MA39301A1 - Insuline à action prolongée et utilisation associée - Google Patents
Insuline à action prolongée et utilisation associéeInfo
- Publication number
- MA39301A1 MA39301A1 MA39301A MA39301A MA39301A1 MA 39301 A1 MA39301 A1 MA 39301A1 MA 39301 A MA39301 A MA 39301A MA 39301 A MA39301 A MA 39301A MA 39301 A1 MA39301 A1 MA 39301A1
- Authority
- MA
- Morocco
- Prior art keywords
- long
- insulin
- acting insulin
- associated use
- acting
- Prior art date
Links
- 102000016261 Long-Acting Insulin Human genes 0.000 title abstract 3
- 108010092217 Long-Acting Insulin Proteins 0.000 title abstract 3
- 229940100066 Long-acting insulin Drugs 0.000 title abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 102000003746 Insulin Receptor Human genes 0.000 abstract 1
- 108010001127 Insulin Receptor Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne : un analogue de l'insuline dans lequel la force de liaison au récepteur de l'insuline est réduite afin d'augmenter la demi-vie de l'insuline dans le sang ; une insuline à action prolongée utilisant celui-ci ; un complexe ; et un procédé de préparation de l'insuline à action prolongée.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140006938 | 2014-01-20 | ||
PCT/KR2015/000576 WO2015108398A1 (fr) | 2014-01-20 | 2015-01-20 | Insuline à action prolongée et utilisation associée |
Publications (1)
Publication Number | Publication Date |
---|---|
MA39301A1 true MA39301A1 (fr) | 2018-01-31 |
Family
ID=53543214
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43289A MA43289B1 (fr) | 2014-01-20 | 2015-01-20 | Insuline à action prolongée et utilisation associée |
MA46146A MA46146A1 (fr) | 2014-01-20 | 2015-01-20 | Insuline a action prolongée et utilisation associée |
MA39301A MA39301A1 (fr) | 2014-01-20 | 2015-01-20 | Insuline à action prolongée et utilisation associée |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43289A MA43289B1 (fr) | 2014-01-20 | 2015-01-20 | Insuline à action prolongée et utilisation associée |
MA46146A MA46146A1 (fr) | 2014-01-20 | 2015-01-20 | Insuline a action prolongée et utilisation associée |
Country Status (22)
Country | Link |
---|---|
US (1) | US10253082B2 (fr) |
EP (1) | EP3098235A4 (fr) |
JP (1) | JP2017505141A (fr) |
KR (1) | KR102406654B1 (fr) |
CN (2) | CN105916877A (fr) |
AU (1) | AU2015206890B2 (fr) |
BR (1) | BR112016016578A2 (fr) |
CA (1) | CA2937168A1 (fr) |
CL (1) | CL2016001844A1 (fr) |
CR (1) | CR20160376A (fr) |
DO (1) | DOP2016000176A (fr) |
EA (1) | EA201691374A1 (fr) |
EC (1) | ECSP16068524A (fr) |
IL (1) | IL246782B (fr) |
MA (3) | MA43289B1 (fr) |
MX (1) | MX369656B (fr) |
MY (1) | MY186251A (fr) |
PE (1) | PE20161153A1 (fr) |
PH (1) | PH12016501414B1 (fr) |
SG (1) | SG11201605680PA (fr) |
WO (1) | WO2015108398A1 (fr) |
ZA (1) | ZA201605626B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9828363B2 (en) | 2014-01-20 | 2017-11-28 | Cleave Biosciences, Inc. | Fused pyrimidines as inhibitors of P97 complex |
JP6484337B2 (ja) | 2014-11-21 | 2019-03-13 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | インスリン受容体部分アゴニスト |
AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
UY36870A (es) * | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
WO2017052305A1 (fr) * | 2015-09-24 | 2017-03-30 | Hanmi Pharm. Co., Ltd. | Procédé de production d'insuline |
EP3517544A4 (fr) * | 2016-09-23 | 2020-06-03 | Hanmi Pharm. Co., Ltd. | Analogue d'insuline ayant une force de liaison réduite au récepteur d'insuline et son utilisation |
CN110545849A (zh) * | 2017-02-03 | 2019-12-06 | 韩美药品株式会社 | 具有增加的持续性的生理活性物质的缀合物及其应用 |
MX2019011297A (es) * | 2017-03-23 | 2019-11-12 | Hanmi Pharm Ind Co Ltd | Complejo de analogo de insulina con afinidad reducida por el receptor de insulina y uso del mismo. |
JP2020535199A (ja) * | 2017-09-29 | 2020-12-03 | ハンミ ファーマシューティカル カンパニー リミテッド | 効力が向上した持続性タンパク質結合体 |
KR102646845B1 (ko) * | 2018-08-08 | 2024-03-14 | 주식회사 대웅제약 | 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법 |
KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
WO2020120479A1 (fr) | 2018-12-11 | 2020-06-18 | Sanofi | Liant peptidique |
EP4004028A1 (fr) * | 2019-07-31 | 2022-06-01 | Eli Lilly and Company | Analogues de la relaxine et leurs procédés d'utilisation |
IL295826A (en) | 2020-03-31 | 2022-10-01 | Hanmi Pharm Ind Co Ltd | Novel il-2 analogs that stimulate the immune system |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5175145A (en) | 1988-08-26 | 1992-12-29 | Amylin Pharmaceuticals, Inc. | Treatment of diabetes mellitus with amylin agonists |
US5422339A (en) * | 1991-03-19 | 1995-06-06 | Joslin Diabetes Center, Inc. | Peptides having insulin autoantibody but not insulin receptor binding capacity |
US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
DE69731289D1 (de) | 1996-03-18 | 2004-11-25 | Univ Texas | Immunglobulinähnliche domäne mit erhöhten halbwertszeiten |
CA2356109C (fr) | 1999-01-06 | 2008-04-22 | Genentech, Inc. | Variants mutants du facteur de croissance insulinomimetique (igf) de type i |
AR036711A1 (es) | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
BRPI0409600A (pt) * | 2003-04-29 | 2006-04-18 | Lilly Co Eli | análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina |
PL1648933T3 (pl) | 2003-07-25 | 2010-01-29 | Conjuchem Biotechnologies Inc | Długo działające pochodne insuliny i związane z tym sposoby |
ES2438098T3 (es) | 2003-11-13 | 2014-01-15 | Hanmi Science Co., Ltd. | Composición farmacéutica que comprende un Fc de inmunoglobulina como vehículo |
CN102660614A (zh) | 2005-08-16 | 2012-09-12 | 诺沃-诺迪斯克有限公司 | 制备成熟胰岛素多肽的方法 |
ES2542146T3 (es) * | 2006-07-31 | 2015-07-31 | Novo Nordisk A/S | Insulinas extendidas PEGiladas. |
WO2008049711A1 (fr) * | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Insuline à peptide ajouté |
US7790677B2 (en) | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
JP2008169195A (ja) | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
US20100216691A1 (en) | 2007-07-16 | 2010-08-26 | Novo Nordisk A/S | Protease Stabilized, Pegylated Insulin Analogues |
EP2017288A1 (fr) | 2007-07-16 | 2009-01-21 | Novo Nordisk A/S | Analogues de l'insuline pégylés, stabilisés à la protéase |
JP2009019027A (ja) | 2007-07-16 | 2009-01-29 | Hanmi Pharmaceutical Co Ltd | アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体 |
WO2009022005A1 (fr) | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Analogues de l'insuline avec une fraction acyle et alkylène glycol |
WO2009063072A2 (fr) | 2007-11-16 | 2009-05-22 | Novo Nordisk A/S | Composition pharmaceutique contenant de l'insuline et peptide insulinotropique |
DE102008003568A1 (de) | 2008-01-09 | 2009-07-16 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
PL2229407T3 (pl) | 2008-01-09 | 2017-06-30 | Sanofi-Aventis Deutschland Gmbh | Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania |
DE102008025008A1 (de) | 2008-05-24 | 2009-11-26 | Sanofi-Aventis Deutschland Gmbh | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
KR20100111683A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
WO2009112583A2 (fr) * | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Analogues de l’insuline stabilisés une protéase |
DK2910570T3 (en) * | 2008-03-18 | 2017-01-30 | Novo Nordisk As | Protease-stabilized acylated insulin analogues. |
WO2009129250A2 (fr) * | 2008-04-14 | 2009-10-22 | Case Western Reserve University | Analogues de l'insuline à prendre au moment des repas de stabilité améliorée |
AU2009305472B2 (en) | 2008-10-17 | 2013-12-19 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1 agonist |
EP2376521B1 (fr) * | 2008-12-19 | 2016-04-13 | Indiana University Research and Technology Corporation | Promédicaments insuliniques à base d'amide |
AU2009335712B2 (en) | 2008-12-19 | 2015-09-17 | Indiana University Research And Technology Corporation | Insulin analogs |
JP2012521971A (ja) | 2009-03-27 | 2012-09-20 | グラクソ グループ リミテッド | 薬物融合体および複合体 |
US20120184488A1 (en) | 2009-09-01 | 2012-07-19 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
KR101058209B1 (ko) | 2009-12-30 | 2011-08-22 | 전자부품연구원 | Ofdm 방식의 디지털 방송 시스템의 빠른 동기 방법 |
AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
KR101330868B1 (ko) | 2010-06-08 | 2013-11-18 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 인슐린 유도체 약물 결합체 |
KR101324828B1 (ko) | 2010-06-08 | 2013-11-01 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체 |
CN103068842B (zh) * | 2010-06-16 | 2016-10-19 | 印第安纳大学研究及科技有限公司 | 对胰岛素受体具有高活性的单链胰岛素激动剂 |
KR101382593B1 (ko) | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
WO2012015692A2 (fr) | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Polypeptides d'insuline exprimés de façon recombinante et utilisations de ceux-ci |
EP2665487A1 (fr) | 2011-01-20 | 2013-11-27 | Zealand Pharma A/S | Combinaison d'analogues du glucagon acylé à des analogues d'insuline |
MX346488B (es) | 2011-03-02 | 2017-03-22 | Oerlikon Surface Solutions Ag Pfäffikon | Componente deslizante recubierto con capa de carbono que comprende metal para mejorar el comportamiento de desgaste y de fricción mediante las aplicaciones tribológicas bajo las condiciones lubricadas. |
CN102675452B (zh) | 2011-03-17 | 2015-09-16 | 重庆富进生物医药有限公司 | 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物 |
RU2578641C2 (ru) | 2011-05-03 | 2016-03-27 | Тейджин Арамид Б.В. | Пуленепробиваемая панель |
BR112013030933A2 (pt) | 2011-06-02 | 2018-04-24 | Prolor Biotech Inc | agonistas do receptor de glp-1/glucágon de ação prolongada |
UA113626C2 (xx) | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
CN103732618B (zh) | 2011-06-10 | 2018-10-09 | 韩美科学株式会社 | 新型泌酸调节肽衍生物和包含该泌酸调节肽衍生物的用于治疗肥胖的药物组合物 |
SI2721062T1 (sl) | 2011-06-17 | 2019-03-29 | Hanmi Science Co., Ltd. | Konjugat, obsegajoč oksintomodulinski in imunoglobinski fragment, in uporaba le-tega |
WO2013089463A1 (fr) | 2011-12-16 | 2013-06-20 | Lg Innotek Co., Ltd. | Procédé de dépôt de carbure de silicium et tranche épitaxiale de carbure de silicium |
WO2013110069A1 (fr) | 2012-01-20 | 2013-07-25 | Case Western Reserve University | Analogues de l'insuline stabilisés par l'acide glutamique |
KR101665009B1 (ko) | 2012-03-09 | 2016-10-11 | 한미사이언스 주식회사 | 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물 |
KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
AR091902A1 (es) | 2012-07-25 | 2015-03-11 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de un conjugado de insulina de accion prolongada |
AR094821A1 (es) | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
AR092862A1 (es) | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
WO2014049610A2 (fr) | 2012-09-26 | 2014-04-03 | Cadila Healthcare Limited | Peptides en tant que triples agonistes des récepteurs de gip, glp-1 et glucagon |
MY197849A (en) | 2012-11-06 | 2023-07-20 | Hanmi Pharm Ind Co Ltd | Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment |
ES2868351T3 (es) * | 2013-02-26 | 2021-10-21 | Hanmi Pharm Ind Co Ltd | Conjugados de análogos de insulina y usos de los mismos |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
KR101676542B1 (ko) | 2014-12-30 | 2016-11-16 | 건국대학교 산학협력단 | 프로인슐린의 면역학적 용도 |
-
2015
- 2015-01-20 EP EP15737856.3A patent/EP3098235A4/fr not_active Withdrawn
- 2015-01-20 US US15/113,027 patent/US10253082B2/en active Active
- 2015-01-20 SG SG11201605680PA patent/SG11201605680PA/en unknown
- 2015-01-20 BR BR112016016578A patent/BR112016016578A2/pt not_active Application Discontinuation
- 2015-01-20 MX MX2016009434A patent/MX369656B/es active IP Right Grant
- 2015-01-20 MA MA43289A patent/MA43289B1/fr unknown
- 2015-01-20 AU AU2015206890A patent/AU2015206890B2/en not_active Ceased
- 2015-01-20 CR CR20160376A patent/CR20160376A/es unknown
- 2015-01-20 MA MA46146A patent/MA46146A1/fr unknown
- 2015-01-20 CN CN201580004573.4A patent/CN105916877A/zh active Pending
- 2015-01-20 WO PCT/KR2015/000576 patent/WO2015108398A1/fr active Application Filing
- 2015-01-20 CN CN202311024383.1A patent/CN116987172A/zh active Pending
- 2015-01-20 MA MA39301A patent/MA39301A1/fr unknown
- 2015-01-20 KR KR1020150009433A patent/KR102406654B1/ko active IP Right Grant
- 2015-01-20 EA EA201691374A patent/EA201691374A1/ru unknown
- 2015-01-20 JP JP2016564933A patent/JP2017505141A/ja active Pending
- 2015-01-20 CA CA2937168A patent/CA2937168A1/fr not_active Abandoned
- 2015-01-20 MY MYPI2016702501A patent/MY186251A/en unknown
- 2015-01-20 PE PE2016001252A patent/PE20161153A1/es unknown
-
2016
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- 2016-08-15 ZA ZA2016/05626A patent/ZA201605626B/en unknown
- 2016-08-19 EC ECIEPI201668524A patent/ECSP16068524A/es unknown
Also Published As
Publication number | Publication date |
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AU2015206890A1 (en) | 2016-08-04 |
BR112016016578A2 (pt) | 2017-10-03 |
ZA201605626B (en) | 2017-11-29 |
IL246782B (en) | 2020-01-30 |
KR102406654B1 (ko) | 2022-06-10 |
DOP2016000176A (es) | 2017-02-15 |
CL2016001844A1 (es) | 2017-01-06 |
EP3098235A4 (fr) | 2017-10-18 |
MX369656B (es) | 2019-11-15 |
WO2015108398A1 (fr) | 2015-07-23 |
PH12016501414A1 (en) | 2016-09-14 |
MY186251A (en) | 2021-06-30 |
JP2017505141A (ja) | 2017-02-16 |
MA46146A1 (fr) | 2020-12-31 |
CR20160376A (es) | 2016-10-07 |
EA201691374A1 (ru) | 2016-12-30 |
CN116987172A (zh) | 2023-11-03 |
PH12016501414B1 (en) | 2016-09-14 |
ECSP16068524A (es) | 2018-11-30 |
PE20161153A1 (es) | 2016-10-27 |
MA43289B1 (fr) | 2019-12-31 |
US20170101455A1 (en) | 2017-04-13 |
EP3098235A1 (fr) | 2016-11-30 |
AU2015206890B2 (en) | 2019-05-23 |
MX2016009434A (es) | 2017-01-18 |
KR20150087130A (ko) | 2015-07-29 |
US10253082B2 (en) | 2019-04-09 |
SG11201605680PA (en) | 2016-09-29 |
CN105916877A (zh) | 2016-08-31 |
IL246782A0 (en) | 2016-08-31 |
CA2937168A1 (fr) | 2015-07-23 |
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