ATE190659T1 - Rekombinante immuntoxine - Google Patents

Rekombinante immuntoxine

Info

Publication number
ATE190659T1
ATE190659T1 AT92921866T AT92921866T ATE190659T1 AT E190659 T1 ATE190659 T1 AT E190659T1 AT 92921866 T AT92921866 T AT 92921866T AT 92921866 T AT92921866 T AT 92921866T AT E190659 T1 ATE190659 T1 AT E190659T1
Authority
AT
Austria
Prior art keywords
recombinant
immuntoxins
relates
immunotoxins
pe38kdel
Prior art date
Application number
AT92921866T
Other languages
English (en)
Inventor
Ira Pastan
Mark Willingham
David Fitzgerald
Uli Brinkmann
Lee Pai
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE190659T1 publication Critical patent/ATE190659T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
AT92921866T 1991-09-30 1992-09-29 Rekombinante immuntoxine ATE190659T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76733191A 1991-09-30 1991-09-30
PCT/US1992/008257 WO1993007286A1 (en) 1991-09-30 1992-09-29 Recombinant immunotoxins

Publications (1)

Publication Number Publication Date
ATE190659T1 true ATE190659T1 (de) 2000-04-15

Family

ID=25079156

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92921866T ATE190659T1 (de) 1991-09-30 1992-09-29 Rekombinante immuntoxine

Country Status (8)

Country Link
EP (1) EP0610286B1 (de)
JP (1) JP3512795B2 (de)
AT (1) ATE190659T1 (de)
AU (1) AU675413B2 (de)
CA (1) CA2120153C (de)
DE (1) DE69230798T2 (de)
DK (1) DK0610286T3 (de)
WO (1) WO1993007286A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981726A (en) * 1990-10-12 1999-11-09 The United States Of America As Represented By The Department Of Health And Human Services Chimeric and mutationally stabilized tumor-specific B1, B3 and B5 antibody fragments; immunotoxic fusion proteins; and uses thereof
US5889157A (en) 1990-10-12 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Humanized B3 antibody fragments, fusion proteins, and uses thereof
US5608039A (en) * 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
KR100254759B1 (ko) * 1992-01-23 2000-05-01 플레믹 크리스티안 단량체 및 이량체 항체-단편 융합 단백질
PT651805E (pt) * 1992-07-17 2007-02-28 Dana Farber Cancer Inst Inc Método de ligação intracelular de moléculas-alvo
US5747654A (en) 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
FR2706486B1 (fr) * 1993-06-16 1995-09-01 Rhone Poulenc Rorer Sa Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
US5851829A (en) * 1993-07-16 1998-12-22 Dana-Farber Cancer Institute Method of intracellular binding of target molecules
AU717611B2 (en) * 1994-10-28 2000-03-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Tumor-specific antibody fragments, fusion proteins, and uses thereof
WO1996038571A2 (en) * 1995-05-31 1996-12-05 Regents Of The University Of Minnesota Recombinant polypeptide cytotoxins for cancer treatment
JPH11513669A (ja) * 1995-10-13 1999-11-24 アメリカ合衆国 ジスルフィド安定化抗体フラグメントを含む免疫毒素
JP4124486B2 (ja) 1996-05-22 2008-07-23 ビベンティア バイオテック インコーポレイテッド ガン細胞を特異的に検出する抗原結合フラグメント、このフラグメントをコードするヌクレオチド、ならびにガンの予防および検出のためのその使用
ATE403714T1 (de) 1996-11-06 2008-08-15 Univ California Tumor necrosis factor rezeptor abspaltendes enzym,dessen zubereitungen und verwendungen
US7115722B1 (en) 1997-05-22 2006-10-03 Viventia Biotech, Inc. Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
AU753310B2 (en) 1998-05-20 2002-10-17 Chugai Seiyaku Kabushiki Kaisha Novel method for gene cloning
US7030228B1 (en) 1999-11-15 2006-04-18 Miltenyi Biotec Gmbh Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby
EP1969165A4 (de) * 2005-12-23 2010-05-19 Viventia Biotech Inc Verfahren zum generieren und screenen von fusionsproteinbibliotheken und verwendungen davon
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053911C (en) * 1989-04-21 1999-11-02 Ira H. Pastan Recombinant antibody-toxin fusion protein

Also Published As

Publication number Publication date
JPH07502643A (ja) 1995-03-23
CA2120153A1 (en) 1993-04-15
DK0610286T3 (da) 2000-07-17
EP0610286A1 (de) 1994-08-17
CA2120153C (en) 2006-06-06
EP0610286B1 (de) 2000-03-15
DE69230798D1 (de) 2000-04-20
AU2779892A (en) 1993-05-03
JP3512795B2 (ja) 2004-03-31
EP0610286A4 (en) 1995-10-25
WO1993007286A1 (en) 1993-04-15
DE69230798T2 (de) 2000-08-03
AU675413B2 (en) 1997-02-06

Similar Documents

Publication Publication Date Title
ATE190659T1 (de) Rekombinante immuntoxine
NO844579L (no) Enzymresistente immunomodulerende peptider.
ES2066603T3 (es) Fungicidas de 3-difluorometilpirazolcarboxamida.
BR0112111A (pt) Realce de respostas imunes mediadas por proteìna de fusão de anticorpo-citocina por tratamento combinado com agentes de realce de captação de imunocitocina
ES8602768A1 (es) Un procedimiento para la preparacion de nuevas n-(heterociclil biciclo)-4-piperidinaminas.
YU17092A (sh) Derivati 2,4-diaminohinazolina
DE122006000010I2 (de) Benzocyclobutyl- oder Indanyl-Alkyl-Amino-Alkyl substituierte 3-Benzazepin-2-ones, verwendbar in derBehandlung von kardiovaskularen Krankheiten
DE69131200D1 (en) Herpes simplex virus vp16 impfstoffe
DK0668769T3 (da) Egebarkekstrakt-relaterede syntetiske sammensætninger og fremgangsmåde til deres anvendelse
EP0552296A4 (en) Mouse monoclonal antibodies
DE69434384D1 (de) Metalkomplexbildner
ATE199167T1 (de) Nichtglykosyliertes fgf-4 und dieses enthaltende präparate
DK0563085T3 (da) Hidtil ukendte præparater
EP0311616A4 (de) Kombination von gammainterferonen und antientzündungsmitteln oder antipyretischen mitteln zur behandlung von krankheiten.
DE69106361T2 (de) Einschlusskomplex von nimesulide mit cyclodextrinen.
DK1431391T3 (da) RANTES-mutanter og terapeutiske anvendelser heraf
FI961339A0 (fi) Triaryylieteenijohdannaiset käytettäväksi hoidossa
ATE130304T1 (de) Neue alpha-glukosidaseinhibitoren.
SE8900564D0 (sv) Novel medicinal use
IT9047812A0 (it) Complesso per la stabilizzazione del rachide dorso-lombo-sacrale e relativo metodo di stabilizzazione.
ITMI911597A1 (it) Composizione di trattamento di acque di rifiuto da destinare al riciclo, e procedimento di riciclo di acque di rifiuto che utilizza questa composizione.
ITFE930013U1 (it) Bacchette orientali meccanizzate.
IT8459312V0 (it) Massaggiatore manuale in fibra intrecciata di tipo perfezionato.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties