UA118653C2 - Суперагоністи глікопротеїнового гормону тривалої дії - Google Patents

Суперагоністи глікопротеїнового гормону тривалої дії

Info

Publication number
UA118653C2
UA118653C2 UAA201500722A UAA201500722A UA118653C2 UA 118653 C2 UA118653 C2 UA 118653C2 UA A201500722 A UAA201500722 A UA A201500722A UA A201500722 A UAA201500722 A UA A201500722A UA 118653 C2 UA118653 C2 UA 118653C2
Authority
UA
Ukraine
Prior art keywords
glycoprotein hormone
superagonists
acting
long
hormone long
Prior art date
Application number
UAA201500722A
Other languages
English (en)
Inventor
Маріуш Шкудлінскі
Брюс Д. Уейнтрауб
Original Assignee
Трофоджен Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Трофоджен Інк. filed Critical Трофоджен Інк.
Publication of UA118653C2 publication Critical patent/UA118653C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Винахід стосується модифікованого поліпептиду бичачої альфа-субодиниці та модифікованого гліпротеїнового гормону, що містить дану альфа-субодиницю. Винахід також стосується способу стимуляції овуляції у тварин, який включає введення вказаного глікопротеїнового гормону.
UAA201500722A 2012-07-30 2013-07-29 Суперагоністи глікопротеїнового гормону тривалої дії UA118653C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261677331P 2012-07-30 2012-07-30
PCT/US2013/052510 WO2014022283A2 (en) 2012-07-30 2013-07-29 Glycoprotein hormone long-acting superagonists

Publications (1)

Publication Number Publication Date
UA118653C2 true UA118653C2 (uk) 2019-02-25

Family

ID=49995487

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201500722A UA118653C2 (uk) 2012-07-30 2013-07-29 Суперагоністи глікопротеїнового гормону тривалої дії

Country Status (21)

Country Link
US (5) US9187545B2 (uk)
EP (4) EP4012033A1 (uk)
JP (1) JP6429774B2 (uk)
CN (3) CN112409472A (uk)
AR (1) AR091936A1 (uk)
AU (2) AU2013296709B2 (uk)
BR (1) BR112015001885B1 (uk)
CA (2) CA3108181A1 (uk)
DK (2) DK3572515T3 (uk)
ES (2) ES2894135T3 (uk)
HR (1) HRP20190847T1 (uk)
HU (1) HUE044016T2 (uk)
MX (1) MX360717B (uk)
NZ (1) NZ707016A (uk)
PL (2) PL3572515T3 (uk)
PT (2) PT2880164T (uk)
RS (1) RS58881B1 (uk)
RU (2) RU2018132561A (uk)
UA (1) UA118653C2 (uk)
WO (1) WO2014022283A2 (uk)
ZA (1) ZA201502778B (uk)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112409472A (zh) 2012-07-30 2021-02-26 特洛佛根股份有限公司 糖蛋白激素长效超激动剂
US10457713B2 (en) 2012-07-30 2019-10-29 Trophogen, Inc. Glycoprotein hormone long-acting superagonists
WO2015069777A1 (en) 2013-11-05 2015-05-14 Trophogen Inc. Glycoprotein hormone long-acting superagonists
BR102015032660B1 (pt) 2015-12-28 2019-05-28 Ouro Fino Saúde Animal Participações S.A. PROCESSO DE PRODUÇÃO DE UMA GONADOTROFINA CORIÔNICA EQUINA RECOMBINANTE (reCG): COMPOSIÇÃO VETERINÁRIA E USO

