MEP2208A - Postupak za pripremanje citaloprama - Google Patents
Postupak za pripremanje citalopramaInfo
- Publication number
- MEP2208A MEP2208A MEP-22/08A MEP2208A MEP2208A ME P2208 A MEP2208 A ME P2208A ME P2208 A MEP2208 A ME P2208A ME P2208 A MEP2208 A ME P2208A
- Authority
- ME
- Montenegro
- Prior art keywords
- formula
- citalopram
- compound
- preparation
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Furan Compounds (AREA)
Abstract
Opisan je postupak za pripremanje citaloprama i koji obuhvata reakciju 5-karboksiftalida i zatim sa Gringnard-ovim reagensom 4-halo-fluorofenilom i Gringnard-ovim 3-halo-N, N-dimetil-propilamin reagensom i poslije izvršenog zatvaranja prstena dobijenog jedinjenja formule XI, u jedinjenje formule IV, slijedeći pretvaranje jedinjenja formule IV u citalopram. Postupci za proizvodnju i pretvaranje jedinjenje formule IV su takođe opisani.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001231 | 2000-08-18 | ||
PCT/DK2001/000542 WO2002016342A1 (en) | 2000-08-18 | 2001-08-14 | Method for the preparation of citalopram |
Publications (1)
Publication Number | Publication Date |
---|---|
MEP2208A true MEP2208A (xx) | 2010-02-10 |
Family
ID=8159660
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-23/08A MEP2308A (xx) | 2000-08-18 | 2001-08-14 | Postupak za pripremanje citaloprama |
MEP-22/08A MEP2208A (xx) | 2000-08-18 | 2001-08-14 | Postupak za pripremanje citaloprama |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-23/08A MEP2308A (xx) | 2000-08-18 | 2001-08-14 | Postupak za pripremanje citaloprama |
Country Status (41)
Country | Link |
---|---|
US (2) | US6509483B2 (bs) |
EP (2) | EP1309581B1 (bs) |
JP (2) | JP2004506730A (bs) |
KR (2) | KR100887206B1 (bs) |
CN (3) | CN1159307C (bs) |
AR (3) | AR029598A1 (bs) |
AT (4) | ATE281447T1 (bs) |
AU (6) | AU2001279608B2 (bs) |
BE (2) | BE1013443A6 (bs) |
BG (2) | BG65965B1 (bs) |
CA (2) | CA2354880C (bs) |
CH (2) | CH691968A5 (bs) |
CL (2) | CL2008002412A1 (bs) |
CZ (2) | CZ294746B6 (bs) |
DE (4) | DE60106933T2 (bs) |
DK (4) | DK1309582T3 (bs) |
EA (2) | EA005946B1 (bs) |
ES (4) | ES2230347T3 (bs) |
FI (2) | FI20011621A (bs) |
FR (2) | FR2813078B1 (bs) |
GB (2) | GB2362647B (bs) |
GR (1) | GR1004074B (bs) |
HK (3) | HK1044538B (bs) |
HR (2) | HRP20030064A2 (bs) |
HU (2) | HUP0103291A3 (bs) |
IE (2) | IES20010761A2 (bs) |
IL (2) | IL144816A (bs) |
IS (2) | IS2121B (bs) |
ME (2) | MEP2308A (bs) |
MX (2) | MXPA03001329A (bs) |
NL (2) | NL1018776C1 (bs) |
NO (2) | NO326772B1 (bs) |
NZ (2) | NZ523877A (bs) |
PL (2) | PL359825A1 (bs) |
PT (2) | PT1309582E (bs) |
RS (2) | RS50258B (bs) |
SI (2) | SI1309582T1 (bs) |
SK (2) | SK287236B6 (bs) |
UA (2) | UA72340C2 (bs) |
WO (2) | WO2002016342A1 (bs) |
ZA (1) | ZA200106683B (bs) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
ATE237604T1 (de) * | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
DE19983836C1 (de) | 1999-10-25 | 2003-10-23 | Lundbeck As Valby H | Verfahren zur Herstellung von Citalopram, 4-[1-(4- Fluorphenyl)-methanoyl]-benzonitril-Derivate und Verfahren zu deren Herstellung und deren Verwendung |
AR026063A1 (es) | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
EA004742B1 (ru) | 1999-12-28 | 2004-08-26 | Х.Лундбекк А/С | Способ получения циталопрама |
JP2003519218A (ja) | 1999-12-30 | 2003-06-17 | ハー・ルンドベック・アクチエゼルスカベット | シタロプラムの製造方法 |
SI1254129T1 (en) * | 2000-01-14 | 2004-02-29 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
NL1017417C1 (nl) | 2000-03-03 | 2001-03-16 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
