EA200500210A1 - Конъюгаты стероидов, их получение и их применение - Google Patents

Конъюгаты стероидов, их получение и их применение

Info

Publication number
EA200500210A1
EA200500210A1 EA200500210A EA200500210A EA200500210A1 EA 200500210 A1 EA200500210 A1 EA 200500210A1 EA 200500210 A EA200500210 A EA 200500210A EA 200500210 A EA200500210 A EA 200500210A EA 200500210 A1 EA200500210 A1 EA 200500210A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conjugates
application
receiving
taxol
steroid conjugates
Prior art date
Application number
EA200500210A
Other languages
English (en)
Inventor
Элиас Кастанас
Original Assignee
Медексис С. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медексис С. А. filed Critical Медексис С. А.
Priority claimed from PCT/IB2003/002785 external-priority patent/WO2004006966A1/en
Publication of EA200500210A1 publication Critical patent/EA200500210A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Раскрыты конъюгаты, включающие один или более стероидов, конъюгированных с одним или более белками млекопитающих. Конъюгаты можно применять для диагностики или лечения солидной раковой опухоли и гематологических злокачественных заболеваний. Кроме того, конъюгаты проявляют синергическое действие вместе с препаратом, действующим на клеточный каркас, таким как таксол, что обеспечивает возможность лечения раковых опухолей, которые иначе не реагировали бы на таксол.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500210A 2002-07-16 2003-07-14 Конъюгаты стероидов, их получение и их применение EA200500210A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20020100335 2002-07-16
PCT/IB2003/002785 WO2004006966A1 (en) 2002-07-16 2003-07-14 Steroid conjugates, preparation thereof and the use thereof

Publications (1)

Publication Number Publication Date
EA200500210A1 true EA200500210A1 (ru) 2005-06-30

Family

ID=36441275

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500210A EA200500210A1 (ru) 2002-07-16 2003-07-14 Конъюгаты стероидов, их получение и их применение

Country Status (7)

Country Link
US (2) US7358379B2 (ru)
AU (1) AU2003281165B2 (ru)
BR (1) BR0312690A (ru)
CA (1) CA2492297A1 (ru)
EA (1) EA200500210A1 (ru)
MX (1) MXPA05000615A (ru)
PL (1) PL375363A1 (ru)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215102A (en) 1979-01-05 1980-07-29 Lee Sin H Cytochemical agents and methods for the detection of steroid hormone receptors in human tissues
NZ196126A (en) 1980-02-07 1985-05-31 Commw Scient Ind Res Org Increasing ovulation rate in female cattle
US5157049A (en) 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5834213A (en) 1991-05-02 1998-11-10 Baylor College Of Medicine Screening system and assay for identifying compounds that regulate steroid and orphan receptors mediation of DNA transcription
WO1993002691A1 (en) 1991-08-09 1993-02-18 Mount Sinai School Of Medicine Of The City University Of New York Steroid hormone drug delivery
US5248796A (en) 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
HUP9701554D0 (en) 1997-09-18 1997-11-28 Human Oltoanyagtermeloe Gyogys Pharmaceutical composition containing plazma proteins
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6416737B1 (en) * 1998-11-19 2002-07-09 Board Of Trustees Of The University Of Arkansas Increasing bone strength with selected bisphosphonates
EP1104667A1 (en) 1999-11-29 2001-06-06 The Procter & Gamble Company Disposable absorbant article having fecal management layer
NO314537B1 (no) 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
GB0010683D0 (en) 2000-05-03 2000-06-28 Univ Bristol Cancer therapy
HU229207B1 (en) * 2000-09-14 2013-09-30 Univ British Columbia Antisense insulin-like growth factor binding protein (igfbp)-2-oligodeoxynucleotides for prostate and other endocrine regulated tumor therapy
US7199115B2 (en) * 2004-04-19 2007-04-03 Schering Ag 17α-fluorosteroids, pharmaceutical compositions containing 17α-fluorosteroids and a method of making them

Also Published As

Publication number Publication date
US7358379B2 (en) 2008-04-15
AU2003281165B2 (en) 2006-08-03
PL375363A1 (en) 2005-11-28
US20060178295A1 (en) 2006-08-10
US20080267875A1 (en) 2008-10-30
AU2003281165A1 (en) 2004-02-02
BR0312690A (pt) 2005-05-03
MXPA05000615A (es) 2005-11-17
CA2492297A1 (en) 2004-01-22

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