GR20010100397A - Μεθοδος παρασκευης της σιταλοπραμης. - Google Patents
Μεθοδος παρασκευης της σιταλοπραμης.Info
- Publication number
- GR20010100397A GR20010100397A GR20010100397A GR2001100397A GR20010100397A GR 20010100397 A GR20010100397 A GR 20010100397A GR 20010100397 A GR20010100397 A GR 20010100397A GR 2001100397 A GR2001100397 A GR 2001100397A GR 20010100397 A GR20010100397 A GR 20010100397A
- Authority
- GR
- Greece
- Prior art keywords
- formula
- citalopram
- compound
- preparation
- halo
- Prior art date
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
ποκαλύπτεται μία μέθοδος παρασκευής της σιταλοπράμης περιλαμβάνουσα την αντίδραση 5-καρβοξυφθαλιδίου διαδοχικά με ένα αντιδραστήριο Grignard του 4-αλογονο-φθοροφαινυλίου και ένα αντιδραστήριο Grignard της 3-αλογονο-Ν,Ν-διμεθυλ-προπυλ-αμίνης και εν συνεχεία την πραγματοποίηση κλεισίματος δακτυλίου της προκυπτούσης ενώσεως Τύπου ΧΙ προς μία ένωση Τύπου IV ακολουθούμενη από μετατροπή της ενώσεως Τύπου IV σε σιταλοπράμη. Αποκαλύπτονται επίσης μέθοδοι για την παρασκευή και τη μετατροπή της ενώσεως Τύπου IV. ΰ
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20010100397A GR1004635B (el) | 2001-08-14 | 2001-08-14 | Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GR20010100397A GR1004635B (el) | 2001-08-14 | 2001-08-14 | Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα |
Publications (2)
Publication Number | Publication Date |
---|---|
GR20010100397A true GR20010100397A (el) | 2002-05-24 |
GR1004635B GR1004635B (el) | 2004-07-14 |
Family
ID=10944802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20010100397A GR1004635B (el) | 2001-08-14 | 2001-08-14 | Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα |
Country Status (1)
Country | Link |
---|---|
GR (1) | GR1004635B (el) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998019513A2 (en) * | 1997-07-08 | 1998-05-14 | H. Lundbeck A/S | Method for the preparation of citalopram |
WO2000044738A1 (en) * | 1999-01-29 | 2000-08-03 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
-
2001
- 2001-08-14 GR GR20010100397A patent/GR1004635B/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998019513A2 (en) * | 1997-07-08 | 1998-05-14 | H. Lundbeck A/S | Method for the preparation of citalopram |
WO2000044738A1 (en) * | 1999-01-29 | 2000-08-03 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
Also Published As
Publication number | Publication date |
---|---|
GR1004635B (el) | 2004-07-14 |
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