NO300640B1 - Fremgangsmåte ved fremstilling av nye insulinforbindelser - Google Patents
Fremgangsmåte ved fremstilling av nye insulinforbindelser Download PDFInfo
- Publication number
- NO300640B1 NO300640B1 NO913687A NO913687A NO300640B1 NO 300640 B1 NO300640 B1 NO 300640B1 NO 913687 A NO913687 A NO 913687A NO 913687 A NO913687 A NO 913687A NO 300640 B1 NO300640 B1 NO 300640B1
- Authority
- NO
- Norway
- Prior art keywords
- insulin
- thr
- arg
- represent
- glu
- Prior art date
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- RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 1
- HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- -1 insulin compound Chemical class 0.000 description 1
- 229940127560 insulin pen Drugs 0.000 description 1
- HHMSPIAOYISBOU-IYQBICMXSA-N insulin rabbit Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 HHMSPIAOYISBOU-IYQBICMXSA-N 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 108010066381 preproinsulin Proteins 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 229940070353 protamines Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK134189A DK134189D0 (da) | 1989-03-20 | 1989-03-20 | Insulinforbindelser |
PCT/DK1990/000071 WO1990011299A1 (en) | 1989-03-20 | 1990-03-15 | Novel insulin compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
NO913687D0 NO913687D0 (no) | 1991-09-19 |
NO913687L NO913687L (no) | 1991-11-19 |
NO300640B1 true NO300640B1 (no) | 1997-06-30 |
Family
ID=8103787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO913687A NO300640B1 (no) | 1989-03-20 | 1991-09-19 | Fremgangsmåte ved fremstilling av nye insulinforbindelser |
Country Status (23)
Country | Link |
---|---|
US (1) | US5430016A (da) |
EP (1) | EP0463072B1 (da) |
JP (1) | JPH04503808A (da) |
KR (1) | KR920701250A (da) |
CN (1) | CN1045793A (da) |
AT (1) | ATE116661T1 (da) |
AU (1) | AU637365B2 (da) |
CA (1) | CA2049961A1 (da) |
DD (1) | DD298788A5 (da) |
DE (1) | DE69015811T2 (da) |
DK (2) | DK134189D0 (da) |
ES (1) | ES2068384T3 (da) |
FI (1) | FI914419A0 (da) |
GR (1) | GR1002545B (da) |
HU (1) | HUT58349A (da) |
IE (1) | IE66564B1 (da) |
IL (1) | IL93792A0 (da) |
NO (1) | NO300640B1 (da) |
NZ (1) | NZ232953A (da) |
PT (1) | PT93502B (da) |
WO (1) | WO1990011299A1 (da) |
YU (1) | YU53290A (da) |
ZA (1) | ZA902086B (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US5304473A (en) * | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
TW224471B (da) * | 1991-11-26 | 1994-06-01 | Lilly Co Eli | |
US5948751A (en) * | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
JP2001521006A (ja) | 1997-10-24 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | 不溶性インシュリン組成物 |
US6531448B1 (en) * | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
US7378390B2 (en) * | 1999-12-29 | 2008-05-27 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
KR20040070237A (ko) * | 2001-12-20 | 2004-08-06 | 일라이 릴리 앤드 캄파니 | 연장된 작용 시간을 갖는 인슐린 분자 |
BRPI0409600A (pt) * | 2003-04-29 | 2006-04-18 | Lilly Co Eli | análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina |
US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
WO2008114224A2 (en) * | 2007-03-19 | 2008-09-25 | Insuline Medical Ltd. | Method and device for substance measurement |
WO2008114223A1 (en) * | 2007-03-19 | 2008-09-25 | Insuline Medical Ltd. | Drug delivery device |
US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
EP2231229A1 (en) | 2007-12-18 | 2010-09-29 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
BRPI0907119A2 (pt) * | 2008-01-09 | 2015-07-14 | Sanofi Aventis Deutschland | Derivados de insulina tendo um perfil de ação de tempo extremamente retardado |
KR20100111682A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 glp-1 효능제의 병용물 |
CA2743027C (en) | 2008-11-07 | 2016-04-12 | Insuline Medical Ltd. | Device and method for drug delivery |
ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
HUE037735T2 (hu) | 2009-11-13 | 2018-09-28 | Sanofi Aventis Deutschland | DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény |
BR112013004756B1 (pt) | 2010-08-30 | 2020-04-28 | Sanofi Aventis Deutschland | uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
WO2014178018A1 (en) | 2013-05-02 | 2014-11-06 | Glaxosmithkline Intellectual Property Development Limited | Therapeutic peptides |
JP6970615B2 (ja) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン/リキシセナチド固定比処方 |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
CN106323840A (zh) * | 2016-09-13 | 2017-01-11 | 西南石油大学 | 一种页岩孔隙度测量方法 |
CN109735589B (zh) * | 2019-01-02 | 2020-07-10 | 珠海冀百康生物科技有限公司 | 一种胰岛素DesB30的制备方法 |
CN113773398B (zh) * | 2020-06-10 | 2023-05-23 | 宁波鲲鹏生物科技有限公司 | 一种德谷胰岛素衍生物及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55138393A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | Semisynthesis of insulin |
IE50892B1 (en) * | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
DK147437A (en) * | 1980-02-11 | 1900-01-01 | Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof | |
DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
DK113585D0 (da) * | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
DE3717370A1 (de) * | 1987-05-22 | 1988-12-01 | Hoechst Ag | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
-
1989
- 1989-03-20 DK DK134189A patent/DK134189D0/da not_active IP Right Cessation
-
1990
- 1990-03-15 KR KR1019910701125A patent/KR920701250A/ko active IP Right Grant
- 1990-03-15 ES ES90905190T patent/ES2068384T3/es not_active Expired - Lifetime
- 1990-03-15 DK DK90905190.6T patent/DK0463072T3/da active
- 1990-03-15 DE DE69015811T patent/DE69015811T2/de not_active Expired - Fee Related
- 1990-03-15 EP EP90905190A patent/EP0463072B1/en not_active Expired - Lifetime
- 1990-03-15 HU HU902706A patent/HUT58349A/hu unknown
- 1990-03-15 AU AU53448/90A patent/AU637365B2/en not_active Ceased
- 1990-03-15 AT AT90905190T patent/ATE116661T1/de not_active IP Right Cessation
- 1990-03-15 WO PCT/DK1990/000071 patent/WO1990011299A1/en active IP Right Grant
- 1990-03-15 JP JP2505142A patent/JPH04503808A/ja active Pending
- 1990-03-15 CA CA002049961A patent/CA2049961A1/en not_active Abandoned
- 1990-03-16 NZ NZ232953A patent/NZ232953A/en unknown
- 1990-03-19 PT PT93502A patent/PT93502B/pt not_active IP Right Cessation
- 1990-03-19 US US07/495,798 patent/US5430016A/en not_active Expired - Fee Related
- 1990-03-19 ZA ZA902086A patent/ZA902086B/xx unknown
- 1990-03-19 CN CN90101564A patent/CN1045793A/zh active Pending
- 1990-03-19 YU YU53290A patent/YU53290A/sh unknown
- 1990-03-19 IL IL93792A patent/IL93792A0/xx unknown
- 1990-03-19 DD DD90338860A patent/DD298788A5/de not_active IP Right Cessation
- 1990-03-20 IE IE100490A patent/IE66564B1/en not_active IP Right Cessation
- 1990-03-20 GR GR900100206A patent/GR1002545B/el unknown
-
1991
- 1991-09-19 FI FI914419A patent/FI914419A0/fi unknown
- 1991-09-19 NO NO913687A patent/NO300640B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO913687D0 (no) | 1991-09-19 |
DK0463072T3 (da) | 1995-06-12 |
US5430016A (en) | 1995-07-04 |
PT93502B (pt) | 1996-02-29 |
CA2049961A1 (en) | 1990-09-21 |
DE69015811T2 (de) | 1995-05-11 |
GR900100206A (el) | 1991-07-31 |
FI914419A0 (fi) | 1991-09-19 |
AU637365B2 (en) | 1993-05-27 |
ATE116661T1 (de) | 1995-01-15 |
EP0463072B1 (en) | 1995-01-04 |
YU53290A (sh) | 1992-12-21 |
NO913687L (no) | 1991-11-19 |
AU5344890A (en) | 1990-10-22 |
DD298788A5 (de) | 1992-03-12 |
IL93792A0 (en) | 1990-12-23 |
KR920701250A (ko) | 1992-08-11 |
HUT58349A (en) | 1992-02-28 |
IE901004L (en) | 1990-09-20 |
ZA902086B (en) | 1990-11-28 |
DK134189D0 (da) | 1989-03-20 |
WO1990011299A1 (en) | 1990-10-04 |
ES2068384T3 (es) | 1995-04-16 |
EP0463072A1 (en) | 1992-01-02 |
CN1045793A (zh) | 1990-10-03 |
HU902706D0 (en) | 1991-12-30 |
IE66564B1 (en) | 1996-01-24 |
DE69015811D1 (de) | 1995-02-16 |
GR1002545B (el) | 1997-01-28 |
PT93502A (pt) | 1990-11-07 |
NZ232953A (en) | 1992-10-28 |
JPH04503808A (ja) | 1992-07-09 |
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