MX2019007189A - Compuestos de amino-triazolopiridina y su uso en el trataniento del cancer. - Google Patents

Compuestos de amino-triazolopiridina y su uso en el trataniento del cancer.

Info

Publication number
MX2019007189A
MX2019007189A MX2019007189A MX2019007189A MX2019007189A MX 2019007189 A MX2019007189 A MX 2019007189A MX 2019007189 A MX2019007189 A MX 2019007189A MX 2019007189 A MX2019007189 A MX 2019007189A MX 2019007189 A MX2019007189 A MX 2019007189A
Authority
MX
Mexico
Prior art keywords
compounds
salts
amino
treating cancer
triazolopyridine compounds
Prior art date
Application number
MX2019007189A
Other languages
English (en)
Inventor
Raymond Verschoyle Finlay Maurice
Woolf Goldberg Frederick
Kuan Tsuei Ting Attilla
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2019007189A publication Critical patent/MX2019007189A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La memoria descriptiva se refiere en general a compuestos de Fórmula (I): (ver fórmula) y sales farmacéuticamente aceptables de los mismos, donde R1 y R2 tienen cualquiera de los significados definidos en el presente documento. La memoria descriptiva también se refiere al uso de dichos compuestos y sales de los mismos para tratar o prevenir una enfermedad mediada por PC-ADN, incluyendo el cáncer. La memoria descriptiva se refiere además a composiciones farmacéuticas que comprenden dichos compuestos y sales; kits que comprenden tales compuestos y sales; métodos de fabricación de dichos compuestos y sales; intermedios útiles en la fabricación de dichos compuestos y sales; y a los métodos para tratar una enfermedad mediada por PC-ADN, incluyendo el cáncer, usando dichos compuestos y sales.
MX2019007189A 2016-12-20 2017-12-19 Compuestos de amino-triazolopiridina y su uso en el trataniento del cancer. MX2019007189A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662436619P 2016-12-20 2016-12-20
PCT/EP2017/083625 WO2018114999A1 (en) 2016-12-20 2017-12-19 Amino-triazolopyridine compounds and their use in treating cancer

Publications (1)

Publication Number Publication Date
MX2019007189A true MX2019007189A (es) 2019-10-09

Family

ID=60937727

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007189A MX2019007189A (es) 2016-12-20 2017-12-19 Compuestos de amino-triazolopiridina y su uso en el trataniento del cancer.

Country Status (38)

Country Link
US (4) US10407446B2 (es)
EP (1) EP3558997B1 (es)
JP (1) JP6883653B2 (es)
KR (1) KR102220971B1 (es)
CN (1) CN110177791B (es)
AR (1) AR110400A1 (es)
AU (1) AU2017384388B2 (es)
BR (1) BR112019012217B1 (es)
CA (1) CA3046339C (es)
CL (1) CL2019001714A1 (es)
CO (1) CO2019007810A2 (es)
CR (1) CR20190301A (es)
CY (1) CY1124239T1 (es)
DK (1) DK3558997T3 (es)
DO (1) DOP2019000168A (es)
EA (1) EA037745B1 (es)
EC (1) ECSP19044159A (es)
ES (1) ES2867274T3 (es)
HR (1) HRP20210548T1 (es)
HU (1) HUE054548T2 (es)
IL (1) IL267158B (es)
JO (1) JOP20190151B1 (es)
LT (1) LT3558997T (es)
MA (1) MA47079B1 (es)
MX (1) MX2019007189A (es)
MY (1) MY183036A (es)
NI (1) NI201900062A (es)
NZ (1) NZ755222A (es)
PE (1) PE20191474A1 (es)
PH (1) PH12019501350A1 (es)
PL (1) PL3558997T3 (es)
PT (1) PT3558997T (es)
RS (1) RS61701B1 (es)
SI (1) SI3558997T1 (es)
TW (1) TWI776835B (es)
UA (1) UA123032C2 (es)
WO (1) WO2018114999A1 (es)
ZA (1) ZA201904695B (es)

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ZA201904695B (en) 2021-05-26
US20220041625A1 (en) 2022-02-10
AR110400A1 (es) 2019-03-27
EP3558997A1 (en) 2019-10-30
NI201900062A (es) 2020-07-22
CL2019001714A1 (es) 2019-09-06
KR20190092573A (ko) 2019-08-07
MA47079A (fr) 2019-10-30
US11136340B2 (en) 2021-10-05
DK3558997T3 (da) 2021-04-19
CN110177791A (zh) 2019-08-27
PL3558997T3 (pl) 2021-07-19
US20200048281A1 (en) 2020-02-13
PT3558997T (pt) 2021-04-13
IL267158B (en) 2020-10-29
CO2019007810A2 (es) 2019-10-09
CA3046339A1 (en) 2018-06-28
EA201991399A1 (ru) 2020-01-22
JOP20190151A1 (ar) 2019-06-20
JP6883653B2 (ja) 2021-06-09
BR112019012217A2 (pt) 2019-11-12
CY1124239T1 (el) 2022-07-22
US20180194782A1 (en) 2018-07-12
MA47079B1 (fr) 2021-05-31
NZ755222A (en) 2022-07-01
AU2017384388B2 (en) 2020-09-17
JOP20190151B1 (ar) 2023-09-17
LT3558997T (lt) 2021-04-26
JP2020504107A (ja) 2020-02-06
UA123032C2 (uk) 2021-02-03
SI3558997T1 (sl) 2021-07-30
HRP20210548T1 (hr) 2021-05-14
CA3046339C (en) 2022-02-22
MY183036A (en) 2021-02-08
EP3558997B1 (en) 2021-01-27
HUE054548T2 (hu) 2021-09-28
ES2867274T3 (es) 2021-10-20
ECSP19044159A (es) 2019-06-30
US10407446B2 (en) 2019-09-10
DOP2019000168A (es) 2019-07-15
EA037745B1 (ru) 2021-05-18
TWI776835B (zh) 2022-09-11
AU2017384388A1 (en) 2019-07-25
US20240124492A1 (en) 2024-04-18
PE20191474A1 (es) 2019-10-16
RS61701B1 (sr) 2021-05-31
KR102220971B1 (ko) 2021-02-25
PH12019501350A1 (en) 2020-01-20
CN110177791B (zh) 2022-07-12
WO2018114999A1 (en) 2018-06-28
TW201837045A (zh) 2018-10-16
US11746118B2 (en) 2023-09-05
CR20190301A (es) 2019-09-04
BR112019012217B1 (pt) 2021-08-10
IL267158A (en) 2019-08-29

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