CN1429219A (zh) | 2000-03-13 | 2003-07-09 | H·隆德贝克有限公司 | 制备西酞普兰的方法 |
NL1017500C1 (nl) | 2000-03-13 | 2001-04-26 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
NZ521204A (en) * | 2000-03-13 | 2004-03-26 | H | Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant |
WO2001068630A1 (en) | 2000-03-14 | 2001-09-20 | H. Lundbeck A/S | Method for the preparation of citalopram |
TR200202168T2 (tr) * | 2000-03-16 | 2002-12-23 | H. Lundbeck A/S | 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
IL144816A (en) | 2000-08-18 | 2005-09-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
SG167655A1 (en) | 2000-12-22 | 2011-01-28 | Lundbeck & Co As H | Method for the preparation of pure citalopram |
WO2003057132A2 (en) * | 2002-01-07 | 2003-07-17 | Sun Pharmaceutical Industries Limited | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile |
AR040970A1 (es) * | 2002-08-12 | 2005-04-27 | Lundbeck & Co As H | Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram |
TR200504022T1 (tr) * | 2003-03-24 | 2006-08-21 | Hetero Drugs Limited | (S)-sitalopram oksalatın yeni sıvı kristal formları. |
US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
US9339500B2 (en) * | 2008-03-04 | 2016-05-17 | Intra-Cellular Therapies, Inc. | Methods of treating vasomotor symptoms |
US20100087664A1 (en) * | 2008-10-07 | 2010-04-08 | Ravindra Vedantham | Preparation of citalopram and salts thereof |
JP6222973B2 (ja) * | 2013-04-19 | 2017-11-01 | 日本テルペン化学株式会社 | ジベンジルトリチオカーボネート誘導体 |
CN103936702A (zh) * | 2014-05-07 | 2014-07-23 | 成都诺维尔生物医药有限公司 | 艾司西酞普兰杂质j的合成方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1143702A (bs) | 1965-03-18 | |||
GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
DE3926765A1 (de) | 1989-08-12 | 1991-02-14 | Hoechst Ag | Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin |
US5296507A (en) | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
DK213290D0 (da) | 1990-09-06 | 1990-09-06 | Lundbeck & Co As H | Treatment of cerebrovascular disorders |
DE19626659A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
DE19627697A1 (de) | 1996-07-10 | 1998-01-15 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
ES2148120T3 (es) | 1997-07-08 | 2002-01-16 | Lundbeck & Co As H | Metodo para la preparacion de citalopram. |
UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
ES2149734T3 (es) | 1997-11-11 | 2003-02-16 | Lundbeck & Co As H | Metodo para la preparacion de citalopram. |
CN1129592C (zh) | 1998-10-20 | 2003-12-03 | H·隆德贝克有限公司 | 制备西酞普兰的方法 |
SI1140886T1 (en) | 1998-12-23 | 2003-08-31 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
EP1228056B1 (en) | 1999-10-25 | 2004-09-22 | H. Lundbeck A/S | Method for the preparation of citalopram |
US6310222B1 (en) | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
NL1017415C1 (nl) | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
IES20010143A2 (en) | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
GB0005477D0 (en) * | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
IL144816A (en) | 2000-08-18 | 2005-09-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
SG167655A1 (en) | 2000-12-22 | 2011-01-28 | Lundbeck & Co As H | Method for the preparation of pure citalopram |
JP2003519121A (ja) | 2000-12-28 | 2003-06-17 | ハー・ルンドベック・アクチエゼルスカベット | 純粋なシタロプラムの製造方法 |
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2001
- 2001-08-09 IL IL14481601A patent/IL144816A/xx not_active IP Right Cessation
- 2001-08-09 FI FI20011621A patent/FI20011621A/fi unknown
