MX360598B - Inhibidores de bromodominio de benzo [c] isoxazoloazepina y sus usos. - Google Patents

Inhibidores de bromodominio de benzo [c] isoxazoloazepina y sus usos.

Info

Publication number
MX360598B
MX360598B MX2014015004A MX2014015004A MX360598B MX 360598 B MX360598 B MX 360598B MX 2014015004 A MX2014015004 A MX 2014015004A MX 2014015004 A MX2014015004 A MX 2014015004A MX 360598 B MX360598 B MX 360598B
Authority
MX
Mexico
Prior art keywords
benzo
bromodomain inhibitors
isoxazoloazepine
inhibitors
present
Prior art date
Application number
MX2014015004A
Other languages
English (en)
Other versions
MX2014015004A (es
Inventor
Brian K Albrecht
Victor S Gehling
Rishi G Vaswani
Michael Charles Hewitt
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of MX2014015004A publication Critical patent/MX2014015004A/es
Publication of MX360598B publication Critical patent/MX360598B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

La presente invención se refiere a compuestos útiles como inhibidores de proteínas que contienen bromodominio; la invención también proporciona composiciones farmacéuticamente aceptables que comprenden compuestos de la presente invención y métodos para usar dichas composiciones en el tratamiento de diversos trastornos.
MX2014015004A 2012-06-06 2013-06-06 Inhibidores de bromodominio de benzo [c] isoxazoloazepina y sus usos. MX360598B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261656205P 2012-06-06 2012-06-06
PCT/US2013/044444 WO2013184876A1 (en) 2012-06-06 2013-06-06 Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
MX2014015004A MX2014015004A (es) 2015-03-05
MX360598B true MX360598B (es) 2018-11-08

Family

ID=48626693

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015004A MX360598B (es) 2012-06-06 2013-06-06 Inhibidores de bromodominio de benzo [c] isoxazoloazepina y sus usos.

Country Status (20)

Country Link
US (2) US9493483B2 (es)
EP (1) EP2859000B1 (es)
JP (1) JP6154004B2 (es)
KR (1) KR20150023562A (es)
CN (1) CN104428304B (es)
AR (1) AR091285A1 (es)
AU (1) AU2013271569B2 (es)
BR (1) BR112014030165A2 (es)
CA (1) CA2874774C (es)
EA (1) EA026894B1 (es)
ES (1) ES2632774T3 (es)
HK (1) HK1207372A1 (es)
IL (1) IL235844A (es)
IN (1) IN2014DN10386A (es)
MX (1) MX360598B (es)
NZ (1) NZ702458A (es)
SG (1) SG11201407900WA (es)
TW (1) TWI602820B (es)
WO (1) WO2013184876A1 (es)
ZA (1) ZA201408720B (es)

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CN109963570A (zh) 2017-01-21 2019-07-02 宁波知明生物科技有限公司 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用
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AU2013271569B2 (en) 2017-09-14
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AU2013271569A1 (en) 2014-12-18
CN104428304A (zh) 2015-03-18
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