MX350922B - Proceso para elaborar compuestos de isoquinolina. - Google Patents
Proceso para elaborar compuestos de isoquinolina.Info
- Publication number
- MX350922B MX350922B MX2015000505A MX2015000505A MX350922B MX 350922 B MX350922 B MX 350922B MX 2015000505 A MX2015000505 A MX 2015000505A MX 2015000505 A MX2015000505 A MX 2015000505A MX 350922 B MX350922 B MX 350922B
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- isoquinoline compounds
- making
- making isoquinoline
- hif
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Abstract
La presente invención se refiere a métodos para elaborar compuestos de isoquinolina y los compuestos intermediarios que se obtienen por ellos. Tales compuestos pueden usarse para preparar compuestos y composiciones capaces de reducir la actividad de la enzima hidroxilasa HIF, por ello incrementando la estabilidad y/o actividad del factor inducible por hipoxia (HIF).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261672191P | 2012-07-16 | 2012-07-16 | |
PCT/US2013/050538 WO2014014834A1 (en) | 2012-07-16 | 2013-07-15 | Process for making isoquinoline compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015000505A MX2015000505A (es) | 2015-07-17 |
MX350922B true MX350922B (es) | 2017-09-25 |
Family
ID=48857024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015000505A MX350922B (es) | 2012-07-16 | 2013-07-15 | Proceso para elaborar compuestos de isoquinolina. |
Country Status (21)
Country | Link |
---|---|
US (2) | US9340511B2 (es) |
EP (2) | EP3219706A1 (es) |
JP (1) | JP6196671B2 (es) |
KR (1) | KR102145272B1 (es) |
CN (2) | CN106083719B (es) |
AU (1) | AU2013290437B2 (es) |
BR (1) | BR112015001106B1 (es) |
CA (1) | CA2879238C (es) |
DK (1) | DK2872487T3 (es) |
ES (1) | ES2631655T3 (es) |
HU (2) | HUE034409T2 (es) |
IL (1) | IL236625B (es) |
IN (1) | IN2015KN00265A (es) |
MX (1) | MX350922B (es) |
MY (1) | MY171483A (es) |
NZ (1) | NZ704660A (es) |
PL (1) | PL2872487T3 (es) |
PT (1) | PT2872487T (es) |
SG (1) | SG11201500234YA (es) |
WO (1) | WO2014014834A1 (es) |
ZA (1) | ZA201500664B (es) |
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DK1644336T3 (da) | 2003-06-06 | 2011-05-09 | Fibrogen Inc | Nitrogenholdige heteroarylforbindelser og deres anvendelse til forøgelse af endogent erythropoietin |
WO2010056767A1 (en) | 2008-11-14 | 2010-05-20 | Fibrogen, Inc. | Thiochromene derivatives as hip hydroxylase inhibitors |
WO2014014834A1 (en) | 2012-07-16 | 2014-01-23 | Fibrogen, Inc. | Process for making isoquinoline compounds |
EP3470397B1 (en) * | 2012-07-16 | 2021-12-29 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
ES2786924T3 (es) | 2013-06-06 | 2020-10-14 | Fibrogen Inc | Formulaciones farmacéuticas que comprenden un inhibidor de hidroxilasa del HIF |
CN103694172A (zh) * | 2013-12-26 | 2014-04-02 | 辽宁亿灵科创生物医药科技有限公司 | 含氮杂芳基化合物的衍生物 |
ES2898476T3 (es) | 2014-09-02 | 2022-03-07 | Sunshine Lake Pharma Co Ltd | Compuesto de quinolona y uso del mismo |
WO2016045125A1 (en) * | 2014-09-28 | 2016-03-31 | Merck Sharp & Dohme Corp. | Inhibitors of hif prolyl hydroxylase |
CN104447547B (zh) * | 2014-11-10 | 2017-04-19 | 苏州康润医药有限公司 | 4‑氨基异喹啉‑8‑甲酸甲酯的合成方法 |
CN106146490B (zh) * | 2015-03-27 | 2018-10-23 | 沈阳三生制药有限责任公司 | 被芳氧基或杂芳氧基取代的5-羟基-1,7-萘啶化合物、其制备方法及其制药用途 |
CN104892509B (zh) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
CN106187888A (zh) * | 2016-07-18 | 2016-12-07 | 江苏德源药业股份有限公司 | Fg‑4592单晶及其制备方法 |
CN106478503A (zh) * | 2016-09-29 | 2017-03-08 | 上海勋和医药科技有限公司 | Roxadustat中间体的制备方法 |
CZ2016627A3 (cs) | 2016-10-07 | 2018-04-18 | Zentiva, K.S. | Způsob přípravy (7-fenoxy-4-hydroxy-1-methylisochinolin-3-karbonyl)glycinu (roxadustatu) a jeho intermediátů založený na souběžném otevírání oxazolového kruhu, štěpení etheru a tvorbě iminu |
CN107954931B (zh) * | 2016-10-17 | 2021-06-22 | 上海医药集团青岛国风药业股份有限公司 | 一种诺得司他的制备方法 |
EP3573615A4 (en) * | 2017-01-28 | 2020-10-28 | Kingchem Life Science LLC | PROCESS FOR THE PREPARATION OF 5-PHENOXY-1 (3H) ISOBENZOFURANONE |
CN111566090A (zh) * | 2017-12-01 | 2020-08-21 | 雷迪博士实验室有限公司 | 罗沙司他及其中间体的制备方法 |
CN109956870A (zh) | 2017-12-14 | 2019-07-02 | 南京卡文迪许生物工程技术有限公司 | 一种罗沙司他的合成方法及其中间体化合物 |
CN110218184B (zh) * | 2018-03-01 | 2022-09-27 | 广东东阳光药业有限公司 | 诺德司他共晶及其制备方法 |
WO2019174631A1 (zh) * | 2018-03-16 | 2019-09-19 | 上海医药集团股份有限公司 | 一种诺得司他的制备方法 |
CN110526813B (zh) * | 2018-05-24 | 2022-06-28 | 杭州科巢生物科技有限公司 | 异喹啉化合物的制备方法及其中间体 |
CN111978226B (zh) | 2018-06-05 | 2022-03-04 | 沈阳化工大学 | 一种三氟乙基硫醚(亚砜)取代苯类化合物及其用途 |
BR112021008741A2 (pt) | 2018-11-09 | 2021-08-10 | Vivace Therapeutics, Inc. | compostos bicíclicos |
CN109776415B (zh) * | 2019-03-07 | 2020-11-17 | 福建南方制药股份有限公司 | 一种Roxadustat中间体的制备方法 |
KR20220016456A (ko) | 2019-04-16 | 2022-02-09 | 비바체 테라퓨틱스, 인크. | 바이사이클릭 화합물 |
RU2709493C1 (ru) * | 2019-08-01 | 2019-12-18 | Марат Феликсович Фазылов | Способ получения роксадустата |
EP4010318A1 (en) | 2019-08-07 | 2022-06-15 | Teva Pharmaceuticals International GmbH | Processes for the preparation of roxadustat and intermediates thereof |
CN112441975B (zh) * | 2019-09-03 | 2023-10-31 | 西藏嘉信景天药业有限公司 | 一种罗沙司他重要中间体的制备方法 |
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WO2021073623A1 (zh) * | 2019-10-18 | 2021-04-22 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
CN112679430B (zh) * | 2019-10-18 | 2023-05-05 | 上海迪赛诺化学制药有限公司 | 一种制备异喹啉酮类化合物的方法 |
CN113444042A (zh) * | 2020-03-27 | 2021-09-28 | 南京海润医药有限公司 | 一种罗沙司他的制备方法 |
WO2021214785A1 (en) | 2020-04-21 | 2021-10-28 | Mylan Laboratories Limited | Improved process for the preparation of roxadustat |
CN111533691A (zh) * | 2020-06-08 | 2020-08-14 | 重庆三圣实业股份有限公司 | 一种罗沙司他的制备方法 |
EP4169906A4 (en) | 2020-06-19 | 2023-09-27 | Jumpcan (Shanghai) Medical Technology Co., Ltd | PROCESS FOR SYNTHESIS OF ROXADUSTAT AND ITS INTERMEDIATE AND ASSOCIATED INTERMEDIATE |
CN112409258A (zh) * | 2020-11-20 | 2021-02-26 | 杭州科巢生物科技有限公司 | 一种罗沙司他的制备方法 |
CN114644589A (zh) * | 2020-12-17 | 2022-06-21 | 鲁南制药集团股份有限公司 | 一种化合物n-[(4-羟基--1-甲基-3-异喹啉基)羰基]-甘氨酸的制备方法 |
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CN115124467A (zh) * | 2022-07-11 | 2022-09-30 | 天津力生制药股份有限公司 | 一种罗沙司他关键中间体的制备方法 |
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2013
- 2013-07-15 WO PCT/US2013/050538 patent/WO2014014834A1/en active Application Filing
- 2013-07-15 EP EP17155678.0A patent/EP3219706A1/en not_active Withdrawn
- 2013-07-15 CN CN201610421229.1A patent/CN106083719B/zh active Active
- 2013-07-15 EP EP13740184.0A patent/EP2872487B1/en active Active
- 2013-07-15 JP JP2015523159A patent/JP6196671B2/ja active Active
- 2013-07-15 PT PT137401840T patent/PT2872487T/pt unknown
- 2013-07-15 NZ NZ704660A patent/NZ704660A/en unknown
- 2013-07-15 MY MYPI2015000128A patent/MY171483A/en unknown
- 2013-07-15 CN CN201310302822.0A patent/CN103435546B/zh active Active
- 2013-07-15 HU HUE13740184A patent/HUE034409T2/en unknown
- 2013-07-15 US US14/414,879 patent/US9340511B2/en active Active
- 2013-07-15 SG SG11201500234YA patent/SG11201500234YA/en unknown
- 2013-07-15 AU AU2013290437A patent/AU2013290437B2/en active Active
- 2013-07-15 MX MX2015000505A patent/MX350922B/es active IP Right Grant
- 2013-07-15 CA CA2879238A patent/CA2879238C/en active Active
- 2013-07-15 PL PL13740184T patent/PL2872487T3/pl unknown
- 2013-07-15 DK DK13740184.0T patent/DK2872487T3/en active
- 2013-07-15 BR BR112015001106-3A patent/BR112015001106B1/pt active IP Right Grant
- 2013-07-15 ES ES13740184.0T patent/ES2631655T3/es active Active
- 2013-07-15 KR KR1020157003197A patent/KR102145272B1/ko active Protection Beyond IP Right Term
- 2013-07-15 IN IN265KON2015 patent/IN2015KN00265A/en unknown
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2015
- 2015-01-11 IL IL236625A patent/IL236625B/en active IP Right Grant
- 2015-01-29 ZA ZA2015/00664A patent/ZA201500664B/en unknown
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2016
- 2016-03-17 US US15/073,251 patent/US9708269B2/en active Active
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2022
- 2022-06-16 HU HUS2200030C patent/HUS2200030I1/hu unknown
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