NO20021367D0 - Indolyl-3-glyoksylsyrederivater som har terapeutisk verdifulle egenskaper - Google Patents

Indolyl-3-glyoksylsyrederivater som har terapeutisk verdifulle egenskaper

Info

Publication number
NO20021367D0
NO20021367D0 NO20021367A NO20021367A NO20021367D0 NO 20021367 D0 NO20021367 D0 NO 20021367D0 NO 20021367 A NO20021367 A NO 20021367A NO 20021367 A NO20021367 A NO 20021367A NO 20021367 D0 NO20021367 D0 NO 20021367D0
Authority
NO
Norway
Prior art keywords
indolyl
acid derivatives
glyoxylic acid
therapeutically valuable
valuable properties
Prior art date
Application number
NO20021367A
Other languages
English (en)
Other versions
NO20021367L (no
NO322614B1 (no
Inventor
Bernd Nickel
Thomas Klenner
Gerald Bacher
Thomas Beckers
Peter Emig
Juergen Engel
Erik Bruyneel
Guenter Kam
Kirsten Peters
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of NO20021367D0 publication Critical patent/NO20021367D0/no
Publication of NO20021367L publication Critical patent/NO20021367L/no
Publication of NO322614B1 publication Critical patent/NO322614B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20021367A 1999-09-28 2002-03-19 Indolyl-3-glykosylsyrederivater som har terapeutisk verdifulle egenskaper NO322614B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (de) 1999-09-28 2000-09-26 Indolyl-3-glyoxylsäurederivate als antitumormittel

Publications (3)

Publication Number Publication Date
NO20021367D0 true NO20021367D0 (no) 2002-03-19
NO20021367L NO20021367L (no) 2002-05-22
NO322614B1 NO322614B1 (no) 2006-11-06

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021367A NO322614B1 (no) 1999-09-28 2002-03-19 Indolyl-3-glykosylsyrederivater som har terapeutisk verdifulle egenskaper

Country Status (32)

Country Link
EP (1) EP1218006B1 (no)
JP (1) JP2003510274A (no)
KR (1) KR100759242B1 (no)
CN (1) CN1301712C (no)
AR (1) AR025885A1 (no)
AT (1) ATE459356T1 (no)
AU (1) AU783436B2 (no)
BG (1) BG106639A (no)
BR (1) BR0014378A (no)
CA (1) CA2386069C (no)
CZ (1) CZ303246B6 (no)
DE (1) DE50015879D1 (no)
DZ (1) DZ3196A1 (no)
EE (1) EE200200169A (no)
ES (1) ES2342042T3 (no)
GE (1) GEP20043250B (no)
HK (1) HK1048941B (no)
HR (1) HRP20020369A2 (no)
HU (1) HUP0202788A3 (no)
IL (2) IL148670A0 (no)
IS (1) IS6319A (no)
MX (1) MXPA02002824A (no)
NO (1) NO322614B1 (no)
NZ (1) NZ517988A (no)
PL (1) PL199576B1 (no)
RS (1) RS51302B (no)
RU (1) RU2282444C2 (no)
SK (1) SK287533B6 (no)
TW (1) TWI269654B (no)
UA (1) UA75872C2 (no)
WO (1) WO2001022954A2 (no)
ZA (1) ZA200202556B (no)

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DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
CN1431999A (zh) 2000-05-31 2003-07-23 阿斯特拉曾尼卡有限公司 具有血管损伤活性的吲哚衍生物
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1484329A1 (de) * 2003-06-06 2004-12-08 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
KR101132599B1 (ko) * 2003-06-05 2012-06-21 아에테르나 젠타리스 게엠베하 아폽토시스 유도 효과를 갖는 인돌 유도체
EP1595878A1 (de) * 2004-05-15 2005-11-16 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
WO2005115992A1 (en) * 2004-05-23 2005-12-08 Housey Pharmaceuticals, Inc. Theramutein modulators
BRPI0517652A (pt) * 2004-11-08 2008-10-14 Baxter Healthcare Sa composições farmacêuticas nanoparticuladas de inibidores de tubulina, métodos para as suas preparações e respectivos usos
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
CN103102303B (zh) 2004-12-31 2015-10-28 雷迪博士实验室有限公司 作为cetp抑制剂的苄胺衍生物
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US20080241274A1 (en) * 2006-11-28 2008-10-02 Ziopharm Oncology, Inc. Indibulin therapy
KR101774223B1 (ko) 2011-08-18 2017-09-12 닥터 레디스 레보러터리즈 리미티드 콜레스테릴 에스테르-전달 단백질(cetp) 억제제인 치환된 헤테로시클릭 아민 화합물
AU2012313971B2 (en) 2011-09-27 2016-09-29 Dr. Reddy's Laboratories, Ltd. 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
WO2014144715A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
JP3163631B2 (ja) * 1992-10-20 2001-05-08 東レ株式会社 好酸球浸潤抑制剤
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
AU6523598A (en) 1997-04-08 1998-10-30 Banyu Pharmaceutical Co., Ltd. Cancerous metastasis-associated gene
GEP20032920B (en) * 1998-02-25 2003-03-25 Genetics Inst Inhibitors of Phospholipase Enzymes
JP2004500308A (ja) * 1998-03-12 2004-01-08 ノボ　ノルディスク　アクティーゼルスカブ プロテインチロシンホスアターゼのモジュレーター
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
WO1999055696A1 (de) * 1998-04-28 1999-11-04 Arzneimittelwerk Dresden Gmbh Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
NZ517988A (en) 2004-10-29
PL199576B1 (pl) 2008-10-31
HUP0202788A3 (en) 2003-02-28
BR0014378A (pt) 2003-07-29
CA2386069A1 (en) 2001-04-05
SK4072002A3 (en) 2003-11-04
BG106639A (bg) 2002-12-29
GEP20043250B (en) 2004-06-25
AU7782900A (en) 2001-04-30
ES2342042T3 (es) 2010-07-01
RU2282444C2 (ru) 2006-08-27
KR20030019295A (ko) 2003-03-06
WO2001022954A3 (de) 2002-03-28
UA75872C2 (en) 2006-06-15
MXPA02002824A (es) 2003-07-21
EP1218006A2 (de) 2002-07-03
EE200200169A (et) 2003-04-15
SK287533B6 (sk) 2011-01-04
YU22702A (sh) 2004-12-31
CN1301712C (zh) 2007-02-28
HK1048941B (zh) 2007-09-21
RS51302B (sr) 2010-12-31
DE50015879D1 (de) 2010-04-15
CA2386069C (en) 2012-08-14
CN1376064A (zh) 2002-10-23
AR025885A1 (es) 2002-12-18
NO20021367L (no) 2002-05-22
EP1218006B1 (de) 2010-03-03
TWI269654B (en) 2007-01-01
KR100759242B1 (ko) 2007-09-18
IS6319A (is) 2002-03-21
HK1048941A1 (en) 2003-04-25
IL148670A (en) 2009-09-01
NO322614B1 (no) 2006-11-06
IL148670A0 (en) 2002-09-12
JP2003510274A (ja) 2003-03-18
WO2001022954A2 (de) 2001-04-05
CZ20021005A3 (cs) 2004-01-14
CZ303246B6 (cs) 2012-06-20
ATE459356T1 (de) 2010-03-15
AU783436B2 (en) 2005-10-27
DZ3196A1 (fr) 2001-04-05
HRP20020369A2 (en) 2004-12-31
ZA200202556B (en) 2003-08-27
HUP0202788A2 (hu) 2003-01-28
PL364811A1 (en) 2004-12-13

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Legal Events

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MM1K Lapsed by not paying the annual fees