NO20021811L - Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier - Google Patents

Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier

Info

Publication number
NO20021811L
NO20021811L NO20021811A NO20021811A NO20021811L NO 20021811 L NO20021811 L NO 20021811L NO 20021811 A NO20021811 A NO 20021811A NO 20021811 A NO20021811 A NO 20021811A NO 20021811 L NO20021811 L NO 20021811L
Authority
NO
Norway
Prior art keywords
treatment
oxabispidin
new
compounds useful
cardiac arrhythmias
Prior art date
Application number
NO20021811A
Other languages
English (en)
Other versions
NO20021811D0 (no
NO327977B1 (no
Inventor
Annika Bjoere
Magnus Bjoersne
David Cladingboel
Kurt-Juergen Hoffman
John Pavey
Fritiof Ponten
Gert Strandlund
Peder Svensson
Colin Thomson
Michael Wilstermann
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20021811D0 publication Critical patent/NO20021811D0/no
Publication of NO20021811L publication Critical patent/NO20021811L/no
Publication of NO327977B1 publication Critical patent/NO327977B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Oppfinnelsen tilveiebringer forbindelser med formel (I), hvori, R, R, Rtil R, A, B og G har de betydninger som er angitt i beskrivelsen, idet forbindelsene er nyttige ved profylakse og behandling av arytmier, spesielt atriale og ventrikulære arytmier.
NO20021811A 1999-10-18 2002-04-17 Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger som inkluderer nevnte forbindelser, samt mellomprodukter og fremgangsmater til fremstilling av mellomprodukter NO327977B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (3)

Publication Number Publication Date
NO20021811D0 NO20021811D0 (no) 2002-04-17
NO20021811L true NO20021811L (no) 2002-06-06
NO327977B1 NO327977B1 (no) 2009-11-02

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021811A NO327977B1 (no) 1999-10-18 2002-04-17 Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger som inkluderer nevnte forbindelser, samt mellomprodukter og fremgangsmater til fremstilling av mellomprodukter

Country Status (41)

Country Link
US (6) US6559143B1 (no)
EP (2) EP1559717A3 (no)
JP (3) JP3973906B2 (no)
KR (1) KR100796142B1 (no)
CN (2) CN100379743C (no)
AP (1) AP1536A (no)
AR (2) AR026064A1 (no)
AT (1) ATE292134T1 (no)
AU (1) AU769513B2 (no)
BG (1) BG65785B1 (no)
BR (1) BR0014804A (no)
CA (1) CA2386910A1 (no)
CO (1) CO5271655A1 (no)
CU (1) CU23210A3 (no)
CZ (1) CZ20021328A3 (no)
DE (1) DE60019158T2 (no)
DK (1) DK1235831T3 (no)
EA (1) EA005319B1 (no)
EE (1) EE04854B1 (no)
ES (1) ES2239047T3 (no)
HK (1) HK1049003B (no)
HR (1) HRP20020336B1 (no)
HU (1) HUP0204085A3 (no)
IL (5) IL149108A0 (no)
IS (2) IS2224B (no)
MX (1) MXPA02003848A (no)
MY (1) MY130661A (no)
NO (1) NO327977B1 (no)
NZ (2) NZ518156A (no)
OA (1) OA12067A (no)
PL (1) PL354970A1 (no)
PT (1) PT1235831E (no)
RS (1) RS50760B (no)
SE (1) SE9903759D0 (no)
SI (1) SI1235831T1 (no)
SK (1) SK286723B6 (no)
TR (1) TR200201059T2 (no)
TW (1) TWI283680B (no)
UA (1) UA75052C2 (no)
WO (1) WO2001028992A2 (no)
ZA (1) ZA200202575B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
CN1589272A (zh) * 2001-11-22 2005-03-02 阿斯特拉曾尼卡有限公司 从2－氨甲基－2,3－二氢噁嗪化合物制备2－或－9－氧杂－3 , 7－二氮杂双环(3.3.1)壬烷化合物的方法,其中间体,及制备这些中间体的方法
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
KR20080021114A (ko) * 2005-06-13 2008-03-06 아스트라제네카 아베 심부정맥의 치료를 위한 신규한 옥사비스피딘 화합물
AU2006259938B2 (en) * 2005-06-20 2010-07-01 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
CA2610089A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of n,n´- disubstituted oxabispidines
MX2007016498A (es) * 2005-06-20 2008-03-04 Astrazeneca Ab Proceso para la preparacion de 3,7-dihidroxi-1,5-diazaciclooctanos .
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
JPS6284070A (ja) 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規なグリシジル化合物及びその製造法
JPS6284071A (ja) * 1985-10-07 1987-04-17 Kanegafuchi Chem Ind Co Ltd 新規グリシジル化合物及びその製造方法
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
JP2602745B2 (ja) * 1991-06-26 1997-04-23 花王株式会社 フレキシブルディスク用センターハブのピッキング装置
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
RU2254333C2 (ru) 1999-04-09 2005-06-20 Астразенека Аб Производные адамантана, способ их получения, фармацевтическая композиция на их основе и способы лечения
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
US20030153564A1 (en) 2003-08-14
BG65785B1 (bg) 2009-11-30
JP3973906B2 (ja) 2007-09-12
IS2224B (is) 2007-04-15
US7772229B2 (en) 2010-08-10
SI1235831T1 (no) 2005-08-31
CU23210A3 (es) 2007-06-20
HRP20020336A2 (en) 2004-02-29
SK5062002A3 (en) 2002-11-06
AP2002002471A0 (en) 2002-06-30
CN100379743C (zh) 2008-04-09
NZ531260A (en) 2005-08-26
IL183853A0 (en) 2009-02-11
HUP0204085A3 (en) 2006-01-30
AU769513B2 (en) 2004-01-29
PL354970A1 (en) 2004-03-22
EP1559717A2 (en) 2005-08-03
AR026064A1 (es) 2002-12-26
OA12067A (en) 2006-05-04
IS6346A (is) 2002-04-17
PT1235831E (pt) 2005-06-30
HUP0204085A2 (hu) 2003-04-28
IS8586A (is) 2006-12-27
IL149108A (en) 2009-12-24
EA200200390A1 (ru) 2002-10-31
HRP20020336B1 (en) 2006-02-28
YU29402A (sh) 2004-12-31
ES2239047T3 (es) 2005-09-16
US7164017B2 (en) 2007-01-16
RS50760B (sr) 2010-08-31
MXPA02003848A (es) 2002-10-23
BG106588A (en) 2003-01-31
JP2007204486A (ja) 2007-08-16
KR100796142B1 (ko) 2008-01-21
AR039226A2 (es) 2005-02-09
EP1235831B1 (en) 2005-03-30
WO2001028992A3 (en) 2001-09-13
EE200200203A (et) 2003-06-16
NZ518156A (en) 2004-05-28
DE60019158T2 (de) 2006-02-02
CN101265262A (zh) 2008-09-17
CO5271655A1 (es) 2003-04-30
CZ20021328A3 (cs) 2002-09-11
US20070117799A1 (en) 2007-05-24
US6559143B1 (en) 2003-05-06
HK1049003A1 (en) 2003-04-25
UA75052C2 (en) 2006-03-15
AP1536A (en) 2006-01-09
JP2006342182A (ja) 2006-12-21
MY130661A (en) 2007-07-31
US7351821B2 (en) 2008-04-01
SE9903759D0 (sv) 1999-10-18
ATE292134T1 (de) 2005-04-15
IL183854A0 (en) 2009-02-11
DK1235831T3 (da) 2005-06-27
TWI283680B (en) 2007-07-11
TR200201059T2 (tr) 2002-09-23
US20060166980A1 (en) 2006-07-27
EA005319B1 (ru) 2005-02-24
ZA200202575B (en) 2003-09-23
DE60019158D1 (de) 2005-05-04
EP1559717A3 (en) 2009-04-29
EE04854B1 (et) 2007-06-15
EP1235831A2 (en) 2002-09-04
NO20021811D0 (no) 2002-04-17
CA2386910A1 (en) 2001-04-26
JP2003512352A (ja) 2003-04-02
IL149108A0 (en) 2002-11-10
WO2001028992A2 (en) 2001-04-26
BR0014804A (pt) 2002-06-11
HK1049003B (zh) 2005-09-09
CN1399639A (zh) 2003-02-26
AU1069101A (en) 2001-04-30
KR20020038956A (ko) 2002-05-24
SK286723B6 (sk) 2009-04-06
US20090326221A1 (en) 2009-12-31
NO327977B1 (no) 2009-11-02
IL183852A0 (en) 2009-02-11
US20060166979A1 (en) 2006-07-27

Similar Documents

Publication Publication Date Title
NO20021811L (no) Nye oksabispidinforbindelser som er nyttige i behandlingen av hjertearrytmier
WO2003050261A3 (en) (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase
ATE374026T1 (de) Rho-kinase-inhibitoren für die vorbeugung oder behandlung von interstitieller pneumonie und pulmonaler fibrose
NO20090031L (no) Isoindolinderivater for behandling av arytmi
NO20051036L (no) 3,4-disubstituerte syklobuten-1,2-dioner som CXC-kjemokinreseptorligander
TWI256950B (en) Indanyl-substituted benzenecarboxamides, processes for their preparation, their use as a medicament and pharmaceutical formulations containing them
SE9704709D0 (sv) Pharmaceutically active compounds
CA2348735A1 (en) Heterocyclic potassium channel inhibitors
YU24402A (sh) 2'-supstituisani 1,1'-bifenil-2-karbonamidi, postupak za njihovu proizvodnju, njihova primena kao leka kao i farmaceutski preparati koji sadrže ta jedinjenja
NO991761L (no) Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse
NO20070148L (no) Nye oksabispidinforbindelser og deres anvendelse ved behandling av forstyrrelser i hjerterytmen
SE0100326D0 (sv) New compounds
IL159897A0 (en) Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
MXPA02006249A (es) Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas.
MX2010003393A (es) Composiciones de amida del acido indazol acrilico.
NO20070147L (no) Nye oksabispidinforbindelser og deres anvendelse ved behandling av forstyrrelser i hjerterytmen
BR0108592A (pt) Compostos de piperazina substituìda
SE0003795D0 (sv) Pharmaceutically useful compounds
NO20055097L (no) Krystallinske N-formyl-hydroksylaminforbindelser
HK1085467A1 (en) Substituted heterocyclic compounds
ECSP078025A (es) Nuevos compuestos de oxabispidina para el tratamiento de las arritmias cardíacas
SE0002603D0 (sv) New compounds
MXPA05009763A (es) 2-(butil-1-sulfonilamino)-n-[1 (r)-(6-metoxipiridin-3-il) propil] benzamida, su uso en forma de un farmaco y preparaciones farmaceuticas que contienen a dicho compuesto.
NO20071107L (no) 1,1,2,2-tetra(hetero)aryletaner eller 1,1,2-tri(hetero)aryl-2-heterosyklyletaner som kaliumkanalinhibitorer
TR200103663T2 (tr) Kardiyak aritmaların tedavisinde faydalı yeni bispidin bileşikleri

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees