PE20071009A1 - Compuestos derivados de fenoxipiperidinas como antagonistas de histamina h3 - Google Patents

Compuestos derivados de fenoxipiperidinas como antagonistas de histamina h3

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Publication number
PE20071009A1
PE20071009A1 PE2006001648A PE2006001648A PE20071009A1 PE 20071009 A1 PE20071009 A1 PE 20071009A1 PE 2006001648 A PE2006001648 A PE 2006001648A PE 2006001648 A PE2006001648 A PE 2006001648A PE 20071009 A1 PE20071009 A1 PE 20071009A1
Authority
PE
Peru
Prior art keywords
alkyl
halo
histamine
antagonists
phenoxipiperidines
Prior art date
Application number
PE2006001648A
Other languages
English (en)
Inventor
Mwangi W Mutahi
Robert G Aslanian
Michael Y Berlin
Christopher W Boyce
Lera Ruiz Manuel De
Kevin D Mccormick
Daniel M Solomon
Henry A Vaccaro
Junying Zheng
Purakkattle Biju
Younong Yu
Wei Zhou
Xiaohong Zhu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20071009A1 publication Critical patent/PE20071009A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE a ES 0-4; b ES 0-3; M ES CH; n ES 1-2; p ES 0-2; U y W SON CADA UNO CH; X ES UN ENLACE, ALQUILENO, C(O), ENTRE OTROS; Y ES O, CH2, (CH2)2, C(O), ENTRE OTROS; Z ES UN ENLACE, CH(R9)-(R10-ALQUILENO C1-C5), CH(R9)-CH(R9)-O-, ENTRE OTROS; R1 ES R11-ALQUILO, R11-CICLOALQUILO, R11-ARILO, ENTRE OTROS; R2 ES R13-ALQUILO, R13-ALQUENILO, R13-ARILO, R13-ARILALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, HALO, OH, ALCOXI, ENTRE OTROS; R4 ES H, HALO, ALQUILO, HALOALQUILO, ENTRE OTROS; R9 ES H, ALQUILO, HALOALQUILO; R10 ES 1-3 SUSTITUYENTES SELECCIONADOS DE HALO, -CN, -OH, ALCOXI, ENTRE OTROS; R11 ES 1-4 SUSTITUYENTES SELECCIONADOS DE H, HALO, ALQUILO, ALCOXI, ENTRE OTROS. UN COMPUESTO PREFERIDO ES: 4-[2-(2-PIRIDINA)-3H-IMIDAZO[4,5-b]PIRIDINA-3-IL]-FENOXI-4-IL[N-METIL-(2-AMINOPIRIDIN-4-IL)]PIPERIDINA. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE HISTAMINA H3 Y SON UTILES EN TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, AFECCIONES ALERGICAS, DIABETES, OBESIDAD, TRASTORNO DEL SISTEMA CARDIOVASCULAR Y SISTEMA NERVIOSO CENTRAL
PE2006001648A 2005-12-21 2006-12-19 Compuestos derivados de fenoxipiperidinas como antagonistas de histamina h3 PE20071009A1 (es)

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US75263605P 2005-12-21 2005-12-21

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US (1) US7638531B2 (es)
EP (1) EP1976848A2 (es)
JP (1) JP2009521448A (es)
KR (1) KR20080087833A (es)
CN (1) CN101426777A (es)
AU (1) AU2006331882A1 (es)
CA (1) CA2634250A1 (es)
IL (1) IL192309A0 (es)
MX (1) MX2008008337A (es)
PE (1) PE20071009A1 (es)
TW (1) TW200734337A (es)
WO (1) WO2007075629A2 (es)

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