PE20000944A1 - Derivados de sulfonamida - Google Patents
Derivados de sulfonamidaInfo
- Publication number
- PE20000944A1 PE20000944A1 PE1999000767A PE00076799A PE20000944A1 PE 20000944 A1 PE20000944 A1 PE 20000944A1 PE 1999000767 A PE1999000767 A PE 1999000767A PE 00076799 A PE00076799 A PE 00076799A PE 20000944 A1 PE20000944 A1 PE 20000944A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- disorder
- azethydinyl
- pyrrolidinyl
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE SULFONAMIDA DE FORMULA (R1)(Ra)(Rb)-C-CH2-NHSO2R2, DONDE UNO O DOS DE Ra Y Rb SON F, CF3, -ORc; Rc ES H, ALQUILO C1-C4, Y EL OTRO ES H o FORMAN JUNTOS =O, =CH2; R1 ES NAFTILO, FENILO, FURILO, TIENILO, PIRIDILO OPCIONALMENTE SUSTITUIDO POR 1-2 HALOGENO, NITRO, ALQUILO C1-C10, (CH2)yX1R9, ENTRE OTROS; y ES 0-4; X1 ES O, S, NR10, CO, CONR11, NR12CO, OCONR13, ENTRE OTROS; R9 ES H, ALQUILO C1-C10, ALQUENILO C3-C10, ENTRE OTROS; R10, R11, R12, R13 SON H, ALQUILO C1-C10 o R9, R10, R11, R12 O R13 FORMAN JUNTO CON N UN GRUPO AZETIDINILO, PIRROLIDINILO, PIPERIDINILO, R14-(La)n-X2-(Lb)m, ENTRE OTROS; X2 ES UN ENLACE, O, NH, S, SO, SO2, ENTRE OTROS; La Y Lb SON ALQUILENO C1-C4; UNO DE n Y m ES 0-1 Y EL OTRO ES 0; R14 ES FENILO, ANILLO HETEROAROMATICO OPCIONALMENTE SUSTITUIDO POR HALOGENO, NITRO, CIANO, (CH2)zX3R15; ENTRE OTROS; z ES 0-4; X3 ES O, S, NR16, CO, ENTRE OTROS; R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, NR3R4, ENTRE OTROS; R3 Y R4 SON ALQUILO C1-C4 O JUNTO CON N FORMAN UN GRUPO AZETIDINILO, PIRROLIDINILO, PIPERIDINILO. UN COMPUESTO PREFERIDO A. EL DERIVADO DE SULFONAMIDA ES UN POTENCIADOR DEL RECEPTOR DE GLUTAMATO POR LO QUE PUEDE SER UTIL PARA TRATAR UN TRASTORNO COGNITIVO, TRASTORNO NEURODEGENERATIVO, DEMENCIA, DEBILITAMIENTO DEBIDO A LA EDAD, TRASTORNO DEL MOVIMIENTO, MEJORAR LA MEMORIA Y APRENDIZAJE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9490598P | 1998-07-31 | 1998-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000944A1 true PE20000944A1 (es) | 2000-09-20 |
Family
ID=22247857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1999000767A PE20000944A1 (es) | 1998-07-31 | 1999-07-27 | Derivados de sulfonamida |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0980864A3 (es) |
JP (1) | JP2002521443A (es) |
AR (1) | AR021745A1 (es) |
AU (1) | AU5239799A (es) |
CA (1) | CA2338864A1 (es) |
CO (1) | CO5080788A1 (es) |
PE (1) | PE20000944A1 (es) |
SV (1) | SV1999000115A (es) |
WO (1) | WO2000006157A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
US6693137B1 (en) | 1998-07-31 | 2004-02-17 | Eli Lilly And Company | Sulphonamide derivatives |
IL146052A0 (en) | 1999-04-30 | 2002-07-25 | Lilly Co Eli | Monofluoroalkyl derivatives |
WO2001089510A2 (en) * | 2000-05-24 | 2001-11-29 | Eli Lilly And Company | Use of an ampa receptor potentiator for the treatment of obesity |
ES2236321T3 (es) * | 2000-10-13 | 2005-07-16 | Eli Lilly And Company | Procedimiento para el tratamiento de la apoplejia. |
JP2004511540A (ja) | 2000-10-13 | 2004-04-15 | イーライ・リリー・アンド・カンパニー | シクロアルキルフルオロスルホンアミド誘導体 |
RU2403242C2 (ru) * | 2004-08-09 | 2010-11-10 | Глэксо Груп Лимитед | Соединения, которые усиливают рецептор глутамата, и их применение в медицине |
WO2010115952A1 (en) * | 2009-04-09 | 2010-10-14 | N.V. Organon | Indane derivatives |
WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
EP2705039B1 (en) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
JP2016521755A (ja) | 2013-06-13 | 2016-07-25 | ヴェロサイエンス,リミテッド・ライアビリティー・カンパニー | 代謝障害を治療するための組成物および方法 |
CA2952830C (en) | 2014-06-20 | 2022-11-01 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
DE68909958D1 (de) * | 1988-01-19 | 1993-11-25 | Tanabe Seiyaku Co | Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung. |
DE3819052A1 (de) * | 1988-06-04 | 1989-12-07 | Basf Ag | Neue sulfonamid-derivate, ihre herstellung und verwendung |
DE4114330A1 (de) * | 1991-05-02 | 1992-11-05 | Basf Ag | Neue arzneimittelkombination |
GB9702194D0 (en) * | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
-
1999
- 1999-07-27 PE PE1999000767A patent/PE20000944A1/es not_active Application Discontinuation
- 1999-07-28 AU AU52397/99A patent/AU5239799A/en not_active Abandoned
- 1999-07-28 CO CO99047633A patent/CO5080788A1/es unknown
- 1999-07-28 CA CA002338864A patent/CA2338864A1/en not_active Abandoned
- 1999-07-28 AR ARP990103723A patent/AR021745A1/es unknown
- 1999-07-28 SV SV1999000115A patent/SV1999000115A/es unknown
- 1999-07-28 WO PCT/US1999/017140 patent/WO2000006157A1/en active Application Filing
- 1999-07-28 JP JP2000562012A patent/JP2002521443A/ja not_active Withdrawn
- 1999-07-28 EP EP99306006A patent/EP0980864A3/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU5239799A (en) | 2000-02-21 |
EP0980864A3 (en) | 2003-07-09 |
JP2002521443A (ja) | 2002-07-16 |
EP0980864A2 (en) | 2000-02-23 |
CO5080788A1 (es) | 2001-09-25 |
AR021745A1 (es) | 2002-08-07 |
SV1999000115A (es) | 2000-04-11 |
WO2000006157A1 (en) | 2000-02-10 |
CA2338864A1 (en) | 2000-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |