXPA03009185A/es active IP Right Grant
- 2002-04-04 WO PCT/DK2002/000228 patent/WO2002080957A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2002080957A1 (en) | 2002-10-17 |
US20040097540A1 (en) | 2004-05-20 |
ATE424194T1 (de) | 2009-03-15 |
EP1379269A1 (de) | 2004-01-14 |
CA2440196A1 (en) | 2002-10-17 |
US7160899B2 (en) | 2007-01-09 |
JP2004529916A (ja) | 2004-09-30 |
MXPA03009185A (es) | 2004-02-17 |
EP1379269B1 (de) | 2009-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |