DE69931908D1 - Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor - Google Patents

Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor

Info

Publication number
DE69931908D1
DE69931908D1 DE69931908T DE69931908T DE69931908D1 DE 69931908 D1 DE69931908 D1 DE 69931908D1 DE 69931908 T DE69931908 T DE 69931908T DE 69931908 T DE69931908 T DE 69931908T DE 69931908 D1 DE69931908 D1 DE 69931908D1
Authority
DE
Germany
Prior art keywords
immune response
antibody
administration
increasing
fusion protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69931908T
Other languages
English (en)
Other versions
DE69931908T2 (de
Inventor
D Gillies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
EMD Serono Research Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EMD Serono Research Center Inc filed Critical EMD Serono Research Center Inc
Application granted granted Critical
Publication of DE69931908D1 publication Critical patent/DE69931908D1/de
Publication of DE69931908T2 publication Critical patent/DE69931908T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
DE69931908T 1998-04-15 1999-04-15 Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor Expired - Lifetime DE69931908T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8186398P 1998-04-15 1998-04-15
US81863P 1998-04-15
PCT/US1999/008335 WO1999052562A2 (en) 1998-04-15 1999-04-15 Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor

Publications (2)

Publication Number Publication Date
DE69931908D1 true DE69931908D1 (de) 2006-07-27
DE69931908T2 DE69931908T2 (de) 2007-01-11

Family

ID=22166892

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69931908T Expired - Lifetime DE69931908T2 (de) 1998-04-15 1999-04-15 Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor

Country Status (19)

Country Link
US (1) US20040180035A1 (de)
EP (1) EP1071468B1 (de)
JP (1) JP2002511432A (de)
CN (1) CN1318092C (de)
AT (1) ATE329622T1 (de)
AU (1) AU758860B2 (de)
BR (1) BR9909583A (de)
CA (1) CA2328076C (de)
CZ (1) CZ20003767A3 (de)
DE (1) DE69931908T2 (de)
ES (1) ES2267263T3 (de)
HK (1) HK1038882A1 (de)
HU (1) HUP0101352A3 (de)
MX (1) MXPA00010070A (de)
NO (1) NO20005155L (de)
PL (1) PL343462A1 (de)
RU (1) RU2229305C2 (de)
WO (1) WO1999052562A2 (de)
ZA (1) ZA200005475B (de)

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EP1699822B1 (de) 2003-12-30 2008-04-23 MERCK PATENT GmbH Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung
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EA011859B9 (ru) 2004-01-05 2013-07-30 Емд Лексиген Ресерч Сентер Корп. Соединения для адресной доставки препарата к ткани или органу-мишени
PL1706428T3 (pl) 2004-01-22 2010-02-26 Merck Patent Gmbh Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
CN101072793B (zh) * 2004-12-09 2012-06-20 默克专利有限公司 具有降低的免疫原性的il-7变体
BRPI0617688A2 (pt) 2005-10-21 2011-06-07 Hoffmann La Roche método para expressão recombinante de um polipeptìdeo
EA016429B1 (ru) 2005-12-30 2012-04-30 Мерк Патент Гмбх Антитела против cd19 с пониженной иммуногенностью
ATE555125T1 (de) * 2005-12-30 2012-05-15 Merck Patent Gmbh Interleukin-12p40-varianten mit verbesserter stabilität
GB2441789B (en) * 2006-09-18 2012-03-28 Angus Buchan Gordon Use of a Tumour Volume Measuring Device
CA2759333A1 (en) 2009-04-22 2010-10-28 Merck Patent Gmbh Antibody fusion proteins with modified fcrn binding sites
EP2561888A1 (de) * 2011-08-23 2013-02-27 Deutsches Krebsforschungszentrum Protein enthaltend NC-1 zur Behandlung von Erkrankungen in Bezug auf Angiogenese
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
CN104830901A (zh) * 2015-01-21 2015-08-12 武汉友芝友生物制药有限公司 一种鼠肿瘤模型的构建方法及其应用
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
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Also Published As

Publication number Publication date
NO20005155L (no) 2000-12-13
CA2328076A1 (en) 1999-10-21
CA2328076C (en) 2009-10-06
HUP0101352A2 (hu) 2001-08-28
AU758860B2 (en) 2003-04-03
EP1071468B1 (de) 2006-06-14
ZA200005475B (en) 2001-11-13
CZ20003767A3 (cs) 2002-01-16
HUP0101352A3 (en) 2003-08-28
NO20005155D0 (no) 2000-10-13
RU2229305C2 (ru) 2004-05-27
US20040180035A1 (en) 2004-09-16
DE69931908T2 (de) 2007-01-11
WO1999052562A2 (en) 1999-10-21
ATE329622T1 (de) 2006-07-15
PL343462A1 (en) 2001-08-13
WO1999052562A3 (en) 1999-11-18
JP2002511432A (ja) 2002-04-16
MXPA00010070A (es) 2004-03-10
AU3565099A (en) 1999-11-01
CN1305386A (zh) 2001-07-25
HK1038882A1 (zh) 2002-04-04
BR9909583A (pt) 2002-01-15
EP1071468A2 (de) 2001-01-31
CN1318092C (zh) 2007-05-30
ES2267263T3 (es) 2007-03-01

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