MX2014000338A - Derivados de pirrolo-pirimidina novedoso. - Google Patents
Derivados de pirrolo-pirimidina novedoso.Info
- Publication number
- MX2014000338A MX2014000338A MX2014000338A MX2014000338A MX2014000338A MX 2014000338 A MX2014000338 A MX 2014000338A MX 2014000338 A MX2014000338 A MX 2014000338A MX 2014000338 A MX2014000338 A MX 2014000338A MX 2014000338 A MX2014000338 A MX 2014000338A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidine derivatives
- diseases
- novel pyrrolo
- pyrrolo pyrimidine
- novel
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente invención describe nuevos derivados de pirrolo-pirimidina y las sales farmacéuticamente aceptables de los mismos, los cuales parecen interactuar con la cinasa de tirosina de Bruton (Btk). De conformidad con lo anterior, las pirrolo-pirimidinas novedosas pueden ser efectivas en el tratamiento de los trastornos autoinmunitarios, enfermedades inflamatorias, enfermedades alérgicas, enfermedades de las vias respiratorias, tales como asma y la enfermedad pulmonar obstructiva crónica (CQPD), rechazo de trasplante, cánceres, por ejemplo, de origen hematopoiético, o tumores sólidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161505560P | 2011-07-08 | 2011-07-08 | |
PCT/IB2012/001699 WO2013008095A1 (en) | 2011-07-08 | 2012-07-07 | Novel pyrrolo pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2014000338A true MX2014000338A (es) | 2014-05-01 |
Family
ID=46880751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014000338A MX2014000338A (es) | 2011-07-08 | 2012-07-07 | Derivados de pirrolo-pirimidina novedoso. |
Country Status (12)
Country | Link |
---|---|
US (1) | US9233111B2 (es) |
EP (1) | EP2729466B1 (es) |
JP (1) | JP6145451B2 (es) |
KR (1) | KR20140058543A (es) |
CN (1) | CN103732596B (es) |
AU (1) | AU2012282229B2 (es) |
BR (1) | BR112014000314A2 (es) |
CA (1) | CA2841111A1 (es) |
EA (1) | EA201490229A1 (es) |
ES (1) | ES2548414T3 (es) |
MX (1) | MX2014000338A (es) |
WO (1) | WO2013008095A1 (es) |
Families Citing this family (50)
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AU2013293087B2 (en) | 2012-07-24 | 2017-08-31 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK) |
DK2989106T3 (en) | 2013-04-25 | 2017-03-20 | Beigene Ltd | CONDENSED HETEROCYCLIC COMPOUNDS AS PROTEINKINASE INHIBITORS |
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US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
MX2016006955A (es) * | 2013-12-02 | 2016-09-07 | Pharmacyclics Llc | Metodos para tratar y evitar enfermedad cronica de injerto versus anfitrion impulsada por aloanticuerpo. |
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-
2012
- 2012-07-07 JP JP2014517980A patent/JP6145451B2/ja not_active Expired - Fee Related
- 2012-07-07 EA EA201490229A patent/EA201490229A1/ru unknown
- 2012-07-07 KR KR1020147002986A patent/KR20140058543A/ko not_active Application Discontinuation
- 2012-07-07 CN CN201280033935.9A patent/CN103732596B/zh active Active
- 2012-07-07 AU AU2012282229A patent/AU2012282229B2/en not_active Expired - Fee Related
- 2012-07-07 MX MX2014000338A patent/MX2014000338A/es unknown
- 2012-07-07 WO PCT/IB2012/001699 patent/WO2013008095A1/en active Application Filing
- 2012-07-07 BR BR112014000314A patent/BR112014000314A2/pt not_active IP Right Cessation
- 2012-07-07 EP EP12761655.5A patent/EP2729466B1/en active Active
- 2012-07-07 US US14/130,536 patent/US9233111B2/en not_active Expired - Fee Related
- 2012-07-07 CA CA2841111A patent/CA2841111A1/en not_active Abandoned
- 2012-07-07 ES ES12761655.5T patent/ES2548414T3/es active Active
Also Published As
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KR20140058543A (ko) | 2014-05-14 |
CN103732596A (zh) | 2014-04-16 |
CN103732596B (zh) | 2016-06-01 |
CA2841111A1 (en) | 2013-01-17 |
WO2013008095A1 (en) | 2013-01-17 |
JP2014520793A (ja) | 2014-08-25 |
US9233111B2 (en) | 2016-01-12 |
JP6145451B2 (ja) | 2017-06-14 |
EA201490229A1 (ru) | 2014-05-30 |
AU2012282229A1 (en) | 2014-01-16 |
ES2548414T3 (es) | 2015-10-16 |
AU2012282229B2 (en) | 2015-05-07 |
US20140243306A1 (en) | 2014-08-28 |
EP2729466B1 (en) | 2015-08-19 |
EP2729466A1 (en) | 2014-05-14 |
BR112014000314A2 (pt) | 2017-01-10 |
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