NO20072116L - Farmasoytiske forbindelser - Google Patents
Farmasoytiske forbindelserInfo
- Publication number
- NO20072116L NO20072116L NO20072116A NO20072116A NO20072116L NO 20072116 L NO20072116 L NO 20072116L NO 20072116 A NO20072116 A NO 20072116A NO 20072116 A NO20072116 A NO 20072116A NO 20072116 L NO20072116 L NO 20072116L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- group
- unsubstituted
- membered saturated
- disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
S a m m e n d r a g Kondenserte pyrimidiner med formel (I): hvori A representerer en tiofen-eller furanring; n er 1 eller 3; R1 er en gruppe med formel: hvori m er 0 eller 1; R30 er H- eller C1-C6 - alkyl; R4 og R5 danner, sammen med N - atomet til hvilket de er bundet, en 5- eller 6- leddet mettet N-inneholdende heterosyklisk gruppe som inkluderer 0 eller 1 ytterligere heteroatomer valgt fra N, S og O, som kan være kondensert til en benzenring og som er usubstituert eller substituert; eller en av R4 og R5 er alkyl og den andre er en 5- eller 6- leddet mettet N-inneholdende cyklisk gruppe som definert over eller en alkylgruppe som er substituert med en 5- eller 6- leddet mettet N-inneholdende heterocyklisk gruppe som definert over; R2 er valgt fra: (a) hvori R6 og R7 danner, sammen med nitrogenatomene til hvilket de er bundet, en morfolin-,tiomorfolin-, piperidin-, piperazin-, oksazepan- eller tiazepangruppe som er usubstituert eller substituert; og (b) hvori Y er en C2-C4 alkylenkjede som inneholder, mellom konstituenter karbonatomer i kjeden og/eller ved en eller begge ender av kjeden 1 eller 2 heteroatomer valgt fra O, N og S, og som er usubstituert eller substituert; og R3 er en indazolgruppe som er usubstituert eller substituert; og det farmasøytisk akseptable salt derav har aktivitet som inhibitorer av PI3K og kan således anvendes for å behandle sykdommer eller lidelser oppstått fra abnormal cellevekst, funksjon eller atferd assosiert med PI3-kinase slik som cancer, immunlidelser, kardiovaskulær sykdom, viralinfeksjon, inflammasjon, metabolisme/endokrine lidelser og nevrologiske forstyrrelser. Fremgangsmåter for å syntetisere forbindelsene er også beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0423653.5A GB0423653D0 (en) | 2004-10-25 | 2004-10-25 | Pharmaceutical compounds |
PCT/GB2005/004129 WO2006046031A1 (en) | 2004-10-25 | 2005-10-25 | Pharmaceutical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20072116L true NO20072116L (no) | 2007-07-24 |
Family
ID=33485146
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072116A NO20072116L (no) | 2004-10-25 | 2007-04-24 | Farmasoytiske forbindelser |
NO20072115A NO20072115L (no) | 2004-10-25 | 2007-04-24 | Farmasoytiske forbindelser |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072115A NO20072115L (no) | 2004-10-25 | 2007-04-24 | Farmasoytiske forbindelser |
Country Status (17)
Country | Link |
---|---|
US (8) | US7776856B2 (no) |
EP (3) | EP1812446B1 (no) |
JP (3) | JP5078016B2 (no) |
KR (3) | KR20070084474A (no) |
CN (2) | CN101087795B (no) |
AU (2) | AU2005298404B2 (no) |
BR (2) | BRPI0517019A (no) |
CA (2) | CA2585089C (no) |
ES (3) | ES2554689T3 (no) |
GB (1) | GB0423653D0 (no) |
IL (2) | IL182614A (no) |
MX (2) | MX2007004868A (no) |
NO (2) | NO20072116L (no) |
NZ (2) | NZ554586A (no) |
RU (2) | RU2422449C2 (no) |
WO (3) | WO2006046035A1 (no) |
ZA (2) | ZA200703311B (no) |
Families Citing this family (140)
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GB0423653D0 (en) | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
CL2007001167A1 (es) * | 2006-04-26 | 2008-01-25 | Genentech Inc | Compuestos derivados de pirimidina condensada, inhibidores de p13-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicionfarmaceutica. |
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CL2007001165A1 (es) | 2006-04-26 | 2008-01-25 | Hoffmann La Roche | 2-(1h-indazol-4-il)-6-(4-metanosulfonil-piperazin-1-ilmetil)-4-morfolin-4-il-tieno[3,2-d]pirimidina; procedimiento de preparacion; composicion farmaceutica; proceso de preparacion de dicha composicion; kit farmaceutico; y uso para tratar enfermedades tales como cancer, desordenes inmunes y enfermedades cardiovasculares. |
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