MX2015011677A - Inhibidores de leucotrieno a4 hidrolasa. - Google Patents
Inhibidores de leucotrieno a4 hidrolasa.Info
- Publication number
- MX2015011677A MX2015011677A MX2015011677A MX2015011677A MX2015011677A MX 2015011677 A MX2015011677 A MX 2015011677A MX 2015011677 A MX2015011677 A MX 2015011677A MX 2015011677 A MX2015011677 A MX 2015011677A MX 2015011677 A MX2015011677 A MX 2015011677A
- Authority
- MX
- Mexico
- Prior art keywords
- hydrolase
- leukotriene
- inhibitors
- methods
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Abstract
La presente invención se orienta hacia compuestos englobados por la formula (I), las composiciones farmacéuticas de los mismos, métodos para inhibir el LTA 4 hidrolasa, así como métodos para el tratamiento contra una enfermedad o trastorno que se mejore por medio de la inhibición de la actividad del LTA4-h. Ejemplos no limitantes de dichas enfermedades y condiciones incluyen las enfermedades y trastornos inflamatorios y autoinmunes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361781181P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/027097 WO2014152229A2 (en) | 2013-03-14 | 2014-03-14 | Inhibitors of leukotriene a4 hydrolase |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015011677A true MX2015011677A (es) | 2016-07-08 |
Family
ID=51581688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015011677A MX2015011677A (es) | 2013-03-14 | 2014-03-14 | Inhibidores de leucotrieno a4 hidrolasa. |
Country Status (10)
Country | Link |
---|---|
US (2) | US9856249B2 (es) |
EP (1) | EP2968264A4 (es) |
JP (1) | JP2016513681A (es) |
KR (1) | KR20150127245A (es) |
AU (2) | AU2014240042C1 (es) |
BR (1) | BR112015022226A2 (es) |
CA (1) | CA2906035A1 (es) |
MX (1) | MX2015011677A (es) |
RU (1) | RU2696559C2 (es) |
WO (1) | WO2014152229A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012139080A2 (en) | 2011-04-06 | 2012-10-11 | Board Of Regents Of The University Of Texas System | Lipid-based nanoparticles |
EP2756459B1 (en) | 2012-01-20 | 2020-12-09 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
CA2905340C (en) | 2013-03-12 | 2022-05-31 | Celtaxsys, Inc. | Low dose oral formulations of acebilustat |
EP2970309A4 (en) | 2013-03-14 | 2016-11-09 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
EP2968264A4 (en) | 2013-03-14 | 2016-11-02 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
KR20150131211A (ko) | 2013-03-14 | 2015-11-24 | 켈탁시스, 인코퍼레이티드 | 류코트라이엔 a4 가수분해효소의 저해제 |
US9744251B2 (en) * | 2014-10-08 | 2017-08-29 | Texas Children's Hospital | MRI imaging of amyloid plaque using liposomes |
TWI691486B (zh) * | 2016-01-29 | 2020-04-21 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
EP3551611A1 (en) | 2016-12-09 | 2019-10-16 | Celtaxsys Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase |
JP7145154B2 (ja) * | 2016-12-09 | 2022-09-30 | セルタクシー、エルエルシー | ロイコトリエンa4ヒドロラーゼの阻害剤 |
CA3102077A1 (en) | 2018-05-31 | 2019-12-05 | Sanjeev AHUJA | Method of reducing pulmonary exacerbations in respiratory disease patients |
BR112023002031A2 (pt) | 2020-08-14 | 2023-03-07 | Novartis Ag | Derivados de espiropiperidinila substituídos por heteroarila e usos farmacêuticos dos mesmos |
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-
2014
- 2014-03-14 EP EP14768642.2A patent/EP2968264A4/en not_active Withdrawn
- 2014-03-14 AU AU2014240042A patent/AU2014240042C1/en not_active Ceased
- 2014-03-14 WO PCT/US2014/027097 patent/WO2014152229A2/en active Application Filing
- 2014-03-14 CA CA2906035A patent/CA2906035A1/en not_active Abandoned
- 2014-03-14 MX MX2015011677A patent/MX2015011677A/es unknown
- 2014-03-14 BR BR112015022226A patent/BR112015022226A2/pt not_active Application Discontinuation
- 2014-03-14 KR KR1020157028771A patent/KR20150127245A/ko not_active Application Discontinuation
- 2014-03-14 JP JP2016502333A patent/JP2016513681A/ja active Pending
- 2014-03-14 RU RU2015137976A patent/RU2696559C2/ru not_active IP Right Cessation
-
2015
- 2015-09-10 US US14/849,810 patent/US9856249B2/en not_active Expired - Fee Related
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2017
- 2017-12-13 US US15/840,097 patent/US10501455B2/en active Active
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2019
- 2019-06-27 AU AU2019204579A patent/AU2019204579A1/en not_active Abandoned
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US20160068524A1 (en) | 2016-03-10 |
WO2014152229A3 (en) | 2014-12-04 |
CA2906035A1 (en) | 2014-09-25 |
WO2014152229A2 (en) | 2014-09-25 |
RU2015137976A (ru) | 2017-04-20 |
AU2014240042A1 (en) | 2015-10-01 |
US20180162854A1 (en) | 2018-06-14 |
BR112015022226A2 (pt) | 2017-07-18 |
RU2696559C2 (ru) | 2019-08-05 |
AU2014240042B2 (en) | 2019-03-28 |
AU2014240042C1 (en) | 2019-09-05 |
US10501455B2 (en) | 2019-12-10 |
AU2019204579A1 (en) | 2019-07-18 |
EP2968264A4 (en) | 2016-11-02 |
JP2016513681A (ja) | 2016-05-16 |
KR20150127245A (ko) | 2015-11-16 |
EP2968264A2 (en) | 2016-01-20 |
US9856249B2 (en) | 2018-01-02 |
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