MX357939B - Terapia de combinacion de inhibidor de objetivo de rapamicina en mamifero/janus cinasa (mtor/jak). - Google Patents
Terapia de combinacion de inhibidor de objetivo de rapamicina en mamifero/janus cinasa (mtor/jak).Info
- Publication number
- MX357939B MX357939B MX2013009351A MX2013009351A MX357939B MX 357939 B MX357939 B MX 357939B MX 2013009351 A MX2013009351 A MX 2013009351A MX 2013009351 A MX2013009351 A MX 2013009351A MX 357939 B MX357939 B MX 357939B
- Authority
- MX
- Mexico
- Prior art keywords
- combination therapy
- mtor
- jak inhibitor
- inhibitor combination
- jak
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporciona en la presente una terapia de combinación que comprende un inhibidor de mTOR y un inhibidor de JAK. La terapia de combinación es útil para el tratamiento de una variedad de cánceres, incluyendo MPN. La terapia de combinación es también útil para el tratamiento de cualquier número de enfermedades asociadas a JAK.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161444581P | 2011-02-18 | 2011-02-18 | |
US201161503789P | 2011-07-01 | 2011-07-01 | |
US201161503785P | 2011-07-01 | 2011-07-01 | |
PCT/US2012/025581 WO2012112847A1 (en) | 2011-02-18 | 2012-02-17 | mTOR/JAK INHIBITOR COMBINATION THERAPY |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013009351A MX2013009351A (es) | 2014-01-08 |
MX357939B true MX357939B (es) | 2018-07-31 |
Family
ID=45755586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013009351A MX357939B (es) | 2011-02-18 | 2012-02-17 | Terapia de combinacion de inhibidor de objetivo de rapamicina en mamifero/janus cinasa (mtor/jak). |
Country Status (14)
Country | Link |
---|---|
US (1) | US9993480B2 (es) |
EP (1) | EP2675451B9 (es) |
JP (1) | JP5936628B2 (es) |
KR (1) | KR102024948B1 (es) |
CN (1) | CN103732226B (es) |
AU (1) | AU2012219395B2 (es) |
BR (1) | BR112013020798B1 (es) |
CA (1) | CA2827673C (es) |
EA (1) | EA026317B1 (es) |
ES (1) | ES2547916T3 (es) |
MX (1) | MX357939B (es) |
PL (1) | PL2675451T3 (es) |
PT (1) | PT2675451E (es) |
WO (1) | WO2012112847A1 (es) |
Families Citing this family (43)
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CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
EP2740731B1 (en) | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
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DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
BRPI1012159B1 (pt) | 2009-05-22 | 2022-01-25 | Incyte Holdings Corporation | Compostos derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d] pirimidinas e pirrol-3-il-pirrolo[2,3-d] pirimidinas como inibidores de janus cinase, composições farmacêuticas compreendendo os referidos compostos e usos dos mesmos |
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- 2012-02-17 CN CN201280009417.3A patent/CN103732226B/zh active Active
- 2012-02-17 JP JP2013554626A patent/JP5936628B2/ja active Active
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- 2012-02-17 CA CA2827673A patent/CA2827673C/en active Active
- 2012-02-17 ES ES12705608.3T patent/ES2547916T3/es active Active
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WO2012112847A1 (en) | 2012-08-23 |
JP2014505735A (ja) | 2014-03-06 |
US20120214825A1 (en) | 2012-08-23 |
KR102024948B1 (ko) | 2019-11-04 |
ES2547916T3 (es) | 2015-10-09 |
PT2675451E (pt) | 2015-10-16 |
MX2013009351A (es) | 2014-01-08 |
CA2827673A1 (en) | 2012-08-23 |
CN103732226B (zh) | 2016-01-06 |
CA2827673C (en) | 2020-10-27 |
AU2012219395B2 (en) | 2017-05-25 |
US9993480B2 (en) | 2018-06-12 |
EA201391208A1 (ru) | 2013-12-30 |
EA026317B1 (ru) | 2017-03-31 |
JP5936628B2 (ja) | 2016-06-22 |
EP2675451A1 (en) | 2013-12-25 |
CN103732226A (zh) | 2014-04-16 |
BR112013020798A2 (pt) | 2016-10-04 |
KR20140082591A (ko) | 2014-07-02 |
EP2675451B1 (en) | 2015-06-24 |
AU2012219395A1 (en) | 2013-08-29 |
PL2675451T3 (pl) | 2016-05-31 |
BR112013020798B1 (pt) | 2022-03-15 |
EP2675451B9 (en) | 2017-07-26 |
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