DE69619711T2 - Retinoid-potenzierende verbindungen - Google Patents

Retinoid-potenzierende verbindungen

Info

Publication number
DE69619711T2
DE69619711T2 DE69619711T DE69619711T DE69619711T2 DE 69619711 T2 DE69619711 T2 DE 69619711T2 DE 69619711 T DE69619711 T DE 69619711T DE 69619711 T DE69619711 T DE 69619711T DE 69619711 T2 DE69619711 T2 DE 69619711T2
Authority
DE
Germany
Prior art keywords
hydrogen atom
alkyl group
represents hydrogen
retinoid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69619711T
Other languages
English (en)
Other versions
DE69619711D1 (de
Inventor
Koichi Shudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kemphys Ltd Setagaya Tokyo Jp
Original Assignee
Institute of Medicinal Molecular Design Inc IMMD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Medicinal Molecular Design Inc IMMD filed Critical Institute of Medicinal Molecular Design Inc IMMD
Application granted granted Critical
Publication of DE69619711D1 publication Critical patent/DE69619711D1/de
Publication of DE69619711T2 publication Critical patent/DE69619711T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thin Film Transistor (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69619711T 1995-09-21 1996-09-20 Retinoid-potenzierende verbindungen Expired - Lifetime DE69619711T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24263995 1995-09-21
JP15058296 1996-06-12
PCT/JP1996/002709 WO1997011061A1 (fr) 1995-09-21 1996-09-20 Composes a potentialisation de retinoide

Publications (2)

Publication Number Publication Date
DE69619711D1 DE69619711D1 (de) 2002-04-11
DE69619711T2 true DE69619711T2 (de) 2002-10-17

Family

ID=26480129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69619711T Expired - Lifetime DE69619711T2 (de) 1995-09-21 1996-09-20 Retinoid-potenzierende verbindungen

Country Status (13)

Country Link
US (3) US5929069A (de)
EP (1) EP0906907B1 (de)
KR (1) KR100484294B1 (de)
CN (1) CN1121395C (de)
AT (1) ATE214055T1 (de)
AU (1) AU7001596A (de)
CA (1) CA2233012A1 (de)
DE (1) DE69619711T2 (de)
DK (1) DK0906907T3 (de)
EA (1) EA002123B1 (de)
NO (1) NO981269L (de)
TW (1) TW420667B (de)
WO (1) WO1997011061A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE214055T1 (de) * 1995-09-21 2002-03-15 Inst Med Molecular Design Inc Retinoid-potenzierende verbindungen
WO1999024415A1 (fr) * 1997-11-12 1999-05-20 Institute Of Medicinal Molecular Design, Inc. Agonistes du recepteur du retinoide
JP4204657B2 (ja) 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
AU4314000A (en) 1999-04-28 2000-11-17 Institute Of Medicinal Molecular Design. Inc. Heterocyclic carboxylic acid derivatives
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
MXPA01011052A (es) * 1999-04-30 2002-11-22 Univ Michigan Aplicaciones terapeuticas de benzodiazepinas pro-apoctoticas.
CA2523986A1 (en) * 2003-03-20 2004-09-30 Research Foundation Itsuu Laboratory Method for forming organ
GB0308335D0 (en) 2003-04-10 2003-05-14 Novartis Ag Organic compounds
US8198329B2 (en) 2004-03-10 2012-06-12 Research Foundation Itsuu Laboratory Memory consolidation promoting agent and method of use
WO2005099759A1 (ja) * 2004-04-16 2005-10-27 Institute Of Medicinal Molecular Design. Inc. 動脈硬化症の予防及び／又は治療のための医薬
CA2611031A1 (en) 2005-06-01 2007-05-10 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
CN102058571B (zh) * 2005-09-09 2012-09-19 有限会社肯菲思 4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)氨基甲酰基]苯甲酸在制备用于预防及/或治疗肠疾病的药物中的应用
AU2006308655B2 (en) 2005-11-01 2010-09-23 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
MX2008015488A (es) 2006-06-09 2009-02-12 Univ Michigan Composiciones y metodos relacionados con compuestos novedosos y objetivos de los mismos.
JP2008081427A (ja) * 2006-09-27 2008-04-10 R&R Inc 分泌障害性疾患の予防及び／又は治療のための医薬
US7902260B2 (en) * 2007-02-28 2011-03-08 Kemphys Ltd. Medicament for preventive and/or therapeutic treatment of lower urinary tract symptom
CA2680017C (en) 2007-03-09 2013-11-12 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
CN101821229B (zh) 2007-08-15 2013-06-05 财团法人乙卯研究所 三环类胺化合物
AU2008298870C1 (en) 2007-09-14 2014-10-09 The Regents Of The University Of Michigan F1F0-ATPase inhibitors and related methods
US8188072B2 (en) 2007-11-06 2012-05-29 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
JP5567573B2 (ja) 2008-09-11 2014-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アリールグアニジンｆ１ｆ０−ａｔｐアーゼ阻害剤およびそれと関連する方法
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
JP2013505258A (ja) 2009-09-18 2013-02-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ベンゾジアゼピノン化合物およびそれを使用する治療方法
US9062024B2 (en) 2009-09-28 2015-06-23 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and salt thereof, and a fungicide for agricultural and horticultural use
WO2011062766A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US20130324520A1 (en) * 2011-02-14 2013-12-05 Sloan-Kettering Institute For Cancer Research Rxrg modulators for the treatment of cancer
EP2705039B1 (de) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomainhemmer und ihre verwendung
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2864336B1 (de) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazolazepinbromdomänenhemmer und verwendungen davon
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
CN103304494B (zh) * 2013-06-20 2015-05-27 河北大学 茚(1,2-b)喹喔啉-11-酮肟衍生物及其制备方法和用途
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide
KR200489267Y1 (ko) 2018-09-20 2019-05-23 김은진 폭 조절형 옷걸이
KR200490993Y1 (ko) 2019-06-14 2020-02-04 이현봉 구김방지기능을 구비한 바지걸이
CN114702454A (zh) * 2022-03-29 2022-07-05 江西师范大学 5-烷基-11-芳基-5H-二苯并[b,e][1,4]二氮杂卓衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211071A (ja) * 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
ATE214055T1 (de) * 1995-09-21 2002-03-15 Inst Med Molecular Design Inc Retinoid-potenzierende verbindungen
JP4204657B2 (ja) * 1997-12-05 2009-01-07 有限会社ケムフィズ 糖尿病の予防・治療剤

