MX2011012632A - Inhibidores de actividad de cinasa tipo pirimidina. - Google Patents
Inhibidores de actividad de cinasa tipo pirimidina.Info
- Publication number
- MX2011012632A MX2011012632A MX2011012632A MX2011012632A MX2011012632A MX 2011012632 A MX2011012632 A MX 2011012632A MX 2011012632 A MX2011012632 A MX 2011012632A MX 2011012632 A MX2011012632 A MX 2011012632A MX 2011012632 A MX2011012632 A MX 2011012632A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- kinase activity
- compounds
- pyrimidine inhibitors
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
En la presente solicitud se describen compuestos de la fórmula (I) o sales o solvatos farmacéuticamente aceptables de los mismos, en la cual L1, R2, R3, R4, R5, y m se definen en la descripción. También se describen métodos para elaborar dichos compuestos, y composiciones que comprenden dichos compuestos los cuales son útiles para inhibir cinasas tales como IGF-IR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18154509P | 2009-05-27 | 2009-05-27 | |
PCT/US2010/036187 WO2010138578A1 (en) | 2009-05-27 | 2010-05-26 | Pyrimidine inhibitors of kinase activity |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011012632A true MX2011012632A (es) | 2012-03-06 |
Family
ID=42340681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011012632A MX2011012632A (es) | 2009-05-27 | 2010-05-26 | Inhibidores de actividad de cinasa tipo pirimidina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US8486933B2 (es) |
EP (1) | EP2435422B1 (es) |
JP (1) | JP2012528177A (es) |
CN (1) | CN102459236B (es) |
CA (1) | CA2763633A1 (es) |
MX (1) | MX2011012632A (es) |
WO (1) | WO2010138578A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101695327B1 (ko) | 2008-11-07 | 2017-01-11 | 암젠 리서치 (뮌헨) 게엠베하 | 급성 림프구성 백혈병의 치료방법 |
JP5798036B2 (ja) * | 2008-11-07 | 2015-10-21 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 小児急性リンパ芽球性白血病の新規治療 |
MX2015005798A (es) * | 2012-11-07 | 2015-09-23 | Novartis Ag | Terapia de combinacion. |
AR096654A1 (es) * | 2013-06-20 | 2016-01-27 | Ab Science | Derivados de benzimidazol como inhibidores selectivos de proteína quinasa |
CN105622520A (zh) * | 2014-08-25 | 2016-06-01 | 上海博悦生物科技有限公司 | 一种治疗非小细胞肺癌药物色瑞替尼(Ceritinib)的新中间体及其制备方法 |
CN104803925B (zh) * | 2015-04-16 | 2018-01-12 | 温州医科大学 | 一类以fgfr为靶点的2,4,5‑三取代嘧啶类化合物及其制备方法和用途 |
CZ2015613A3 (cs) | 2015-09-09 | 2017-03-22 | Zentiva, K.S. | Způsob přípravy Ceritinibu |
JP6740452B2 (ja) | 2016-07-26 | 2020-08-12 | 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Shenzhen TargetRx,Inc. | プロテインチロシンキナーゼの活性を阻害するためのアミノピリミジン系化合物 |
CN109516977B (zh) * | 2019-01-23 | 2020-01-10 | 长治学院 | 一种苯胺嘧啶/喹啉杂合物、制备方法及医药用途 |
CN111004221B (zh) * | 2019-12-13 | 2021-02-02 | 长治学院 | 一种嘧啶/苯并咪唑杂合物、制备方法及医药用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003511378A (ja) * | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | トリアジン系キナーゼ阻害薬 |
US6939874B2 (en) * | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
DE60314500T2 (de) * | 2002-03-01 | 2008-02-07 | Smithkline Beecham Corp. | Diaminopyrimidine und deren verwendung als angiogenesehemmer |
GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
ATE519759T1 (de) * | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
WO2006129100A1 (en) * | 2005-06-03 | 2006-12-07 | Glaxo Group Limited | Novel compounds |
MX2009006081A (es) * | 2006-12-08 | 2009-06-17 | Irmc Llc | Compuestos y composiciones como inhibidores de cinasa de proteina. |
WO2009032668A2 (en) * | 2007-08-28 | 2009-03-12 | Irm Llc | 2 -biphenylamino-4 -aminopyrimidine derivatives as kinase inhibitors |
-
2010
- 2010-05-26 US US12/787,735 patent/US8486933B2/en not_active Expired - Fee Related
- 2010-05-26 WO PCT/US2010/036187 patent/WO2010138578A1/en active Application Filing
- 2010-05-26 EP EP10726735.3A patent/EP2435422B1/en not_active Not-in-force
- 2010-05-26 CN CN201080033863.9A patent/CN102459236B/zh not_active Expired - Fee Related
- 2010-05-26 CA CA2763633A patent/CA2763633A1/en not_active Abandoned
- 2010-05-26 JP JP2012513204A patent/JP2012528177A/ja active Pending
- 2010-05-26 MX MX2011012632A patent/MX2011012632A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO2010138578A1 (en) | 2010-12-02 |
EP2435422B1 (en) | 2014-12-17 |
CN102459236A (zh) | 2012-05-16 |
US8486933B2 (en) | 2013-07-16 |
CN102459236B (zh) | 2014-10-29 |
CA2763633A1 (en) | 2010-12-02 |
US20100305112A1 (en) | 2010-12-02 |
JP2012528177A (ja) | 2012-11-12 |
EP2435422A1 (en) | 2012-04-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: ABBVIE INC. |
|
FG | Grant or registration |