MXPA04004026A - Conjugados polimericos de inhibidores de la proteina quinasa c. - Google Patents
Conjugados polimericos de inhibidores de la proteina quinasa c.Info
- Publication number
- MXPA04004026A MXPA04004026A MXPA04004026A MXPA04004026A MXPA04004026A MX PA04004026 A MXPA04004026 A MX PA04004026A MX PA04004026 A MXPA04004026 A MX PA04004026A MX PA04004026 A MXPA04004026 A MX PA04004026A MX PA04004026 A MXPA04004026 A MX PA04004026A
- Authority
- MX
- Mexico
- Prior art keywords
- polymer
- inhibitors
- protein kinase
- pkc inhibitor
- polymer conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invencion proporciona conjugados polimericos de inhibidores de la proteina quinasa C (PKC) que comprenden un polimero tal como poli(etilen glicol) fijado covalentemente a un inhibidor de PKC, tal como una molecula de bisindolilmaleimida. El enlace entre el polimero y el inhibidor de PKC es preferiblemente degradable hidroliticamente. La invencion tambien incluye una composicion farmaceutica que comprende un conjugado polimerico de un inhibidor de PKC y un metodo para tratar cualquier condicion correspondiente a un inhibidor de PKC al administrar un conjugado polimerico de la invencion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34053501P | 2001-10-29 | 2001-10-29 | |
PCT/US2002/034666 WO2003037384A2 (en) | 2001-10-29 | 2002-10-29 | Polymer conjugates of protein kinase c inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04004026A true MXPA04004026A (es) | 2004-07-08 |
Family
ID=23333806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04004026A MXPA04004026A (es) | 2001-10-29 | 2002-10-29 | Conjugados polimericos de inhibidores de la proteina quinasa c. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20030143185A1 (es) |
EP (1) | EP1441772A2 (es) |
JP (1) | JP2005508365A (es) |
KR (1) | KR20050040832A (es) |
AU (1) | AU2002342193B2 (es) |
CA (1) | CA2463580A1 (es) |
MX (1) | MXPA04004026A (es) |
WO (1) | WO2003037384A2 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2939696B1 (en) | 2001-10-18 | 2016-03-09 | Nektar Therapeutics | Polymer conjugates of opioid antagonists |
US20050004038A1 (en) * | 2003-06-27 | 2005-01-06 | Lyon Robert P. | Bivalent inhibitors of Glutathione-S-Transferases |
US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
CN102172405B (zh) | 2003-09-17 | 2014-11-12 | 耐科塔医药公司 | 多支链聚合物的药物前体 |
US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
CA2549730C (en) * | 2003-12-16 | 2012-02-14 | Nektar Therapeutics Al, Corporation | Chemically modified small molecules |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
US7671067B2 (en) | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
AU2007325631B9 (en) | 2006-11-30 | 2014-01-30 | Nektar Therapeutics | Method for preparing a polymer conjugate |
BRPI0807232A2 (pt) | 2007-02-09 | 2014-04-29 | Enzon Pharmaceuticals Inc | Tratamento de cânceres resistentes ou refratários com conjugados poliméricos multi-braços de 7-etil-10-hidroxicamptotecina |
WO2009032286A2 (en) * | 2007-09-06 | 2009-03-12 | Nektar Therapeutics Al, Corporation | Oligomer-calcium channel blocker conjugates |
US20110009446A1 (en) * | 2008-01-11 | 2011-01-13 | Nektar Therapeutics | Oligomer-guanidine class conjugates |
JP5588983B2 (ja) | 2008-08-11 | 2014-09-10 | ウェルズ ファーゴ バンク ナショナル アソシエイション | マルチアームポリマーアルカノエートコンジュゲート |
HUE047352T2 (hu) | 2008-09-23 | 2020-04-28 | Nektar Therapeutics | Eljárás ütemezett beadásra kamptotecin elõgyógyszerekkel (például PEG-ironotekánnal) |
WO2010120387A1 (en) * | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
WO2010120388A1 (en) | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
WO2010120386A1 (en) | 2009-04-17 | 2010-10-21 | Nektar Therapeutics | Oligomer-protein tyrosine kinase inhibitor conjugates |
US9315860B2 (en) | 2009-10-26 | 2016-04-19 | Genovoxx Gmbh | Conjugates of nucleotides and method for the application thereof |
WO2012044243A1 (en) | 2010-09-30 | 2012-04-05 | Astrazeneca Ab | Crystalline naloxol-peg conjugate |
US20140371258A1 (en) | 2010-12-17 | 2014-12-18 | Nektar Therapeutics | Water-Soluble Polymer Conjugates of Topotecan |
JP5899241B2 (ja) | 2010-12-21 | 2016-04-06 | ネクター セラピューティクス | ペメトレキセドベースの化合物のマルチアームポリマープロドラッグコンジュゲート |
US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
WO2012088445A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
CN105037398B (zh) * | 2014-04-16 | 2017-10-24 | 深圳永泽医药股份有限公司 | 一种Bcr‑Abl双倍体抑制剂及其制备方法和用途 |
WO2015158291A1 (zh) * | 2014-04-16 | 2015-10-22 | 成都大学 | 一类Bcr-Abl双倍体抑制剂及其制备方法和用途 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
US6673364B1 (en) * | 1995-06-07 | 2004-01-06 | The University Of British Columbia | Liposome having an exchangeable component |
US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
YU48398A (sh) * | 1996-05-01 | 2000-12-28 | Eli Lily And Company | Inhibitori halo-supstituisane protein kinaze c |
PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
US6284783B1 (en) * | 1999-06-09 | 2001-09-04 | The Uab Research Foundation | Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis |
US6559164B1 (en) * | 1999-10-12 | 2003-05-06 | Hoffmann-La Roche Inc. | Substituted pyrroles suitable for continuous infusion |
US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
MXPA03005140A (es) * | 2000-12-08 | 2004-10-15 | Johnson & Johnson | Compuestos de pirrolina sustituidos con indazolilo como inhibidores de cinasa. |
-
2002
- 2002-10-29 MX MXPA04004026A patent/MXPA04004026A/es not_active Application Discontinuation
- 2002-10-29 CA CA002463580A patent/CA2463580A1/en not_active Abandoned
- 2002-10-29 KR KR1020047006368A patent/KR20050040832A/ko not_active Application Discontinuation
- 2002-10-29 US US10/282,915 patent/US20030143185A1/en not_active Abandoned
- 2002-10-29 WO PCT/US2002/034666 patent/WO2003037384A2/en active IP Right Grant
- 2002-10-29 AU AU2002342193A patent/AU2002342193B2/en not_active Ceased
- 2002-10-29 JP JP2003539724A patent/JP2005508365A/ja active Pending
- 2002-10-29 EP EP02776357A patent/EP1441772A2/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2002342193B2 (en) | 2006-10-26 |
CA2463580A1 (en) | 2003-05-08 |
EP1441772A2 (en) | 2004-08-04 |
US20030143185A1 (en) | 2003-07-31 |
WO2003037384A2 (en) | 2003-05-08 |
WO2003037384A3 (en) | 2003-08-28 |
AU2002342193C1 (en) | 2003-05-12 |
KR20050040832A (ko) | 2005-05-03 |
JP2005508365A (ja) | 2005-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA04004026A (es) | Conjugados polimericos de inhibidores de la proteina quinasa c. | |
WO2003032990A3 (en) | Polymer conjugates of opioid antagonists | |
UA103758C2 (ru) | Конъюгаты олигомеров инсулина, их композиции и применение | |
WO1997029779A3 (en) | EGF-Genistein conjugates for the treatment of cancer | |
WO2004110358A3 (en) | Polymeric conjugates for tissue activated drug delivery | |
BR0208373A (pt) | Inibidores da tirosina cinase | |
RS20050263A (en) | Polymer conjugates with decreased antigenicity,methods of preparation and uses thereof | |
BRPI0412671A (pt) | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima | |
CY1109681T1 (el) | Υποκατεστημενα παραγωγα κιναζολινης ως αναστολεις των κινασων aurora | |
HK1048990A1 (en) | Novel compounds. | |
WO2008076333A8 (en) | Polymer-drug conjugates with tether groups for controlled drug delivery | |
ATE253063T1 (de) | 5-ht1f-agonisten | |
WO2005023294A3 (en) | Polyacetal drug conjugates as release system | |
ATE316083T1 (de) | Adamantanderivate | |
BR0208741A (pt) | Derivados de piperidina | |
PT1017675E (pt) | Derivados da camtotecina altamente lipofilos | |
BR0207978A (pt) | N-but-3enil norbuprenorfina e métodos de uso | |
NO20021367D0 (no) | Indolyl-3-glyoksylsyrederivater som har terapeutisk verdifulle egenskaper | |
UA82983C2 (ru) | Полимерные коньюгаты найбластина и способы их использования | |
WO2002042271A3 (en) | Biphenylcarboxamides useful as lipid lowering agents | |
CA2535210A1 (en) | Novel farnesyl protein transferase inhibitors as antitumor agents | |
SE0003476D0 (sv) | Compounds | |
DE69921486D1 (de) | Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren | |
WO2000078795A3 (en) | Rufomycins and derivatives thereof useful as inhibitors of multi-drug resistance associated protein-1 (mrp-1) | |
WO2005027828A3 (en) | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |