MX2016014235A - Biosintesis microbiana de ergotioneina. - Google Patents

Biosintesis microbiana de ergotioneina.

Info

Publication number
MX2016014235A
MX2016014235A MX2016014235A MX2016014235A MX2016014235A MX 2016014235 A MX2016014235 A MX 2016014235A MX 2016014235 A MX2016014235 A MX 2016014235A MX 2016014235 A MX2016014235 A MX 2016014235A MX 2016014235 A MX2016014235 A MX 2016014235A
Authority
MX
Mexico
Prior art keywords
methods
microbial
biosynthesis
ergothioneine biosynthesis
present disclosure
Prior art date
Application number
MX2016014235A
Other languages
English (en)
Inventor
Hui Chen
YU Oliver
Han Jixiang
Original Assignee
Conagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conagen Inc filed Critical Conagen Inc
Publication of MX2016014235A publication Critical patent/MX2016014235A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids

Abstract

Se describen métodos para la biosíntesis de ergotioneína; de manera más particular, la presente descripción se relaciona con métodos para biosíntesis microbiana de ergotioneína; la presente descripción se relaciona de manera general con célula hospederas manipuladas y métodos para producir ergotioneína; más particularmente, la presente descripción se relaciona con una célula hospedera manipulada y métodos para biosíntesis microbiana de ergotioneína utilizando la célula hospedera manipulada.
MX2016014235A 2014-04-29 2015-04-28 Biosintesis microbiana de ergotioneina. MX2016014235A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461985778P 2014-04-29 2014-04-29
PCT/US2015/027977 WO2015168112A1 (en) 2014-04-29 2015-04-28 Microbial ergothioneine biosynthesis

Publications (1)

Publication Number Publication Date
MX2016014235A true MX2016014235A (es) 2017-02-14

Family

ID=54359235

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014235A MX2016014235A (es) 2014-04-29 2015-04-28 Biosintesis microbiana de ergotioneina.

Country Status (6)

Country Link
US (2) US10544437B2 (es)
EP (1) EP3137611B1 (es)
CN (1) CN106661585B (es)
CA (1) CA2975238C (es)
MX (1) MX2016014235A (es)
WO (1) WO2015168112A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2975238C (en) 2014-04-29 2021-05-11 Conagen Inc. Microbial ergothioneine biosynthesis
WO2017150304A1 (ja) * 2016-02-29 2017-09-08 長瀬産業株式会社 エルゴチオネインの発酵生産
CN112004936A (zh) * 2018-02-23 2020-11-27 长濑产业株式会社 麦角硫因生产方法
BR112021021777A2 (pt) * 2019-04-30 2022-02-08 Univ Danmarks Tekniske Métodos para a produção de ergotioneína
US20220281822A1 (en) 2019-07-10 2022-09-08 Kureha Corporation Plant growth regulator and method for promoting plant growth
CN110358719B (zh) * 2019-07-23 2021-05-04 江南大学 一种发酵合成麦角硫因的工程菌株及其构建方法
CN110607286B (zh) * 2019-08-21 2021-02-19 华南农业大学 灰树花麦角硫因基因Gfegt1和Gfegt2在合成麦角硫因中的应用
CN110551697B (zh) * 2019-08-26 2021-02-19 华南农业大学 侧耳类食用菌麦角硫因合成酶pegt1和pegt2在合成麦角硫因中的应用
US20230024648A1 (en) * 2019-11-27 2023-01-26 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Ean B Mutants and Their Uses
CN111004730A (zh) * 2019-12-30 2020-04-14 江苏瑞霆生物科技有限公司 一种生产麦角硫因的方法
JP7120588B2 (ja) * 2020-01-09 2022-08-17 株式会社クレハ 新規微生物およびエルゴチオネインの生産方法
CN112251392B (zh) * 2020-10-26 2022-09-09 天津科技大学 一种生产麦角硫因的基因工程菌株及其应用
EP4291182A1 (en) 2021-02-15 2023-12-20 Conagen Inc. Microbial ergothioneine biosynthesis
CN114262702B (zh) * 2021-12-31 2023-12-08 西南大学 麦角硫因合成基因在谷氨酸棒杆菌中重建麦角硫因代谢途径中的应用及其方法
CN114854659B (zh) * 2022-05-27 2024-03-26 深圳中科欣扬生物科技有限公司 一种麦角硫因生产工艺及其应用
CN114854660B (zh) * 2022-05-27 2024-03-26 深圳中科欣扬生物科技有限公司 一种高产麦角硫因的基因工程菌
CN116970546B (zh) * 2023-09-22 2023-12-26 江苏省中国科学院植物研究所 一种合成麦角硫因的工程菌株及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (fr) 1993-06-28 1995-10-13 Bioxytech Nouveau procédé de préparation de l'ergothionéine.
US6326034B1 (en) 1999-12-22 2001-12-04 Natural Compounds Ltd Natural extracted and synthetic antioxidant compositions
CA2551537A1 (en) * 2006-07-04 2008-01-04 Institut Pasteur Method for preparing recombinant mycobacterial polypeptides in yeast and their use in diagnosis of mycobacterial related diseases
US7767826B2 (en) 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine
FR2950889B1 (fr) 2009-10-06 2011-11-18 Tetrahedron Procede de synthese de l'ergothioneine et analogues
CN103184246B (zh) * 2011-12-31 2017-03-22 中国科学院天津工业生物技术研究所 麦角硫因的生物合成制备方法
CN103734022B (zh) * 2012-10-16 2017-09-05 中国科学院天津工业生物技术研究所 生产麦角硫因的菌株及制备麦角硫因的方法
US10167490B2 (en) * 2012-12-21 2019-01-01 Ergo Health Llc Ergothioneine production through metabolic engineering
CA2975238C (en) 2014-04-29 2021-05-11 Conagen Inc. Microbial ergothioneine biosynthesis

Also Published As

Publication number Publication date
US20170051325A1 (en) 2017-02-23
EP3137611B1 (en) 2021-02-24
CN106661585B (zh) 2021-04-09
US10544437B2 (en) 2020-01-28
US20200224232A1 (en) 2020-07-16
EP3137611A1 (en) 2017-03-08
EP3137611A4 (en) 2018-03-07
CN106661585A (zh) 2017-05-10
WO2015168112A1 (en) 2015-11-05
CA2975238A1 (en) 2015-11-05
CA2975238C (en) 2021-05-11

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