MX2010003393A - Composiciones de amida del acido indazol acrilico. - Google Patents

Composiciones de amida del acido indazol acrilico.

Info

Publication number
MX2010003393A
MX2010003393A MX2010003393A MX2010003393A MX2010003393A MX 2010003393 A MX2010003393 A MX 2010003393A MX 2010003393 A MX2010003393 A MX 2010003393A MX 2010003393 A MX2010003393 A MX 2010003393A MX 2010003393 A MX2010003393 A MX 2010003393A
Authority
MX
Mexico
Prior art keywords
sup
hydrogen
alkyl
indazole
acrylic acid
Prior art date
Application number
MX2010003393A
Other languages
English (en)
Inventor
Tetsuo Yamaguchi
Hiroyuki Kawanishi
Hideki Ushirogochi
Tatsuyuki Takahashi
Tohru Takebe
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of MX2010003393A publication Critical patent/MX2010003393A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de la f?rmula: (ver f?rmula) en donde el anillo X es benceno o piridina; R1 es alquilo sustituido; R2 es arilo sustituido opcionalmente o un grupo heterociclico sustituido opcionalmente; R3 es hidr?geno o alquilo; R4 es hidr?geno, hal?geno o alquilo; R5 es hidr?geno o alquilo; R6 y R7 son los mismos o diferentes, y cada hidr?geno o hal?geno, o una sal farmac?uticamente aceptable del mismo, que es ?til como un bloqueador efectivo de IKur para prevenir o tratar una arritmia cardiaca tal como la fibrilaci?n atrial.
MX2010003393A 2007-09-28 2008-09-26 Composiciones de amida del acido indazol acrilico. MX2010003393A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007253463 2007-09-28
PCT/JP2008/067393 WO2009041559A1 (ja) 2007-09-28 2008-09-26 インダゾールアクリル酸アミド化合物

Publications (1)

Publication Number Publication Date
MX2010003393A true MX2010003393A (es) 2010-04-09

Family

ID=40511439

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003393A MX2010003393A (es) 2007-09-28 2008-09-26 Composiciones de amida del acido indazol acrilico.

Country Status (12)

Country Link
US (1) US8022059B2 (es)
EP (1) EP2192116A4 (es)
JP (1) JPWO2009041559A1 (es)
KR (1) KR20100046064A (es)
CN (1) CN101874022A (es)
AU (1) AU2008304867B2 (es)
BR (1) BRPI0817742A2 (es)
CA (1) CA2700113A1 (es)
MX (1) MX2010003393A (es)
RU (1) RU2444515C2 (es)
TW (1) TW200922558A (es)
WO (1) WO2009041559A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013216579A (ja) * 2010-07-06 2013-10-24 Mitsubishi Tanabe Pharma Corp 三置換インダゾールアクリル酸アミド誘導体の製造方法
BR112013011188B1 (pt) * 2010-11-05 2022-01-04 Senomyx, Inc Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto
WO2013103004A1 (ja) * 2012-01-05 2013-07-11 田辺三菱製薬株式会社 （２ｅ）－３－（１ｈ－インダゾール－３－イル）－ｎ－（３－メトキシフェニル）－ｎ－［３－（メチルスルホニル）プロピル］ブト－２－エンアミドの結晶形
CN105061410B (zh) * 2015-08-03 2018-04-20 江苏红豆杉药业有限公司 一种阿法替尼及其制备方法和应用
EP3356356B1 (en) 2015-10-01 2021-05-26 Firmenich Incorporated Compounds useful as modulators of trpm8
CN111100070A (zh) * 2018-10-26 2020-05-05 北京师范大学 一种阳离子型n-取代苯胺离子液体及其制备方法
US11883499B2 (en) 2022-02-01 2024-01-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules
US11660348B1 (en) 2022-02-01 2023-05-30 Akos Biosciences, Inc. Cannabinoid conjugate molecules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1045716A (ja) * 1996-07-31 1998-02-17 Yamanouchi Pharmaceut Co Ltd ２，３−ジヘテロアリールアクリロイルグアニジン誘導体
AUPO545297A0 (en) * 1997-03-04 1997-03-27 Fujisawa Pharmaceutical Co., Ltd. Guanidine derivatives
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
TW200307539A (en) * 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
EP1648448A4 (en) * 2003-07-29 2009-04-01 Smithkline Beecham Corp CHEMICAL COMPOUNDS
JP4050730B2 (ja) 2004-07-30 2008-02-20 株式会社東芝 酸化物超電導体およびその製造方法

Also Published As

Publication number Publication date
RU2010116779A (ru) 2011-11-10
RU2444515C2 (ru) 2012-03-10
AU2008304867A1 (en) 2009-04-02
AU2008304867B2 (en) 2011-04-21
US20100256108A1 (en) 2010-10-07
CN101874022A (zh) 2010-10-27
JPWO2009041559A1 (ja) 2011-01-27
EP2192116A4 (en) 2011-11-09
BRPI0817742A2 (pt) 2015-03-31
TW200922558A (en) 2009-06-01
WO2009041559A1 (ja) 2009-04-02
EP2192116A1 (en) 2010-06-02
US8022059B2 (en) 2011-09-20
KR20100046064A (ko) 2010-05-04
CA2700113A1 (en) 2009-04-02

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