EA200200390A1 - Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий - Google Patents

Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий

Info

Publication number
EA200200390A1
EA200200390A1 EA200200390A EA200200390A EA200200390A1 EA 200200390 A1 EA200200390 A1 EA 200200390A1 EA 200200390 A EA200200390 A EA 200200390A EA 200200390 A EA200200390 A EA 200200390A EA 200200390 A1 EA200200390 A1 EA 200200390A1
Authority
EA
Eurasian Patent Office
Prior art keywords
useful
treatment
compounds
oxabispidic
arithmia
Prior art date
Application number
EA200200390A
Other languages
English (en)
Other versions
EA005319B1 (ru
Inventor
Анника Бьёре
Магнус Бьёрсне
Дейвид Клейдингбил
Курт-Йюрген Хоффман
Джон Пейви
Фритьоф Понтен
Ерт Страндлунд
Педер Свенссон
Колин Томсон
Микаэль Вильстерманн
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA200200390A1 publication Critical patent/EA200200390A1/ru
Publication of EA005319B1 publication Critical patent/EA005319B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Предложены соединения формулы (I), где R, R, R, R, радикалы от Rдо R, А, В и G имеют значения, приведенные в описании изобретения, которые полезны при профилактике и при лечении аритмий, в частности, предсердной и желудочковой аритмий.Отчет о международном поиске был опубликован 2001.09.13.
EA200200390A 1999-10-18 2000-10-13 Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий EA005319B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
EA200200390A1 true EA200200390A1 (ru) 2002-10-31
EA005319B1 EA005319B1 (ru) 2005-02-24

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200390A EA005319B1 (ru) 1999-10-18 2000-10-13 Новые оксабиспидиновые соединения, полезные при лечении сердечных аритмий

Country Status (41)

Country Link
US (6) US6559143B1 (ru)
EP (2) EP1559717A3 (ru)
JP (3) JP3973906B2 (ru)
KR (1) KR100796142B1 (ru)
CN (2) CN100379743C (ru)
AP (1) AP1536A (ru)
AR (2) AR026064A1 (ru)
AT (1) ATE292134T1 (ru)
AU (1) AU769513B2 (ru)
BG (1) BG65785B1 (ru)
BR (1) BR0014804A (ru)
CA (1) CA2386910A1 (ru)
CO (1) CO5271655A1 (ru)
CU (1) CU23210A3 (ru)
CZ (1) CZ20021328A3 (ru)
DE (1) DE60019158T2 (ru)
DK (1) DK1235831T3 (ru)
EA (1) EA005319B1 (ru)
EE (1) EE04854B1 (ru)
ES (1) ES2239047T3 (ru)
HK (1) HK1049003B (ru)
HR (1) HRP20020336B1 (ru)
HU (1) HUP0204085A3 (ru)
IL (5) IL149108A0 (ru)
IS (2) IS2224B (ru)
MX (1) MXPA02003848A (ru)
MY (1) MY130661A (ru)
NO (1) NO327977B1 (ru)
NZ (2) NZ518156A (ru)
OA (1) OA12067A (ru)
PL (1) PL354970A1 (ru)
PT (1) PT1235831E (ru)
RS (1) RS50760B (ru)
SE (1) SE9903759D0 (ru)
SI (1) SI1235831T1 (ru)
SK (1) SK286723B6 (ru)
TR (1) TR200201059T2 (ru)
TW (1) TWI283680B (ru)
UA (1) UA75052C2 (ru)
WO (1) WO2001028992A2 (ru)
ZA (1) ZA200202575B (ru)

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SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
CN1589272A (zh) * 2001-11-22 2005-03-02 阿斯特拉曾尼卡有限公司 从2－氨甲基－2,3－二氢噁嗪化合物制备2－或－9－氧杂－3 , 7－二氮杂双环(3.3.1)壬烷化合物的方法,其中间体,及制备这些中间体的方法
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
KR20080021114A (ko) * 2005-06-13 2008-03-06 아스트라제네카 아베 심부정맥의 치료를 위한 신규한 옥사비스피딘 화합물
AU2006259938B2 (en) * 2005-06-20 2010-07-01 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
CA2610089A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of n,n´- disubstituted oxabispidines
MX2007016498A (es) * 2005-06-20 2008-03-04 Astrazeneca Ab Proceso para la preparacion de 3,7-dihidroxi-1,5-diazaciclooctanos .
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation

