GR900100206A - Μέ?οδος παρασκευής νέων συν?έσεων ινσουλίνης. - Google Patents

Μέ?οδος παρασκευής νέων συν?έσεων ινσουλίνης.

Info

Publication number
GR900100206A
GR900100206A GR900100206A GR900100206A GR900100206A GR 900100206 A GR900100206 A GR 900100206A GR 900100206 A GR900100206 A GR 900100206A GR 900100206 A GR900100206 A GR 900100206A GR 900100206 A GR900100206 A GR 900100206A
Authority
GR
Greece
Prior art keywords
xqyμz
uæμ
μuzwðsvuæ
wxwð
qxw
Prior art date
Application number
GR900100206A
Other languages
English (en)
Other versions
GR1002545B (el
Inventor
Per Balschmidt
Benned Finn Hansen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of GR900100206A publication Critical patent/GR900100206A/el
Publication of GR1002545B publication Critical patent/GR1002545B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR900100206A 1989-03-20 1990-03-20 Μεθοδος παρασκευης νεων συνθεσεων ινσουλινης. GR1002545B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK134189A DK134189D0 (da) 1989-03-20 1989-03-20 Insulinforbindelser

Publications (2)

Publication Number Publication Date
GR900100206A true GR900100206A (el) 1991-07-31
GR1002545B GR1002545B (el) 1997-01-28

Family

ID=8103787

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100206A GR1002545B (el) 1989-03-20 1990-03-20 Μεθοδος παρασκευης νεων συνθεσεων ινσουλινης.

Country Status (23)

Country Link
US (1) US5430016A (el)
EP (1) EP0463072B1 (el)
JP (1) JPH04503808A (el)
KR (1) KR920701250A (el)
CN (1) CN1045793A (el)
AT (1) ATE116661T1 (el)
AU (1) AU637365B2 (el)
CA (1) CA2049961A1 (el)
DD (1) DD298788A5 (el)
DE (1) DE69015811T2 (el)
DK (2) DK134189D0 (el)
ES (1) ES2068384T3 (el)
FI (1) FI914419A0 (el)
GR (1) GR1002545B (el)
HU (1) HUT58349A (el)
IE (1) IE66564B1 (el)
IL (1) IL93792A0 (el)
NO (1) NO300640B1 (el)
NZ (1) NZ232953A (el)
PT (1) PT93502B (el)
WO (1) WO1990011299A1 (el)
YU (1) YU53290A (el)
ZA (1) ZA902086B (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
TW224471B (el) * 1991-11-26 1994-06-01 Lilly Co Eli
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
JP2001521006A (ja) 1997-10-24 2001-11-06 イーライ・リリー・アンド・カンパニー 不溶性インシュリン組成物
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US7378390B2 (en) * 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
KR20040070237A (ko) * 2001-12-20 2004-08-06 일라이 릴리 앤드 캄파니 연장된 작용 시간을 갖는 인슐린 분자
BRPI0409600A (pt) * 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2008114224A2 (en) * 2007-03-19 2008-09-25 Insuline Medical Ltd. Method and device for substance measurement
WO2008114223A1 (en) * 2007-03-19 2008-09-25 Insuline Medical Ltd. Drug delivery device
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
EP2231229A1 (en) 2007-12-18 2010-09-29 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
BRPI0907119A2 (pt) * 2008-01-09 2015-07-14 Sanofi Aventis Deutschland Derivados de insulina tendo um perfil de ação de tempo extremamente retardado
KR20100111682A (ko) 2008-01-09 2010-10-15 사노피-아벤티스 도이칠란트 게엠베하 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
KR101820024B1 (ko) 2008-10-17 2018-01-18 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
CA2743027C (en) 2008-11-07 2016-04-12 Insuline Medical Ltd. Device and method for drug delivery
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
HUE037735T2 (hu) 2009-11-13 2018-09-28 Sanofi Aventis Deutschland DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény
BR112013004756B1 (pt) 2010-08-30 2020-04-28 Sanofi Aventis Deutschland uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
WO2014178018A1 (en) 2013-05-02 2014-11-06 Glaxosmithkline Intellectual Property Development Limited Therapeutic peptides
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN106323840A (zh) * 2016-09-13 2017-01-11 西南石油大学 一种页岩孔隙度测量方法
CN109735589B (zh) * 2019-01-02 2020-07-10 珠海冀百康生物科技有限公司 一种胰岛素DesB30的制备方法
CN113773398B (zh) * 2020-06-10 2023-05-23 宁波鲲鹏生物科技有限公司 一种德谷胰岛素衍生物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
EP0195691A1 (en) * 1985-03-22 1986-09-24 Novo Nordisk A/S Process for the preparation of Insulin Precursors and process for the preparation of human insulin
EP0347845A2 (en) * 1988-06-20 1989-12-27 Novo Nordisk A/S Insulin precursors, their preparation, and DNA sequences, expression vehicles and primers and a process for producing human insulin and analogues
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
EP0195691A1 (en) * 1985-03-22 1986-09-24 Novo Nordisk A/S Process for the preparation of Insulin Precursors and process for the preparation of human insulin
EP0347845A2 (en) * 1988-06-20 1989-12-27 Novo Nordisk A/S Insulin precursors, their preparation, and DNA sequences, expression vehicles and primers and a process for producing human insulin and analogues
EP0376156A2 (de) * 1988-12-29 1990-07-04 Hoechst Aktiengesellschaft Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOCH. JOURNAL, vol. 186, 1980, pages 945-952, London, GB; P. R\SEN et al.: "Binding of insulin to bovine liver plasma membrane" *
CLAIMS SEARCHED: ALL *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 83, no. 18, September 1986, pages 6766-6770, Washington, DC, US; L. THIM et al.: "Secretion and processing of insulin precursors in yeast" *
PROTEIN ENGINEERING, vol. 2, no. 2, July 1988, pages 157-166, IRL Press Ltd, Eynsham, Oxford, GB; J. MARKUSSEN et al.: "Soluble, prolonged-acting insulin derivatives. III. Degree of protraction. crystallizability and chemical stability of insulins substituted in positions A21,B13,B23,B27 and B30" *

Also Published As

Publication number Publication date
NO913687D0 (no) 1991-09-19
DK0463072T3 (da) 1995-06-12
US5430016A (en) 1995-07-04
PT93502B (pt) 1996-02-29
CA2049961A1 (en) 1990-09-21
DE69015811T2 (de) 1995-05-11
FI914419A0 (fi) 1991-09-19
AU637365B2 (en) 1993-05-27
ATE116661T1 (de) 1995-01-15
EP0463072B1 (en) 1995-01-04
YU53290A (sh) 1992-12-21
NO913687L (no) 1991-11-19
AU5344890A (en) 1990-10-22
DD298788A5 (de) 1992-03-12
IL93792A0 (en) 1990-12-23
KR920701250A (ko) 1992-08-11
HUT58349A (en) 1992-02-28
IE901004L (en) 1990-09-20
ZA902086B (en) 1990-11-28
DK134189D0 (da) 1989-03-20
WO1990011299A1 (en) 1990-10-04
ES2068384T3 (es) 1995-04-16
EP0463072A1 (en) 1992-01-02
CN1045793A (zh) 1990-10-03
NO300640B1 (no) 1997-06-30
HU902706D0 (en) 1991-12-30
IE66564B1 (en) 1996-01-24
DE69015811D1 (de) 1995-02-16
GR1002545B (el) 1997-01-28
PT93502A (pt) 1990-11-07
NZ232953A (en) 1992-10-28
JPH04503808A (ja) 1992-07-09

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