MX2022008085A - Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t. - Google Patents
Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t.Info
- Publication number
- MX2022008085A MX2022008085A MX2022008085A MX2022008085A MX2022008085A MX 2022008085 A MX2022008085 A MX 2022008085A MX 2022008085 A MX2022008085 A MX 2022008085A MX 2022008085 A MX2022008085 A MX 2022008085A MX 2022008085 A MX2022008085 A MX 2022008085A
- Authority
- MX
- Mexico
- Prior art keywords
- cereblon
- cell function
- small molecules
- molecules against
- enhance effector
- Prior art date
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Abstract
Se describen moléculas pequeñas contra cereblon para mejorar la función efectora de linfocitos T. También se describen métodos para obtener dichas moléculas y métodos para usarlas en el tratamiento de varios estados de la enfermedad.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US201662309246P | 2016-03-16 | 2016-03-16 | |
US201662395757P | 2016-09-16 | 2016-09-16 | |
US201762454028P | 2017-02-02 | 2017-02-02 | |
PCT/US2017/022711 WO2017161119A1 (en) | 2016-03-16 | 2017-03-16 | Small molecules against cereblon to enhance effector t cell function |
Publications (1)
Publication Number | Publication Date |
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MX2022008085A true MX2022008085A (es) | 2022-07-11 |
Family
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MX2018011216A MX2018011216A (es) | 2016-03-16 | 2017-03-16 | Moléculas pequeñas contra cereblon para mejorar la función efectora de los linfocitos t. |
MX2022008085A MX2022008085A (es) | 2016-03-16 | 2017-03-16 | Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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MX2018011216A MX2018011216A (es) | 2016-03-16 | 2017-03-16 | Moléculas pequeñas contra cereblon para mejorar la función efectora de los linfocitos t. |
Country Status (10)
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US (2) | US11395820B2 (es) |
EP (1) | EP3429996A4 (es) |
JP (2) | JP7264642B2 (es) |
KR (1) | KR102520814B1 (es) |
CN (1) | CN109153644B (es) |
AU (2) | AU2017232906B2 (es) |
BR (1) | BR112018068906A2 (es) |
CA (1) | CA3017740A1 (es) |
MX (2) | MX2018011216A (es) |
WO (1) | WO2017161119A1 (es) |
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US20160058872A1 (en) * | 2014-04-14 | 2016-03-03 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
CN107257800B (zh) | 2014-12-23 | 2020-06-30 | 达纳-法伯癌症研究所股份有限公司 | 通过双功能分子诱导靶蛋白降解的方法 |
US20180185502A1 (en) | 2015-06-23 | 2018-07-05 | Ohio State Innovation Foundation | Immobilization of biomolecules by self-assembled nanostructures |
WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
RU2018120330A (ru) | 2015-11-02 | 2019-12-04 | Йейл Юниверсити | Химерные соединения, осуществляющие нацеливание для протеолиза, и способы их получения и применения |
EP3544975B1 (en) | 2016-11-22 | 2022-01-05 | Dana-Farber Cancer Institute, Inc. | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and use |
KR102129367B1 (ko) | 2017-10-20 | 2020-07-03 | 한국화학연구원 | 세레브론 단백질의 분해 유도 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
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2017
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- 2017-03-16 BR BR112018068906A patent/BR112018068906A2/pt not_active Application Discontinuation
- 2017-03-16 CA CA3017740A patent/CA3017740A1/en active Pending
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CN109153644A (zh) | 2019-01-04 |
US11395820B2 (en) | 2022-07-26 |
EP3429996A4 (en) | 2020-02-12 |
CA3017740A1 (en) | 2017-09-21 |
US20210177825A1 (en) | 2021-06-17 |
BR112018068906A2 (pt) | 2019-01-22 |
JP2019512497A (ja) | 2019-05-16 |
AU2022203645A1 (en) | 2022-06-16 |
US20230226035A1 (en) | 2023-07-20 |
JP7264642B2 (ja) | 2023-04-25 |
KR20180125521A (ko) | 2018-11-23 |
AU2017232906A1 (en) | 2018-09-27 |
WO2017161119A1 (en) | 2017-09-21 |
JP2022105141A (ja) | 2022-07-12 |
MX2018011216A (es) | 2019-08-29 |
EP3429996A1 (en) | 2019-01-23 |
KR102520814B1 (ko) | 2023-04-11 |
AU2017232906B2 (en) | 2022-03-31 |
CN109153644B (zh) | 2022-10-21 |
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