MX2012000178A - 2-carboxamida-cicloamino-ureas utiles como inhibidores de pi3k. - Google Patents

2-carboxamida-cicloamino-ureas utiles como inhibidores de pi3k.

Info

Publication number
MX2012000178A
MX2012000178A MX2012000178A MX2012000178A MX2012000178A MX 2012000178 A MX2012000178 A MX 2012000178A MX 2012000178 A MX2012000178 A MX 2012000178A MX 2012000178 A MX2012000178 A MX 2012000178A MX 2012000178 A MX2012000178 A MX 2012000178A
Authority
MX
Mexico
Prior art keywords
pi3k inhibitors
ureas useful
carboxamide cycloamino
cycloamino ureas
carboxamide
Prior art date
Application number
MX2012000178A
Other languages
English (en)
Inventor
Marc Gerspacher
Robin Alec Fairhurst
Robert Mah
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2012000178A publication Critical patent/MX2012000178A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/06—Antianaemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención se refiere a los compuestos de la fórmula 1: (ver fórmula (I)) y a las sales de los mismos, en donde los sustituyentes son como se definen en la descripción, a composiciones, y al uso de los compuestos en el tratamiento de enfermedades mitigadas por la inhibición de la cinasa de fosfatidil-inositol-3.
MX2012000178A 2009-07-02 2010-06-30 2-carboxamida-cicloamino-ureas utiles como inhibidores de pi3k. MX2012000178A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27002809P 2009-07-02 2009-07-02
PCT/EP2010/059254 WO2011000855A1 (en) 2009-07-02 2010-06-30 2-carboxamide cycloamino ureas useful as pi3k inhibitors

Publications (1)

Publication Number Publication Date
MX2012000178A true MX2012000178A (es) 2012-02-28

Family

ID=42357253

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000178A MX2012000178A (es) 2009-07-02 2010-06-30 2-carboxamida-cicloamino-ureas utiles como inhibidores de pi3k.

Country Status (15)

Country Link
US (1) US8357707B2 (es)
EP (1) EP2448946B1 (es)
JP (1) JP2012531454A (es)
KR (1) KR20120046723A (es)
CN (1) CN102471351A (es)
AR (1) AR077366A1 (es)
AU (1) AU2010268058A1 (es)
BR (1) BR112012000035A2 (es)
CA (1) CA2766853A1 (es)
EA (1) EA201200087A1 (es)
ES (1) ES2432671T3 (es)
MX (1) MX2012000178A (es)
TW (1) TW201103944A (es)
UY (1) UY32748A (es)
WO (1) WO2011000855A1 (es)

Families Citing this family (8)

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US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
CA2868392A1 (en) 2012-05-23 2013-11-28 Estelle DOUDEMENT Compositions and methods of obtaining and using endoderm and hepatocyte cells
US10064866B2 (en) * 2014-04-08 2018-09-04 Incyte Corporation Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
KR20170084558A (ko) * 2016-01-12 2017-07-20 삼성전자주식회사 전자 장치 및 그의 동작 방법
CN106946669B (zh) * 2017-03-21 2020-09-15 国家电网公司 一种环保绝缘气体联产工艺及工业化生产装置
CN106986757B (zh) * 2017-04-24 2020-11-24 国家电网公司 一种环保绝缘气体生产工艺及工业生产装置
CN107935884B (zh) * 2017-11-30 2020-06-12 北京宇极科技发展有限公司 全氟腈的制备方法
CN108424375B (zh) * 2018-04-20 2020-06-02 北京宇极科技发展有限公司 全氟腈的制备方法

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Also Published As

Publication number Publication date
EA201200087A1 (ru) 2012-07-30
CA2766853A1 (en) 2011-01-06
AR077366A1 (es) 2011-08-24
TW201103944A (en) 2011-02-01
EP2448946B1 (en) 2013-07-24
ES2432671T3 (es) 2013-12-04
WO2011000855A1 (en) 2011-01-06
KR20120046723A (ko) 2012-05-10
US8357707B2 (en) 2013-01-22
BR112012000035A2 (pt) 2018-06-19
UY32748A (es) 2011-01-31
JP2012531454A (ja) 2012-12-10
EP2448946A1 (en) 2012-05-09
US20110003786A1 (en) 2011-01-06
CN102471351A (zh) 2012-05-23
AU2010268058A1 (en) 2012-01-19

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