MX2016012446A - Derivados de quinoxalina utiles como amortiguadaores de receptor del factor de crecimiento de fibroblastos (fgfr) cinasa. - Google Patents
Derivados de quinoxalina utiles como amortiguadaores de receptor del factor de crecimiento de fibroblastos (fgfr) cinasa.Info
- Publication number
- MX2016012446A MX2016012446A MX2016012446A MX2016012446A MX2016012446A MX 2016012446 A MX2016012446 A MX 2016012446A MX 2016012446 A MX2016012446 A MX 2016012446A MX 2016012446 A MX2016012446 A MX 2016012446A MX 2016012446 A MX2016012446 A MX 2016012446A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives useful
- quinoxaline derivatives
- fgfr kinase
- kinase modulators
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se relaciona con nuevos compuestos derivados de quinoxalina, con composiciones farmacéuticas que comprenden los compuestos, con procesos para la preparación de los compuestos y con el uso de los compuestos en el tratamiento de enfermedades, por ejemplo, cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14161820 | 2014-03-26 | ||
PCT/EP2015/056507 WO2015144803A1 (en) | 2014-03-26 | 2015-03-26 | Quinoxaline derivatives useful as fgfr kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016012446A true MX2016012446A (es) | 2017-01-06 |
Family
ID=50389854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016012446A MX2016012446A (es) | 2014-03-26 | 2015-03-26 | Derivados de quinoxalina utiles como amortiguadaores de receptor del factor de crecimiento de fibroblastos (fgfr) cinasa. |
Country Status (37)
Country | Link |
---|---|
US (2) | US9902714B2 (es) |
EP (1) | EP3122742B1 (es) |
JP (1) | JP6625551B2 (es) |
KR (1) | KR102469506B1 (es) |
CN (1) | CN106459010B (es) |
AP (1) | AP2016009536A0 (es) |
AR (1) | AR099854A1 (es) |
AU (1) | AU2015238300C1 (es) |
BR (1) | BR112016022060B1 (es) |
CA (1) | CA2943683A1 (es) |
CL (1) | CL2016002382A1 (es) |
CR (1) | CR20160501A (es) |
CY (1) | CY1120969T1 (es) |
DK (1) | DK3122742T3 (es) |
EA (1) | EA032145B1 (es) |
ES (1) | ES2702450T3 (es) |
HR (1) | HRP20182073T1 (es) |
HU (1) | HUE041738T2 (es) |
IL (1) | IL247658B (es) |
JO (1) | JO3512B1 (es) |
LT (1) | LT3122742T (es) |
MA (1) | MA39783B1 (es) |
MX (1) | MX2016012446A (es) |
MY (1) | MY194074A (es) |
NI (1) | NI201600144A (es) |
NZ (1) | NZ724907A (es) |
PH (1) | PH12016501898A1 (es) |
PL (1) | PL3122742T3 (es) |
PT (1) | PT3122742T (es) |
RS (1) | RS58088B1 (es) |
SG (1) | SG11201607961QA (es) |
SI (1) | SI3122742T1 (es) |
TR (1) | TR201819138T4 (es) |
TW (1) | TWI686391B (es) |
UA (1) | UA117958C2 (es) |
WO (1) | WO2015144803A1 (es) |
ZA (1) | ZA201606942B (es) |
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GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
PT2861566T (pt) | 2012-06-13 | 2017-02-08 | Hoffmann La Roche | Novos diazaspirocicloalcanos e azaspirocicloalcanos |
UA116547C2 (uk) | 2012-09-25 | 2018-04-10 | Ф. Хоффманн-Ля Рош Аг | Біциклічні похідні |
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KR102479693B1 (ko) | 2014-03-26 | 2022-12-22 | 아스텍스 테라퓨틱스 리미티드 | 조합물 |
UA119347C2 (uk) | 2014-03-26 | 2019-06-10 | Ф. Хоффманн-Ля Рош Аг | Конденсовані [1,4]діазепінові сполуки як інгібітори продукції аутотаксину (atх) та лізофосфатидилової кислоти (lpa) |
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