MX2011011534A - Indazoles sustituidos por oxazol como inhibidores de cinasa pi3. - Google Patents

Indazoles sustituidos por oxazol como inhibidores de cinasa pi3.

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Publication number
MX2011011534A
MX2011011534A MX2011011534A MX2011011534A MX2011011534A MX 2011011534 A MX2011011534 A MX 2011011534A MX 2011011534 A MX2011011534 A MX 2011011534A MX 2011011534 A MX2011011534 A MX 2011011534A MX 2011011534 A MX2011011534 A MX 2011011534A
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
substituted indazoles
oxazole substituted
oxazole
compounds
Prior art date
Application number
MX2011011534A
Other languages
English (en)
Inventor
Julie Nicole Hamblin
Paul Spencer Jones
Charlotte Jane Mitchell
Nigel James Parr
Suzanne Elaine Keeling
Joelle Le
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MX2011011534A publication Critical patent/MX2011011534A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Abstract

La invención se refiere a ciertos compuestos novedosos. Específicamente, la invención se refiere a compuestos de la fórmula (I) (ver fórmula (I)) y a sus sales. Los compuestos de la invención son inhibidores de la actividad de cinasa, en particular de la actividad de la cinasa-PI3.
MX2011011534A 2009-04-30 2010-04-28 Indazoles sustituidos por oxazol como inhibidores de cinasa pi3. MX2011011534A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17403309P 2009-04-30 2009-04-30
PCT/EP2010/055666 WO2010125082A1 (en) 2009-04-30 2010-04-28 Oxazole substituted indazoles as pi3-kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2011011534A true MX2011011534A (es) 2012-02-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011534A MX2011011534A (es) 2009-04-30 2010-04-28 Indazoles sustituidos por oxazol como inhibidores de cinasa pi3.

Country Status (40)

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US (14) US8580797B2 (es)
EP (3) EP2899191B1 (es)
JP (1) JP5570589B2 (es)
KR (2) KR101679642B1 (es)
CN (1) CN102459253B (es)
AR (2) AR076435A1 (es)
AU (1) AU2010243613B2 (es)
BR (1) BRPI1016219B8 (es)
CA (1) CA2759476C (es)
CL (1) CL2011002706A1 (es)
CO (1) CO6390057A2 (es)
CR (1) CR20110603A (es)
CY (1) CY1119515T1 (es)
DK (2) DK2899191T3 (es)
DO (1) DOP2011000328A (es)
EA (1) EA021056B1 (es)
ES (3) ES2876933T3 (es)
HK (2) HK1165801A1 (es)
HR (2) HRP20150173T1 (es)
HU (1) HUE034724T2 (es)
IL (1) IL215803A (es)
JO (1) JO3025B1 (es)
LT (1) LT2899191T (es)
MA (1) MA33304B1 (es)
ME (2) ME02053B (es)
MX (1) MX2011011534A (es)
MY (1) MY160454A (es)
NZ (1) NZ596071A (es)
PE (1) PE20120321A1 (es)
PL (2) PL2424864T3 (es)
PT (2) PT2899191T (es)
RS (2) RS53830B1 (es)
SG (2) SG10201401881QA (es)
SI (2) SI2424864T1 (es)
SM (1) SMT201500043B (es)
TW (3) TWI516487B (es)
UA (1) UA101098C2 (es)
UY (1) UY32585A (es)
WO (1) WO2010125082A1 (es)
ZA (1) ZA201107878B (es)

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