CY1109681T1 - Υποκατεστημενα παραγωγα κιναζολινης ως αναστολεις των κινασων aurora - Google Patents
Υποκατεστημενα παραγωγα κιναζολινης ως αναστολεις των κινασων auroraInfo
- Publication number
- CY1109681T1 CY1109681T1 CY20091101316T CY091101316T CY1109681T1 CY 1109681 T1 CY1109681 T1 CY 1109681T1 CY 20091101316 T CY20091101316 T CY 20091101316T CY 091101316 T CY091101316 T CY 091101316T CY 1109681 T1 CY1109681 T1 CY 1109681T1
- Authority
- CY
- Cyprus
- Prior art keywords
- quinazoline derivatives
- inhibitors
- aurora kinases
- substituted quinazoline
- aurora
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Η εφεύρεση παρέχει παράγωγα κιναζολίνης του τύπου (I): στην παρασκευή ενός φαρμάκου για χρήση στην αναστολή κινάσης Aurora και επίσης νέα παράγωγα κιναζολίνης, πορείες για την παρασκευή τους, φαρμακευτικές συνθέσεις που τα περιέχουν και την χρήση τους σε θεραπεία.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01403357 | 2001-12-24 | ||
EP02788214A EP1463506B1 (en) | 2001-12-24 | 2002-12-20 | Substituted quinazoline derivatives as inhibitors of aurora kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109681T1 true CY1109681T1 (el) | 2014-08-13 |
Family
ID=8183051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091101316T CY1109681T1 (el) | 2001-12-24 | 2009-12-17 | Υποκατεστημενα παραγωγα κιναζολινης ως αναστολεις των κινασων aurora |
Country Status (32)
Country | Link |
---|---|
US (2) | US7402585B2 (el) |
EP (1) | EP1463506B1 (el) |
JP (1) | JP4498741B2 (el) |
KR (1) | KR101029281B1 (el) |
CN (1) | CN100491372C (el) |
AR (1) | AR038052A1 (el) |
AT (1) | ATE446093T1 (el) |
AU (1) | AU2002353196B2 (el) |
BR (1) | BRPI0215312B8 (el) |
CA (1) | CA2471577C (el) |
CY (1) | CY1109681T1 (el) |
DE (1) | DE60234125D1 (el) |
DK (1) | DK1463506T3 (el) |
ES (1) | ES2333702T3 (el) |
HK (1) | HK1076598A1 (el) |
HU (1) | HU229477B1 (el) |
IL (1) | IL162541A0 (el) |
IS (1) | IS2758B (el) |
MX (1) | MXPA04006260A (el) |
MY (1) | MY141739A (el) |
NO (1) | NO328159B1 (el) |
NZ (1) | NZ533440A (el) |
PL (1) | PL211694B1 (el) |
PT (1) | PT1463506E (el) |
RU (1) | RU2323215C2 (el) |
SA (1) | SA03230531B1 (el) |
SI (1) | SI1463506T1 (el) |
TW (1) | TWI335818B (el) |
UA (1) | UA82058C2 (el) |
UY (1) | UY27604A1 (el) |
WO (1) | WO2003055491A1 (el) |
ZA (1) | ZA200404923B (el) |
Families Citing this family (81)
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DE60144284D1 (de) | 2000-11-01 | 2011-05-05 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
PT1463506E (pt) * | 2001-12-24 | 2009-12-10 | Astrazeneca Ab | Derivados de quinazolina substituídos como inibidores de aurora cinases |
EP1521747B1 (en) | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
ATE370958T1 (de) | 2002-12-24 | 2007-09-15 | Astrazeneca Ab | Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung |
ES2301981T3 (es) * | 2003-04-16 | 2008-07-01 | Astrazeneca Ab | Derivados de quinazolina para el tratamiento del cancer. |
DE602004015108D1 (de) * | 2003-06-02 | 2008-08-28 | Astrazeneca Ab | (3-((chinazolin-4-yl)amino)-1h-pyrazol-1-yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs |
TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
AU2003304266A1 (en) * | 2003-07-03 | 2005-01-21 | Cambridge University Technical Services Ltd | Use of aurora kinase inhibitors for reducing the resistance of cancer cells |
CN103664802B (zh) * | 2003-08-14 | 2015-08-05 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
EP1673085B1 (en) | 2003-09-26 | 2011-11-09 | Exelixis, Inc. | C-met modulators and methods of use |
EP1678166B1 (en) * | 2003-10-14 | 2009-07-29 | The Arizona Board of Regents on Behalf of the University of Arizona | Protein kinase inhibitors |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
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DK1746999T3 (da) | 2004-05-06 | 2012-01-23 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amider |
ATE485300T1 (de) * | 2004-07-16 | 2010-11-15 | Sunesis Pharmaceuticals Inc | Als aurora-kinase-inhibitoren nutzbare thienopyrimidine |