- 2001-08-09 CA CA002354880A patent/CA2354880C/en not_active Expired - Fee Related
- 2001-08-09 CA CA002354877A patent/CA2354877C/en not_active Expired - Fee Related
- 2001-08-09 FI FI20011622A patent/FI20011622A/fi unknown
- 2001-08-09 IL IL14481701A patent/IL144817A0/xx not_active IP Right Cessation
- 2001-08-10 IS IS6048A patent/IS2121B/is unknown
- 2001-08-10 IS IS6047A patent/IS2120B/is unknown
- 2001-08-10 HU HU0103291A patent/HUP0103291A3/hu unknown
- 2001-08-13 IE IE20010761A patent/IES20010761A2/en not_active IP Right Cessation
- 2001-08-13 IE IE20010760A patent/IES20010760A2/en not_active IP Right Cessation
- 2001-08-13 HU HU0103295A patent/HUP0103295A3/hu unknown
- 2001-08-14 JP JP2002521443A patent/JP2004506730A/ja not_active Withdrawn
- 2001-08-14 NO NO20013942A patent/NO326772B1/no not_active IP Right Cessation
- 2001-08-14 ME MEP-23/08A patent/MEP2308A/xx unknown
- 2001-08-14 NO NO20013943A patent/NO326570B1/no not_active IP Right Cessation
- 2001-08-14 EP EP01957785A patent/EP1309581B1/en not_active Expired - Lifetime
- 2001-08-14 SI SI200130272T patent/SI1309582T1/xx unknown
- 2001-08-14 ME MEP-22/08A patent/MEP2208A/xx unknown
- 2001-08-14 DK DK01957786T patent/DK1309582T3/da active
- 2001-08-14 AU AU2001279608A patent/AU2001279608B2/en not_active Ceased
- 2001-08-14 DK DK200101219A patent/DK200101219A/da not_active Application Discontinuation
- 2001-08-14 AT AT01957785T patent/ATE281447T1/de not_active IP Right Cessation
- 2001-08-14 DK DK200101216A patent/DK200101216A/da not_active Application Discontinuation
- 2001-08-14 PL PL35982501A patent/PL359825A1/xx not_active Application Discontinuation
- 2001-08-14 ES ES01957785T patent/ES2230347T3/es not_active Expired - Lifetime
- 2001-08-14 RS YU6903A patent/RS50258B/sr unknown
- 2001-08-14 UA UA2003010797A patent/UA72340C2/uk unknown
- 2001-08-14 PT PT01957786T patent/PT1309582E/pt unknown
- 2001-08-14 EA EA200300279A patent/EA005946B1/ru not_active IP Right Cessation
- 2001-08-14 DK DK01957785T patent/DK1309581T3/da active
- 2001-08-14 WO PCT/DK2001/000542 patent/WO2002016342A1/en active IP Right Grant
- 2001-08-14 KR KR1020037002005A patent/KR100887206B1/ko not_active IP Right Cessation
- 2001-08-14 AT AT01957786T patent/ATE281448T1/de not_active IP Right Cessation
- 2001-08-14 UA UA2003010798A patent/UA71676C2/uk unknown
- 2001-08-14 MX MXPA03001329A patent/MXPA03001329A/es active IP Right Grant
- 2001-08-14 ES ES01957786T patent/ES2228920T3/es not_active Expired - Lifetime
- 2001-08-14 DE DE60106933T patent/DE60106933T2/de not_active Expired - Lifetime
- 2001-08-14 SI SI200130273T patent/SI1309581T1/xx unknown
- 2001-08-14 GR GR20010100398A patent/GR1004074B/el unknown
- 2001-08-14 KR KR1020037001900A patent/KR100887207B1/ko not_active IP Right Cessation
- 2001-08-14 NZ NZ523877A patent/NZ523877A/en unknown
- 2001-08-14 DE DE60106932T patent/DE60106932T2/de not_active Expired - Lifetime
- 2001-08-14 GB GB0119733A patent/GB2362647B/en not_active Expired - Fee Related
- 2001-08-14 JP JP2002521442A patent/JP2004506729A/ja not_active Withdrawn
- 2001-08-14 GB GB0119734A patent/GB2365865B/en not_active Expired - Fee Related
- 2001-08-14 AU AU7960901A patent/AU7960901A/xx active Pending
- 2001-08-14 PL PL35996901A patent/PL359969A1/xx not_active Application Discontinuation
- 2001-08-14 PT PT01957785T patent/PT1309581E/pt unknown
- 2001-08-14 AU AU2001279609A patent/AU2001279609B2/en not_active Ceased
- 2001-08-14 ZA ZA200106683A patent/ZA200106683B/xx unknown
- 2001-08-14 RS YUP-115/03A patent/RS50287B/sr unknown
- 2001-08-14 EP EP01957786A patent/EP1309582B1/en not_active Expired - Lifetime
- 2001-08-14 AU AU7960801A patent/AU7960801A/xx active Pending
- 2001-08-14 US US09/930,110 patent/US6509483B2/en not_active Expired - Fee Related
- 2001-08-14 WO PCT/DK2001/000541 patent/WO2002016341A1/en active IP Right Grant
- 2001-08-14 US US09/930,107 patent/US6426422B1/en not_active Expired - Fee Related
- 2001-08-14 MX MXPA03000913A patent/MXPA03000913A/es active IP Right Grant
- 2001-08-14 SK SK320-2003A patent/SK287236B6/sk not_active IP Right Cessation
- 2001-08-14 NZ NZ523853A patent/NZ523853A/en unknown
- 2001-08-14 EA EA200300277A patent/EA005811B1/ru not_active IP Right Cessation
- 2001-08-14 SK SK322-2003A patent/SK287008B6/sk not_active IP Right Cessation
- 2001-08-15 CZ CZ20012958A patent/CZ294746B6/cs not_active IP Right Cessation
- 2001-08-15 AU AU2001100271A patent/AU2001100271B4/en not_active Expired
- 2001-08-15 CZ CZ20012959A patent/CZ295863B6/cs not_active IP Right Cessation
- 2001-08-16 AU AU2001100278A patent/AU2001100278B4/en not_active Expired
- 2001-08-16 BE BE2001/0548A patent/BE1013443A6/fr not_active IP Right Cessation
- 2001-08-16 DE DE10140028A patent/DE10140028A1/de not_active Withdrawn
- 2001-08-16 AR ARP010103924A patent/AR029598A1/es not_active Application Discontinuation
- 2001-08-16 DE DE10140029A patent/DE10140029A1/de not_active Withdrawn
- 2001-08-16 CH CH01521/01A patent/CH691968A5/de not_active IP Right Cessation
- 2001-08-16 FR FR0110857A patent/FR2813078B1/fr not_active Expired - Fee Related
- 2001-08-16 NL NL1018776A patent/NL1018776C1/nl not_active IP Right Cessation
- 2001-08-16 NL NL1018775A patent/NL1018775C1/nl not_active IP Right Cessation
- 2001-08-16 AR ARP010103923A patent/AR029597A1/es not_active Application Discontinuation
- 2001-08-16 FR FR0110855A patent/FR2813077B1/fr not_active Expired - Fee Related
- 2001-08-16 CH CH01522/01A patent/CH691969A5/de not_active IP Right Cessation
- 2001-08-17 CN CNB011339470A patent/CN1159307C/zh not_active Expired - Fee Related
- 2001-08-17 ES ES200101920A patent/ES2170735B2/es not_active Expired - Fee Related
- 2001-08-17 CN CNB2004100018711A patent/CN1239490C/zh not_active Expired - Fee Related
- 2001-08-17 ES ES200101919A patent/ES2170734B2/es not_active Expired - Fee Related
- 2001-08-17 CN CNB011339489A patent/CN1222517C/zh not_active Expired - Fee Related
- 2001-08-17 AT AT0065001U patent/AT4946U1/de not_active IP Right Cessation
- 2001-08-17 AT AT0065101U patent/AT5026U1/de not_active IP Right Cessation
- 2001-08-20 BE BE2001/0550A patent/BE1013444A6/fr not_active IP Right Cessation
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2002
- 2002-08-22 HK HK02106176.1A patent/HK1044538B/zh not_active IP Right Cessation
- 2002-09-04 HK HK05100254A patent/HK1068069A1/xx not_active IP Right Cessation
- 2002-09-04 HK HK02106522.2A patent/HK1047086B/zh not_active IP Right Cessation
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2003
- 2003-02-03 HR HR20030064A patent/HRP20030064A2/xx not_active Application Discontinuation
- 2003-02-03 HR HR20030065A patent/HRP20030065A2/xx not_active Application Discontinuation
- 2003-02-24 BG BG107584A patent/BG65965B1/bg unknown
- 2003-02-24 BG BG107583A patent/BG65964B1/bg unknown
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2008
- 2008-04-25 AR ARP080101772A patent/AR066694A2/es unknown
- 2008-08-14 CL CL2008002412A patent/CL2008002412A1/es unknown
- 2008-09-09 CL CL2008002673A patent/CL2008002673A1/es unknown
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