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SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
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AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
US20030153564A1 (en) 2003-08-14
BG65785B1 (bg) 2009-11-30
JP3973906B2 (ja) 2007-09-12
IS2224B (is) 2007-04-15
US7772229B2 (en) 2010-08-10
SI1235831T1 (ru) 2005-08-31
CU23210A3 (es) 2007-06-20
HRP20020336A2 (en) 2004-02-29
SK5062002A3 (en) 2002-11-06
AP2002002471A0 (en) 2002-06-30
CN100379743C (zh) 2008-04-09
NZ531260A (en) 2005-08-26
IL183853A0 (en) 2009-02-11
HUP0204085A3 (en) 2006-01-30
AU769513B2 (en) 2004-01-29
PL354970A1 (en) 2004-03-22
EP1559717A2 (en) 2005-08-03
AR026064A1 (es) 2002-12-26
OA12067A (en) 2006-05-04
IS6346A (is) 2002-04-17
PT1235831E (pt) 2005-06-30
HUP0204085A2 (hu) 2003-04-28
IS8586A (is) 2006-12-27
IL149108A (en) 2009-12-24
HRP20020336B1 (en) 2006-02-28
YU29402A (sh) 2004-12-31
ES2239047T3 (es) 2005-09-16
US7164017B2 (en) 2007-01-16
RS50760B (sr) 2010-08-31
MXPA02003848A (es) 2002-10-23
BG106588A (en) 2003-01-31
JP2007204486A (ja) 2007-08-16
KR100796142B1 (ko) 2008-01-21
AR039226A2 (es) 2005-02-09
EP1235831B1 (en) 2005-03-30
WO2001028992A3 (en) 2001-09-13
EE200200203A (et) 2003-06-16
NZ518156A (en) 2004-05-28
DE60019158T2 (de) 2006-02-02
CN101265262A (zh) 2008-09-17
CO5271655A1 (es) 2003-04-30
CZ20021328A3 (cs) 2002-09-11
US20070117799A1 (en) 2007-05-24
NO20021811L (no) 2002-06-06
US6559143B1 (en) 2003-05-06
HK1049003A1 (en) 2003-04-25
UA75052C2 (en) 2006-03-15
AP1536A (en) 2006-01-09
JP2006342182A (ja) 2006-12-21
MY130661A (en) 2007-07-31
US7351821B2 (en) 2008-04-01
SE9903759D0 (sv) 1999-10-18
ATE292134T1 (de) 2005-04-15
IL183854A0 (en) 2009-02-11
DK1235831T3 (da) 2005-06-27
TWI283680B (en) 2007-07-11
TR200201059T2 (tr) 2002-09-23
US20060166980A1 (en) 2006-07-27
EA005319B1 (ru) 2005-02-24
ZA200202575B (en) 2003-09-23
DE60019158D1 (de) 2005-05-04
EP1559717A3 (en) 2009-04-29
EE04854B1 (et) 2007-06-15
EP1235831A2 (en) 2002-09-04
NO20021811D0 (no) 2002-04-17
CA2386910A1 (en) 2001-04-26
JP2003512352A (ja) 2003-04-02
IL149108A0 (en) 2002-11-10
WO2001028992A2 (en) 2001-04-26
BR0014804A (pt) 2002-06-11
HK1049003B (zh) 2005-09-09
CN1399639A (zh) 2003-02-26
AU1069101A (en) 2001-04-30
KR20020038956A (ko) 2002-05-24
SK286723B6 (sk) 2009-04-06
US20090326221A1 (en) 2009-12-31
NO327977B1 (no) 2009-11-02
IL183852A0 (en) 2009-02-11
US20060166979A1 (en) 2006-07-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU