PT1008588E - Derivados da 11,15-o-diaklquil-prostaglandina e processo de producao dos mesmos e farmaco que os contem como ingrediente activo - Google Patents
Derivados da 11,15-o-diaklquil-prostaglandina e processo de producao dos mesmos e farmaco que os contem como ingrediente activoInfo
- Publication number
- PT1008588E PT1008588E PT98901576T PT98901576T PT1008588E PT 1008588 E PT1008588 E PT 1008588E PT 98901576 T PT98901576 T PT 98901576T PT 98901576 T PT98901576 T PT 98901576T PT 1008588 E PT1008588 E PT 1008588E
- Authority
- PT
- Portugal
- Prior art keywords
- active ingredient
- diaklquil
- pharmacy
- contain
- same
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 101150053131 PTGER3 gene Proteins 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 108010088540 Prostaglandin E receptors Proteins 0.000 abstract 1
- 102000008866 Prostaglandin E receptors Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical class CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4157197 | 1997-02-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1008588E true PT1008588E (pt) | 2003-09-30 |
Family
ID=12612138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98901576T PT1008588E (pt) | 1997-02-10 | 1998-02-10 | Derivados da 11,15-o-diaklquil-prostaglandina e processo de producao dos mesmos e farmaco que os contem como ingrediente activo |
Country Status (10)
Country | Link |
---|---|
US (1) | US6288119B1 (pt) |
EP (1) | EP1008588B1 (pt) |
JP (1) | JP4044967B2 (pt) |
KR (1) | KR20000070903A (pt) |
AT (1) | ATE237587T1 (pt) |
DE (1) | DE69813571T2 (pt) |
DK (1) | DK1008588T3 (pt) |
ES (1) | ES2196527T3 (pt) |
PT (1) | PT1008588E (pt) |
WO (1) | WO1998034916A1 (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL350917A1 (en) | 1999-03-05 | 2003-02-10 | Procter & Gamble | C16 unsaturated fp-selective prostaglandins analogs |
US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
JP4497320B2 (ja) | 2002-10-10 | 2010-07-07 | 小野薬品工業株式会社 | 内因性修復因子産生促進剤 |
US20060128810A1 (en) * | 2002-10-10 | 2006-06-15 | Kyoto University | Remedies for allergic diseases |
WO2004074842A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep3 (prostaglandin e2 ep3) |
EP1609480A1 (en) * | 2003-04-03 | 2005-12-28 | Ono Pharmaceutical Co., Ltd. | Remedy for spinal canal stenosis |
JP4666257B2 (ja) * | 2003-07-25 | 2011-04-06 | 小野薬品工業株式会社 | 軟骨関連疾患治療剤 |
EP1707208A4 (en) * | 2003-12-05 | 2010-03-17 | Ono Pharmaceutical Co | PROMOTER OF BLOOD FLOW IN THE TISSUES OF THE HORSE TAIL |
WO2005080367A1 (en) | 2004-02-12 | 2005-09-01 | Pharmagene Laboratories Limited | Ep2 receptor agonists |
MY158766A (en) * | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
BRPI0611079A2 (pt) | 2005-06-03 | 2010-08-03 | Ono Pharmaceutical Co | agentes para a regeneração e/ou proteção de nervos |
CA2618486A1 (en) | 2005-08-09 | 2007-02-15 | Asterand Uk Limited | Ep2 receptor agonists |
PL1976828T3 (pl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Pochodne diaminy jako inhibitory hydrolazy leukotrienu a4 |
WO2008046049A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
WO2009065070A2 (en) | 2007-11-14 | 2009-05-22 | Cayman Chemical Company | Prostaglandin e1 and e2 analogs for the treatment of various medical conditions |
EP2350091B1 (en) * | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
HUE025938T2 (en) * | 2008-10-17 | 2016-05-30 | Xenon Pharmaceuticals Inc | Spiro oxindole compounds and their use as therapeutic agents |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
