MXPA00010070A - Mejora de respuestas inmunes medidas de proteina de fusion anticuerpo-citoquina por co-administracion con inhibidor de angiogenesis. - Google Patents

Mejora de respuestas inmunes medidas de proteina de fusion anticuerpo-citoquina por co-administracion con inhibidor de angiogenesis.

Info

Publication number
MXPA00010070A
MXPA00010070A MXPA00010070A MXPA00010070A MXPA00010070A MX PA00010070 A MXPA00010070 A MX PA00010070A MX PA00010070 A MXPA00010070 A MX PA00010070A MX PA00010070 A MXPA00010070 A MX PA00010070A MX PA00010070 A MXPA00010070 A MX PA00010070A
Authority
MX
Mexico
Prior art keywords
angiogenesis inhibitor
antibody
enhancement
administration
fusion protein
Prior art date
Application number
MXPA00010070A
Other languages
English (en)
Inventor
Stephen D Gillies
Original Assignee
Lexigen Pharm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexigen Pharm Corp filed Critical Lexigen Pharm Corp
Publication of MXPA00010070A publication Critical patent/MXPA00010070A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

Se describen composiciones y metodos para mejorar una respuesta inmune citocidal dirigida contra un tipo celular preseleccionado en un mamifero. Los metodos y composiciones dependen de una combinacion de un inmunoconjugado anticuerpo- citoquina y un inhibidor de angiogenesis. Una vez administrado al mamifero, el inmunoconjugado induce una respuesta inmune contra el tipo celular preseleccionado, por ejemplo, una celula cancerosa la cual, como resultado de la sinergia con el inhibidor de angiogenesis, es mayor que la respuesta inmune inducida por el inmunoconjugado solo. Los metodos y composiciones son particularmente utiles al eliminar tumores solidos o celulas viralmente infectadas en un mamifero.
MXPA00010070A 1998-04-15 1999-04-15 Mejora de respuestas inmunes medidas de proteina de fusion anticuerpo-citoquina por co-administracion con inhibidor de angiogenesis. MXPA00010070A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8186398P 1998-04-15 1998-04-15
PCT/US1999/008335 WO1999052562A2 (en) 1998-04-15 1999-04-15 Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor

Publications (1)

Publication Number Publication Date
MXPA00010070A true MXPA00010070A (es) 2004-03-10

Family

ID=22166892

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA00010070A MXPA00010070A (es) 1998-04-15 1999-04-15 Mejora de respuestas inmunes medidas de proteina de fusion anticuerpo-citoquina por co-administracion con inhibidor de angiogenesis.

Country Status (19)

Country Link
US (1) US20040180035A1 (es)
EP (1) EP1071468B1 (es)
JP (1) JP2002511432A (es)
CN (1) CN1318092C (es)
AT (1) ATE329622T1 (es)
AU (1) AU758860B2 (es)
BR (1) BR9909583A (es)
CA (1) CA2328076C (es)
CZ (1) CZ20003767A3 (es)
DE (1) DE69931908T2 (es)
ES (1) ES2267263T3 (es)
HK (1) HK1038882A1 (es)
HU (1) HUP0101352A3 (es)
MX (1) MXPA00010070A (es)
NO (1) NO20005155L (es)
PL (1) PL343462A1 (es)
RU (1) RU2229305C2 (es)
WO (1) WO1999052562A2 (es)
ZA (1) ZA200005475B (es)

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CN104830901A (zh) * 2015-01-21 2015-08-12 武汉友芝友生物制药有限公司 一种鼠肿瘤模型的构建方法及其应用
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Also Published As

Publication number Publication date
CA2328076C (en) 2009-10-06
NO20005155D0 (no) 2000-10-13
NO20005155L (no) 2000-12-13
CA2328076A1 (en) 1999-10-21
RU2229305C2 (ru) 2004-05-27
PL343462A1 (en) 2001-08-13
ES2267263T3 (es) 2007-03-01
HK1038882A1 (zh) 2002-04-04
JP2002511432A (ja) 2002-04-16
CZ20003767A3 (cs) 2002-01-16
DE69931908T2 (de) 2007-01-11
US20040180035A1 (en) 2004-09-16
EP1071468A2 (en) 2001-01-31
AU3565099A (en) 1999-11-01
WO1999052562A3 (en) 1999-11-18
BR9909583A (pt) 2002-01-15
WO1999052562A2 (en) 1999-10-21
ZA200005475B (en) 2001-11-13
AU758860B2 (en) 2003-04-03
DE69931908D1 (de) 2006-07-27
CN1318092C (zh) 2007-05-30
HUP0101352A3 (en) 2003-08-28
CN1305386A (zh) 2001-07-25
HUP0101352A2 (hu) 2001-08-28
ATE329622T1 (de) 2006-07-15
EP1071468B1 (en) 2006-06-14

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