AR023659A1 - Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos - Google Patents

Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos

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Publication number
AR023659A1
AR023659A1 ARP990104643A ARP990104643A AR023659A1 AR 023659 A1 AR023659 A1 AR 023659A1 AR P990104643 A ARP990104643 A AR P990104643A AR P990104643 A ARP990104643 A AR P990104643A AR 023659 A1 AR023659 A1 AR 023659A1
Authority
AR
Argentina
Prior art keywords
alkyl
inhibitor compound
hydrogen
prevention
treatment
Prior art date
Application number
ARP990104643A
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English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR023659A1 publication Critical patent/AR023659A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P11/06—Antiasthmatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/04—Antibacterial agents
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    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Un compuesto inhibidor de la p38, la que es una proteinquinasa implicada en proliferacion celular, muerte celular y respuesta a estímulos extracelulares.Más particularmente, la presente invencion se refiere a un compuesto inhibidor de p38,caracteriz ado por la formula (1) o tautomeros del mismo o salesfarmacéuticamente aceptables del mismo; en donde: HET es un heterociclo de 5-7 miembros con 1 a 4 átomos de N, S u O, heterociclo que está sustituido con 1 a 3grupos alquilo C1-4, decadena recta o ramificada, y está sustituido opcionalmente con halo, ciano, N(R)2, OR, CO2R, CON(R)2, y SO2N(R2)2; X es O o NR;n es 1 a 3; R es seleccionado de hidrogeno, alquilo C1-3, alquenilo C2-3 o alquinilo C2-3 fenilo o fenilo sustituido con 1a 3 sustituyen tes seleccionadosindependientemente de halo, metoxi, ciano, nitro, amino, hidroxi, metilo o etilo; R1 es seleccionado de hidrogeno, alquilo C1-3, OH, u O-(alquilo C1-3); R2 esseleccionado de hidrogeno, alquilo C1-3, o alquenilo C1-3;estando cada uno sustituido opcionalmente con -N(R)2, -OR, SR, -C(O)-N(R)2, --S(O2)-N(R)2, C(O)-OR,o R3 es seleccionado de sistemas de un anillo carbocíclico aromático de 5-6 miembros o heterocíclico. La invencion se refiere también a métodosparaproducir estos inhi bidores, a composiciones farmacéuticas que los comprenden y al uso de dichas composiciones en el tratamiento y la prevencion de variosestados patologicos.
ARP990104643A 1998-09-18 1999-09-15 Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos AR023659A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10101398P 1998-09-18 1998-09-18

Publications (1)

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AR023659A1 true AR023659A1 (es) 2002-09-04

Family

ID=22282668

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ARP990104643A AR023659A1 (es) 1998-09-18 1999-09-15 Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos

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US (2) US6635644B2 (es)
EP (1) EP1114051B1 (es)
JP (1) JP2002526501A (es)
AR (1) AR023659A1 (es)
AT (1) ATE236167T1 (es)
AU (1) AU761599B2 (es)
CA (1) CA2339253C (es)
DE (1) DE69906554T2 (es)
DK (1) DK1114051T3 (es)
ES (1) ES2192864T3 (es)
MY (1) MY117696A (es)
PT (1) PT1114051E (es)
WO (1) WO2000017204A1 (es)

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ATE236167T1 (de) 2003-04-15
DE69906554D1 (de) 2003-05-08
CA2339253C (en) 2009-04-07
US20040142927A1 (en) 2004-07-22
CA2339253A1 (en) 2000-03-30
ES2192864T3 (es) 2003-10-16
US20020010170A1 (en) 2002-01-24
EP1114051B1 (en) 2003-04-02
US6635644B2 (en) 2003-10-21
PT1114051E (pt) 2003-07-31
DE69906554T2 (de) 2004-07-01
WO2000017204A1 (en) 2000-03-30
US7169779B2 (en) 2007-01-30
MY117696A (en) 2004-07-31
DK1114051T3 (da) 2003-07-14
AU6152199A (en) 2000-04-10
EP1114051A1 (en) 2001-07-11
AU761599B2 (en) 2003-06-05
JP2002526501A (ja) 2002-08-20

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