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196123A (en) 1978-11-20 1980-04-01 Eugenia Rosemberg Hybrid chorionic gonadotropin preparations and methods for stimulating ovulation using same
ATE65407T1 (de) 1984-04-03 1991-08-15 Serono Lab Verfahren zur herbeifuehrung der ovulation.
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
DE3751602T2 (de) 1987-05-12 1996-05-02 Serono Pharm Praep Subkutane Verabreichung des humanen Choriongonadotropins.
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
WO1990002812A1 (en) 1988-09-01 1990-03-22 Applied Research Systems Ars Holding N.V. Methods for producing gonadotropin and tsh super-agonists
GB8901778D0 (en) 1989-01-27 1989-03-15 Univ Court Of The University O Manipulatory technique
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
EP0404458A3 (en) 1989-06-19 1992-03-04 Bunge (Australia) Proprietary Limited Ovine follicle stimulating hormone
JP3330373B2 (ja) 1990-05-08 2002-09-30 ユニバーシティー オブ メディスン アンド デンティストリー オブ ニュー ジャージー 変容免疫学的特性、性能および/またはレセプター特異性を有する糖タンパク質ホルモンの類似体
EP0555229B1 (en) 1990-07-31 1996-06-05 The Liposome Company, Inc. Accumulation of amino acids and peptides into liposomes
US5612034A (en) 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
JPH07507201A (ja) 1992-03-10 1995-08-10 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ レプリゼンテッド バイ ザ セクレタリー,デパートメント オブ ヘルス アンド ヒューマン サービシーズ 可変鋳型反応
US5604198A (en) 1994-05-12 1997-02-18 Poduslo; Joseph F. Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents
RU2213099C2 (ru) * 1994-08-12 2003-09-27 Вашингтон Юниверсити Одноцепочечный белок, модулятор гормонов лютеинизирующего, фолликулостимулирующего, тиреостимулирующего и хорионического гонадотропина (варианты), молекула нуклеиновой кислоты (варианты), вектор (варианты), линия трансформированных клеток сно (варианты), способ продуцирования одноцепочечного белка (варианты)
US6020473A (en) 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
US7005505B1 (en) 1995-08-25 2006-02-28 Genentech, Inc. Variants of vascular endothelial cell growth factor
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
DE69637375T2 (de) 1996-05-08 2009-02-12 The United States Government As Represented By The Department Of Health And Human Services Glycoprotein hormone (tsh) superagonists
US6361992B1 (en) * 1996-05-08 2002-03-26 The United States Of America As Represented By The Department Of Health And Human Services Thyroid stimulating hormone superagonists
ES2251740T3 (es) 1996-08-23 2006-05-01 Ludwig Institute For Cancer Research Factor de crecimiento de celulas de endotelio vascular d recombinante (vegf-d).
CA2267220A1 (en) 1996-10-11 1998-04-23 The Texas A & M University System Methods for the generation of primordial germ cells and transgenic animal species
US6750044B1 (en) 1996-10-17 2004-06-15 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids
US6485942B1 (en) 1997-02-14 2002-11-26 Genentech, Inc. Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production
US6080912A (en) 1997-03-20 2000-06-27 Wisconsin Alumni Research Foundation Methods for creating transgenic animals
ES2332931T3 (es) * 1997-06-25 2010-02-15 Merck Serono Sa Analogos de hormonas glicoproteinicas entrelazadas por disulfuro, su preparacion y uso.
US6281408B1 (en) 1998-02-20 2001-08-28 Thomas Jefferson University Efficient method for production of compound transgenic animals
JP2003524381A (ja) 1998-09-22 2003-08-19 ユニヴァーシティ オブ メリーランド,ボルチモア システインノット成長因子ミュータント
DE69931178T8 (de) 1998-11-02 2007-06-28 Ludwig Institute For Cancer Research Ein dem vaskularen endothelen wachstumsfaktor verwandtes protein aus orf virus nz10 bindet und aktiviert den säuger vegf rezeptor-2
CA2369262A1 (en) * 1999-04-13 2000-10-19 Sudha Nagarajan Pulmonary administration of dry powder formulations for treating infertility
EP1183352A1 (en) 1999-05-20 2002-03-06 Scios Inc. Vascular endothelial growth factor variants
US6555660B2 (en) 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US20020127652A1 (en) 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
EP1414964B1 (en) 2001-08-01 2010-03-24 University Of Bristol Vegf isoform
WO2005042575A2 (en) 2003-10-30 2005-05-12 Pharmexa A/S Method for down-regulation of vegf
WO2005044851A1 (en) * 2003-11-06 2005-05-19 Compugen Ltd. Variants of human glycoprotein hormone alpha chain: compositions and uses thereof
WO2005072417A2 (en) 2004-01-27 2005-08-11 The Ohio State University Research Foundation Vascular endothelial growth factors and methods of their use
EP1734979A4 (en) 2004-03-19 2009-09-09 Trophogen Inc FOLLICLE STIMULATING THE SUPERAGONISTS OF A HORMONE
CA2561545A1 (en) * 2004-03-31 2005-10-27 Trophogen, Inc. Human glycoprotein hormone superagonists and uses thereof
CN101067118A (zh) * 2007-04-24 2007-11-07 新疆农业科学院微生物应用研究所 一种重组牛促卵泡激素在毕赤酵母中的表达
WO2011075606A2 (en) * 2009-12-18 2011-06-23 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
CN112409472A (zh) 2012-07-30 2021-02-26 特洛佛根股份有限公司 糖蛋白激素长效超激动剂
US9905908B2 (en) 2014-01-14 2018-02-27 Luxshare Precision Industry Co., Ltd. Antenna structure with proximity sensor

Also Published As

Publication number Publication date
DK2880164T3 (da) 2019-05-20
AU2013296709A1 (en) 2015-02-19
AR091936A1 (es) 2015-03-11
RU2015103059A (ru) 2016-09-27
HRP20190847T1 (hr) 2019-09-06
PT2880164T (pt) 2019-06-05
DK3572515T3 (da) 2021-10-11
CA3108181A1 (en) 2014-02-06
ES2727659T3 (es) 2019-10-17
US9187545B2 (en) 2015-11-17
US20210054041A1 (en) 2021-02-25
CN112409472A (zh) 2021-02-26
US9249205B2 (en) 2016-02-02
RU2018132561A (ru) 2018-11-02
BR112015001885B1 (pt) 2022-08-09
CN104619846B (zh) 2020-11-03
US20140031530A1 (en) 2014-01-30
US20140371146A1 (en) 2014-12-18
EP3572515A1 (en) 2019-11-27
JP2015524819A (ja) 2015-08-27
CA2880520A1 (en) 2014-02-06
NZ707016A (en) 2017-08-25
RS58881B1 (sr) 2019-08-30
BR112015001885A2 (pt) 2017-11-07
PL2880164T3 (pl) 2019-10-31
US10766941B2 (en) 2020-09-08
PL3572515T3 (pl) 2022-04-11
HUE044016T2 (hu) 2019-09-30
US20160075751A1 (en) 2016-03-17
CA2880520C (en) 2021-02-09
EP3572515B1 (en) 2021-07-21
AU2013296709B2 (en) 2018-03-08
EP2880164A4 (en) 2016-03-09
ZA201502778B (en) 2021-09-29
CN112458096A (zh) 2021-03-09
EP2880164B1 (en) 2019-04-24
PT3572515T (pt) 2021-10-22
JP6429774B2 (ja) 2018-11-28
WO2014022283A2 (en) 2014-02-06
EP2880164A2 (en) 2015-06-10
AU2018203815B2 (en) 2019-12-12
MX2015001414A (es) 2015-09-23
ES2894135T3 (es) 2022-02-11
AU2018203815A1 (en) 2018-06-21
EP3533874A1 (en) 2019-09-04
RU2668174C2 (ru) 2018-09-26
CN104619846A (zh) 2015-05-13
US20230357345A1 (en) 2023-11-09
WO2014022283A3 (en) 2014-04-03
MX360717B (es) 2018-11-13
EP4012033A1 (en) 2022-06-15

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