MX2021008434A - Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn. - Google Patents

Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn.

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Publication number
MX2021008434A
MX2021008434A MX2021008434A MX2021008434A MX2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A
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Mexico
Prior art keywords
cancer
rna
methods
individual
binding antagonist
Prior art date
Application number
MX2021008434A
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English (en)
Inventor
Lars Mueller
Gregg Daniel Fine
Original Assignee
Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2021008434A publication Critical patent/MX2021008434A/es

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    • A61K39/0011—Cancer antigens
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    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure

Abstract

La presente divulgación proporciona métodos, usos y kits para tratar el cáncer en un individuo. Los métodos comprenden administrar al individuo un antagonista de unión al eje de PD-1 (tal como un anticuerpo anti-PD-1 o anti-PDL1) y una vacuna de ARN (por ejemplo, una vacuna contra el cáncer personalizada que comprende uno o más polinucleótidos que codifican uno o más neoepítopos resultantes de mutaciones somáticas específicas de cáncer presentes en una muestra tumoral obtenida del individuo). En la presente se proporcionan además moléculas de ARN (por ejemplo, una vacuna contra el cáncer de ARN personalizada que comprende uno o más polinucleótidos que codifican uno o más neoepítopos resultantes de mutaciones somáticas específicas de cáncer presentes en una muestra tumoral obtenida del individuo), así como moléculas de ADN y métodos útiles para la producción o uso de vacunas de ARN.
MX2021008434A 2019-01-14 2020-01-13 Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn. MX2021008434A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962792387P 2019-01-14 2019-01-14
US201962795476P 2019-01-22 2019-01-22
US201962887410P 2019-08-15 2019-08-15
PCT/US2020/013353 WO2020150152A1 (en) 2019-01-14 2020-01-13 Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine

Publications (1)

Publication Number Publication Date
MX2021008434A true MX2021008434A (es) 2021-09-23

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MX2021008434A MX2021008434A (es) 2019-01-14 2020-01-13 Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn.

Country Status (11)

Country Link
US (1) US20210346485A1 (es)
EP (1) EP3911678A1 (es)
JP (1) JP2022518399A (es)
KR (1) KR20210116525A (es)
CN (2) CN113710702A (es)
AU (1) AU2020208193A1 (es)
CA (1) CA3124837A1 (es)
IL (1) IL284583A (es)
MX (1) MX2021008434A (es)
TW (1) TW202043272A (es)
WO (1) WO2020150152A1 (es)

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TW202043256A (zh) 2019-01-10 2020-12-01 美商健生生物科技公司 ***新抗原及其用途
TW202142257A (zh) * 2020-01-31 2021-11-16 美商建南德克公司 用ｐｄ－１軸結合拮抗劑及ｒｎａ疫苗誘導新抗原決定基特異性ｔ細胞之方法
CN113521268A (zh) 2020-04-22 2021-10-22 生物技术Rna制药有限公司 冠状病毒疫苗
TW202245808A (zh) * 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
CN112501201A (zh) * 2021-02-07 2021-03-16 无锡市人民医院 一种用于治疗非小细胞肺癌的rna疫苗及其构建方法
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