YU48398A - Inhibitori halo-supstituisane protein kinaze c - Google Patents

Inhibitori halo-supstituisane protein kinaze c

Info

Publication number
YU48398A
YU48398A YU48398A YU48398A YU48398A YU 48398 A YU48398 A YU 48398A YU 48398 A YU48398 A YU 48398A YU 48398 A YU48398 A YU 48398A YU 48398 A YU48398 A YU 48398A
Authority
YU
Yugoslavia
Prior art keywords
protein kinase
halo
supstituted
inhibitors
compounds
Prior art date
Application number
YU48398A
Other languages
English (en)
Inventor
R. Michael Jirousek
G. Peter Goekjian
Original Assignee
Eli Lily And Company
Mississippi State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lily And Company, Mississippi State University filed Critical Eli Lily And Company
Publication of YU48398A publication Critical patent/YU48398A/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ovaj pronalazak ima za cilj da inovira halo-supstituisani bis-indolmalimid jedinjenja formule: Pronalazak daje postupak dobijanja izloženih jedinjenja i spravljanje farmaceutskih formulacija za upotrebu u inhibiciji Protein Kinaze C kod sisara.
YU48398A 1996-05-01 1997-04-30 Inhibitori halo-supstituisane protein kinaze c YU48398A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1638296P 1996-05-01 1996-05-01

Publications (1)

Publication Number Publication Date
YU48398A true YU48398A (sh) 2000-12-28

Family

ID=21776838

Family Applications (1)

Application Number Title Priority Date Filing Date
YU48398A YU48398A (sh) 1996-05-01 1997-04-30 Inhibitori halo-supstituisane protein kinaze c

Country Status (21)

Country Link
US (1) US5936084A (sh)
EP (1) EP0805158B1 (sh)
JP (1) JP3235840B2 (sh)
KR (1) KR20000065137A (sh)
AT (1) ATE212026T1 (sh)
AU (1) AU703395B2 (sh)
BR (1) BR9709301A (sh)
CA (1) CA2252701C (sh)
CZ (1) CZ347098A3 (sh)
DE (1) DE69709568T2 (sh)
DK (1) DK0805158T3 (sh)
EA (1) EA001450B1 (sh)
ES (1) ES2170918T3 (sh)
IL (1) IL126762A0 (sh)
NO (1) NO310416B1 (sh)
NZ (1) NZ332658A (sh)
PL (1) PL329681A1 (sh)
PT (1) PT805158E (sh)
TR (1) TR199802193T2 (sh)
WO (1) WO1997041127A1 (sh)
YU (1) YU48398A (sh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127401A (en) 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US7425537B2 (en) * 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
ES2245994T3 (es) * 2000-12-08 2006-02-01 Ortho-Mcneil Pharmaceutical, Inc. Compuestos macro-heterociclicos utilizados como inhibidores de quinasa.
WO2003037384A2 (en) * 2001-10-29 2003-05-08 Nektar Therapeutics Al, Corporation Polymer conjugates of protein kinase c inhibitors
WO2003099284A1 (en) 2002-05-22 2003-12-04 Amgen Inc. Amino-pyridine, -pyridine and pyridazine derivatives for use as vanilloid receptor ligands for the treatment of pain
RS20050161A (en) 2002-08-08 2007-09-21 Amgen Inc., Vanilloid receptor ligands and their use in treatments
DE10244453A1 (de) * 2002-09-24 2004-04-01 Phenomiques Gmbh Hemmung der Proteinkinase C-alpha zur Behandlung von Krankheiten
US7245117B1 (en) * 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
WO2005077938A1 (en) * 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
AU2005285045B2 (en) 2004-09-14 2011-10-13 Gilead Pharmasset Llc Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
WO2006089311A1 (en) 2005-02-15 2006-08-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
US8158586B2 (en) * 2005-04-11 2012-04-17 Pharmagap Inc. Inhibitors of protein kinases and uses thereof
WO2006113769A1 (en) * 2005-04-15 2006-10-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2010049947A2 (en) * 2008-10-28 2010-05-06 Accrete Pharmaceutical Private Limited Preparation of gemcitabine and intermediates thereof
CA2764653C (en) * 2009-06-10 2018-01-02 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compounds
ES2769550T3 (es) 2010-08-20 2020-06-26 Chugai Pharmaceutical Co Ltd Composición que comprende un compuesto tetracíclico
SG10201704588XA (en) 2012-09-25 2017-07-28 Chugai Pharmaceutical Co Ltd Ret inhibitor
TWI771839B (zh) 2014-04-25 2022-07-21 日商中外製藥股份有限公司 以高用量含有4環性化合物的製劑
CA2946268A1 (en) 2014-04-25 2015-10-29 Chugai Seiyaku Kabushiki Kaisha Crystal of tetracyclic compound
TWI803187B (zh) 2014-08-08 2023-05-21 日商中外製藥股份有限公司 包含4環性化合物的非晶質體之固體分散體及製劑
WO2016114375A1 (ja) 2015-01-16 2016-07-21 中外製薬株式会社 併用医薬
WO2019000224A1 (zh) * 2017-06-27 2019-01-03 中国海洋大学 双吲哚马来酰亚胺衍生物及其制备方法和用途
SG11202100983XA (en) 2018-09-04 2021-03-30 Chugai Pharmaceutical Co Ltd Method of producing tetracyclic compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5589472A (en) * 1992-09-25 1996-12-31 Vice; Susan F. Diindolo compounds and pharmaceutical compositions containing them
JP3581731B2 (ja) * 1993-12-07 2004-10-27 イーライ・リリー・アンド・カンパニー プロテインキナーゼc阻害物質
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5472183A (en) * 1994-03-17 1995-12-05 Nisca Corporation Sheet feeding device with multiple sheet stackers
US5559228A (en) * 1995-03-30 1996-09-24 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5696949A (en) * 1995-06-15 1997-12-09 Intel Corporation System for PCI slots expansion using asynchronous PCI-to-PCI bridge with clock generator for providing clock signal to the expansion mother board and expansion side of bridge

Also Published As

Publication number Publication date
JP3235840B2 (ja) 2001-12-04
NO985080D0 (no) 1998-10-30
KR20000065137A (ko) 2000-11-06
NZ332658A (en) 2000-05-26
US5936084A (en) 1999-08-10
EP0805158A3 (en) 1998-04-01
EP0805158B1 (en) 2002-01-16
DK0805158T3 (da) 2002-03-18
DE69709568D1 (de) 2002-02-21
NO310416B1 (no) 2001-07-02
DE69709568T2 (de) 2002-09-05
TR199802193T2 (xx) 1999-02-22
AU703395B2 (en) 1999-03-25
CZ347098A3 (cs) 1999-06-16
CA2252701A1 (en) 1997-11-06
AU2929297A (en) 1997-11-19
WO1997041127A1 (en) 1997-11-06
PL329681A1 (en) 1999-04-12
BR9709301A (pt) 1999-08-10
CA2252701C (en) 2003-10-28
EA001450B1 (ru) 2001-04-23
IL126762A0 (en) 1999-08-17
ES2170918T3 (es) 2002-08-16
JPH11509233A (ja) 1999-08-17
ATE212026T1 (de) 2002-02-15
EP0805158A2 (en) 1997-11-05
NO985080L (no) 1998-12-08
EA199800966A1 (ru) 1999-04-29
PT805158E (pt) 2002-06-28

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