Also Published As

Publication number Publication date
US6476017B2 (en) 2002-11-05
EP0906907A1 (de) 1999-04-07
US20010039272A1 (en) 2001-11-08
US6121256A (en) 2000-09-19
DK0906907T3 (da) 2002-04-22
EP0906907A4 (de) 1999-04-07
NO981269L (no) 1998-05-20
NO981269D0 (no) 1998-03-20
DE69619711D1 (de) 2002-04-11
US5929069A (en) 1999-07-27
KR100484294B1 (ko) 2005-09-09
AU7001596A (en) 1997-04-09
ATE214055T1 (de) 2002-03-15
CA2233012A1 (en) 1997-03-27
EP0906907B1 (de) 2002-03-06
KR19990063661A (ko) 1999-07-26
CN1121395C (zh) 2003-09-17
TW420667B (en) 2001-02-01
EA199800318A1 (ru) 1998-10-29
EA002123B1 (ru) 2001-12-24
WO1997011061A1 (fr) 1997-03-27
CN1202160A (zh) 1998-12-16

Similar Documents

Publication Publication Date Title
DE69619711D1 (de) Retinoid-potenzierende verbindungen
PT976748E (pt) Derivados de pirrolidina com actividade inibidora de fosfolipase a2
DE69627985D1 (de) Heterozyklische verbindungen
EA199800109A1 (ru) Производные азетидинона для лечения атеросклероза
ES8702343A1 (es) Un procedimiento para la produccion de un derivado de diami-das de n-acilaminoacidos
DE69330593D1 (de) Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
ATE184605T1 (de) Methotrexat-derivate
ATE168679T1 (de) Neue tetracyclische verbindungen
DE69017774T2 (de) Benzothiazol-derivate als fungizide.
DE69311999T2 (de) Verfahren zur Herstellung von Amino-Thiadiazolylacetylhaliden
MX9600516A (es) [1,2,4]tiadiazoles herbicidas.
ATE206699T1 (de) Uch-15-verbindungen
ES2067388A1 (es) Procedimiento para la produccion de derivados de piroglutamato de configuracion 2,4-cis

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: KEMPHYS LTD., SETAGAYA, TOKYO, JP