US7550598B2 (en) * | 2004-08-18 | 2009-06-23 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
KR20070084172A (ko) | 2004-10-12 | 2007-08-24 | 아스트라제네카 아베 | 퀴나졸린 유도체 |
US7713973B2 (en) * | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2008520713A (ja) | 2004-11-17 | 2008-06-19 | ミイカナ セラピューティクス インコーポレイテッド | キナーゼ阻害剤 |
GB0427917D0 (en) * | 2004-12-21 | 2005-01-26 | Astrazeneca Ab | Chemical compounds |
JP5075624B2 (ja) | 2005-04-28 | 2012-11-21 | 田辺三菱製薬株式会社 | シアノピリジン誘導体及びその医薬としての用途 |
GB0510963D0 (en) * | 2005-05-28 | 2005-07-06 | Astrazeneca Ab | Chemical compounds |
WO2007013964A1 (en) * | 2005-07-22 | 2007-02-01 | Sunesis Pharmaceuticals, Inc. | Pyrazolo pyrimidines useful as aurora kinase inhibitors |
AU2006297120B2 (en) * | 2005-09-30 | 2011-05-19 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GB0601215D0 (en) * | 2006-01-21 | 2006-03-01 | Astrazeneca Ab | Chemical compounds |
US7560551B2 (en) | 2006-01-23 | 2009-07-14 | Amgen Inc. | Aurora kinase modulators and method of use |
EA018128B1 (ru) | 2006-01-23 | 2013-05-30 | Амген Инк. | Модуляторы аурора киназы, способы их получения и их применение |
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GB0609617D0 (en) | 2006-05-16 | 2006-06-21 | Astrazeneca Ab | Process & intermediate |
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CA2683152A1 (en) * | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
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KR101733773B1 (ko) | 2009-01-16 | 2017-05-10 | 엑셀리시스, 인코포레이티드 | N-(4-{〔6,7-비스(메틸옥시)퀴놀린-4-일〕옥시}페닐)-n'-(4-플루오로페닐)사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형 |
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2002
- 2002-12-20 PT PT02788214T patent/PT1463506E/pt unknown
- 2002-12-20 MX MXPA04006260A patent/MXPA04006260A/es active IP Right Grant
- 2002-12-20 HU HU0402454A patent/HU229477B1/hu unknown
- 2002-12-20 EP EP02788214A patent/EP1463506B1/en not_active Expired - Lifetime
- 2002-12-20 RU RU2004122926/04A patent/RU2323215C2/ru active
- 2002-12-20 AU AU2002353196A patent/AU2002353196B2/en not_active Expired
- 2002-12-20 PL PL371253A patent/PL211694B1/pl unknown
- 2002-12-20 KR KR1020047010003A patent/KR101029281B1/ko active IP Right Grant
- 2002-12-20 JP JP2003556068A patent/JP4498741B2/ja not_active Expired - Lifetime
- 2002-12-20 SI SI200230864T patent/SI1463506T1/sl unknown
- 2002-12-20 UA UA20040706026A patent/UA82058C2/uk unknown
- 2002-12-20 ES ES02788214T patent/ES2333702T3/es not_active Expired - Lifetime
- 2002-12-20 US US10/499,684 patent/US7402585B2/en not_active Expired - Lifetime
- 2002-12-20 CA CA2471577A patent/CA2471577C/en not_active Expired - Lifetime
- 2002-12-20 WO PCT/GB2002/005845 patent/WO2003055491A1/en active Application Filing
- 2002-12-20 DE DE60234125T patent/DE60234125D1/de not_active Expired - Lifetime
- 2002-12-20 NZ NZ533440A patent/NZ533440A/en not_active IP Right Cessation
- 2002-12-20 BR BRPI0215312A patent/BRPI0215312B8/pt not_active IP Right Cessation
- 2002-12-20 AT AT02788214T patent/ATE446093T1/de active
- 2002-12-20 DK DK02788214T patent/DK1463506T3/da active
- 2002-12-20 IL IL16254102A patent/IL162541A0/xx unknown
- 2002-12-20 CN CNB028283058A patent/CN100491372C/zh not_active Expired - Lifetime
- 2002-12-23 MY MYPI20024859A patent/MY141739A/en unknown
- 2002-12-23 AR ARP020105081A patent/AR038052A1/es active IP Right Grant
- 2002-12-24 TW TW091137139A patent/TWI335818B/zh not_active IP Right Cessation
- 2002-12-24 UY UY27604A patent/UY27604A1/es not_active Application Discontinuation
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2003
- 2003-01-28 SA SA03230531A patent/SA03230531B1/ar unknown
-
2004
- 2004-06-21 IS IS7328A patent/IS2758B/is unknown
- 2004-06-22 ZA ZA2004/04923A patent/ZA200404923B/en unknown
- 2004-07-23 NO NO20043158A patent/NO328159B1/no not_active IP Right Cessation
-
2005
- 2005-09-28 HK HK05108559.1A patent/HK1076598A1/xx not_active IP Right Cessation
-
2008
- 2008-05-28 US US12/128,479 patent/US20090215770A1/en not_active Abandoned
-
2009
- 2009-12-17 CY CY20091101316T patent/CY1109681T1/el unknown
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