PL2441760T3 (pl) | 2009-06-10 | 2014-05-30 | Ono Pharmaceutical Co | Związek o działaniu kurczącym mięsień-wypieracz i zwiotczającym mięsień-zwieracz cewki moczowej |
AR077252A1 (es) * | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
EP2488531B1 (en) * | 2009-10-14 | 2014-03-26 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
JP6195609B2 (ja) | 2012-04-12 | 2017-09-13 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | 治療剤として有用なスピロ−オキソインドール化合物の不斉合成 |
CA2882732C (en) | 2012-08-31 | 2021-03-30 | Ono Pharmaceutical Co., Ltd. | A 2-[(2-{(1r,5r)-2-oxo-5-[(1e,4s)-7,8,8-trifluoro-4-hydroxy-4-methyl-1,7-octadiene-1-yl]cyclopentyl}ethyl)thio}-1,3-thiazole-4-carboxylic acid 4-piperidinemethanol salt and crystals thereof |
KR20150127245A (ko) | 2013-03-14 | 2015-11-16 | 켈탁시스, 인코퍼레이티드 | 류코트라이엔 a4 가수분해효소의 저해제 |
EP2818484A1 (en) | 2013-06-28 | 2014-12-31 | Universitat Autònoma de Barcelona | Synergistic combination of an anti-IgE antibody and an EP2 receptor agonist |
US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
US10100060B2 (en) | 2016-06-16 | 2018-10-16 | Xenon Pharmaceuticals Inc. | Asymmetric synthesis of funapide |
RU2019119652A (ru) | 2016-12-09 | 2021-01-11 | Селтакссис, Инк. | Ингибиторы лейкотриен-а4-гидролазы |
WO2018107158A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase |
WO2018107167A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3835180A (en) * | 1971-05-04 | 1974-09-10 | Upjohn Co | 15 alkoxy pge compounds |
US3876690A (en) * | 1973-05-11 | 1975-04-08 | American Cyanamid Co | 1-alkoxy-9-keto-prostenoic acid derivatives |
GB1451798A (en) * | 1973-08-02 | 1976-10-06 | Ici Ltd | Prostanoic acid derivatives |
US4236027A (en) * | 1977-10-17 | 1980-11-25 | American Cyanamid Company | Novel 11-alkoxy-9-keto (or hydroxy)-prostenoic acid derivatives and method for preparing same |
JPS55115836A (en) * | 1979-03-02 | 1980-09-06 | Toray Ind Inc | Preparation of methyl ether derivative |
DE3510978A1 (de) * | 1985-03-22 | 1986-09-25 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPH03101622A (ja) * | 1989-09-11 | 1991-04-26 | Green Cross Corp:The | 肝炎予防治療剤 |
-
1998
- 1998-02-10 AT AT98901576T patent/ATE237587T1/de not_active IP Right Cessation
- 1998-02-10 WO PCT/JP1998/000544 patent/WO1998034916A1/ja not_active Application Discontinuation
- 1998-02-10 JP JP53414898A patent/JP4044967B2/ja not_active Expired - Lifetime
- 1998-02-10 PT PT98901576T patent/PT1008588E/pt unknown
- 1998-02-10 KR KR1019997007168A patent/KR20000070903A/ko not_active Application Discontinuation
- 1998-02-10 US US09/355,626 patent/US6288119B1/en not_active Expired - Lifetime
- 1998-02-10 DE DE69813571T patent/DE69813571T2/de not_active Expired - Fee Related
- 1998-02-10 ES ES98901576T patent/ES2196527T3/es not_active Expired - Lifetime
- 1998-02-10 EP EP98901576A patent/EP1008588B1/en not_active Expired - Lifetime
- 1998-02-10 DK DK98901576T patent/DK1008588T3/da active
Also Published As
Publication number | Publication date |
---|---|
DE69813571T2 (de) | 2004-02-12 |
ATE237587T1 (de) | 2003-05-15 |
DE69813571D1 (de) | 2003-05-22 |
WO1998034916A1 (fr) | 1998-08-13 |
KR20000070903A (ko) | 2000-11-25 |
DK1008588T3 (da) | 2003-07-28 |
EP1008588A4 (en) | 2000-06-14 |
ES2196527T3 (es) | 2003-12-16 |
JP4044967B2 (ja) | 2008-02-06 |
US6288119B1 (en) | 2001-09-11 |
EP1008588A1 (en) | 2000-06-14 |
EP1008588B1 (en) | 2003-04-16 |
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