IT1184164B - Triptidi ad azione ipotensiva e procedimento per la loro sintesi - Google Patents
Triptidi ad azione ipotensiva e procedimento per la loro sintesiInfo
- Publication number
- IT1184164B IT1184164B IT19961/85A IT1996185A IT1184164B IT 1184164 B IT1184164 B IT 1184164B IT 19961/85 A IT19961/85 A IT 19961/85A IT 1996185 A IT1996185 A IT 1996185A IT 1184164 B IT1184164 B IT 1184164B
- Authority
- IT
- Italy
- Prior art keywords
- triptides
- hypothensive
- synthesis
- procedure
- action
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19961/85A IT1184164B (it) | 1985-03-19 | 1985-03-19 | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
EP86200345A EP0199379B1 (en) | 1985-03-19 | 1986-03-07 | Pharmacologically active tripeptides and process for their synthesis |
DE8686200345T DE3674623D1 (de) | 1985-03-19 | 1986-03-07 | Tripeptide mit pharmazeutischer wirksamkeit und verfahren zu ihrer herstellung. |
US06/838,120 US4748155A (en) | 1985-03-19 | 1986-03-10 | Pharmacologically active tripeptides and process for their synthesis |
JP61059653A JPH0688968B2 (ja) | 1985-03-19 | 1986-03-19 | トリペプチド及び医薬組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19961/85A IT1184164B (it) | 1985-03-19 | 1985-03-19 | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8519961A0 IT8519961A0 (it) | 1985-03-19 |
IT1184164B true IT1184164B (it) | 1987-10-22 |
Family
ID=11162667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT19961/85A IT1184164B (it) | 1985-03-19 | 1985-03-19 | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
Country Status (5)
Country | Link |
---|---|
US (1) | US4748155A (it) |
EP (1) | EP0199379B1 (it) |
JP (1) | JPH0688968B2 (it) |
DE (1) | DE3674623D1 (it) |
IT (1) | IT1184164B (it) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5213974A (en) * | 1986-05-20 | 1993-05-25 | Sankyo Company, Limited | Fermentation process for preparing antibiotics mureidomycins A, B, C and D |
ES2060587T3 (es) * | 1986-05-20 | 1994-12-01 | Sankyo Co | Un procedimiento para producir los compuestos llamados mureidomicina a,b,c o d y sus sales y esteres. |
DE3854205T2 (de) * | 1987-11-20 | 1996-04-04 | Sankyo Co | Zwischenprodukte der Mureidomycin-Gruppe, ihre Herstellung und Verwendung. |
US5049548A (en) * | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
FR2649110B1 (fr) * | 1989-06-29 | 1994-10-21 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
IT1261646B (it) * | 1992-08-04 | 1996-05-28 | Ellem Ind Farmaceutica | Derivati peptidici ad attivita' citostimolante e citoprotettiva |
NZ255256A (en) | 1992-08-27 | 1997-02-24 | Deakin Res Ltd | Synthetic peptide antigen analogues with retro, inverso or retro-inverso modification, their use and antibodies against them |
AU2005239771B2 (en) * | 2004-05-06 | 2011-03-10 | Yara Cury | Analgesic peptides derived from the venom of crotalus durissus terrificuss snakes |
CN109153644B (zh) | 2016-03-16 | 2022-10-21 | H·李·莫菲特癌症中心研究有限公司 | 用以增强效应t细胞功能的针对cereblon的小分子 |
WO2020014489A2 (en) | 2018-07-11 | 2020-01-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876624A (en) * | 1973-10-29 | 1975-04-08 | American Home Prod | P-glu' his' n' ala' nh' 2 'and intermediates |
IT1212508B (it) * | 1981-12-22 | 1989-11-22 | Anic Spa | Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori |
IT1164225B (it) * | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
IT1172391B (it) * | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
IT1206339B (it) * | 1984-01-13 | 1989-04-14 | Anic Spa | Analoghi retro-invertiti esapeptidici c-terminali della sostanza p. |
-
1985
- 1985-03-19 IT IT19961/85A patent/IT1184164B/it active
-
1986
- 1986-03-07 EP EP86200345A patent/EP0199379B1/en not_active Expired - Lifetime
- 1986-03-07 DE DE8686200345T patent/DE3674623D1/de not_active Expired - Lifetime
- 1986-03-10 US US06/838,120 patent/US4748155A/en not_active Expired - Fee Related
- 1986-03-19 JP JP61059653A patent/JPH0688968B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0688968B2 (ja) | 1994-11-09 |
EP0199379A3 (en) | 1987-05-13 |
IT8519961A0 (it) | 1985-03-19 |
JPS61233665A (ja) | 1986-10-17 |
EP0199379A2 (en) | 1986-10-29 |
US4748155A (en) | 1988-05-31 |
DE3674623D1 (de) | 1990-11-08 |
EP0199379B1 (en) | 1990-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950330 |