PL1648933T3 - Długo działające pochodne insuliny i związane z tym sposoby - Google Patents
Długo działające pochodne insuliny i związane z tym sposobyInfo
- Publication number
- PL1648933T3 PL1648933T3 PL04801809T PL04801809T PL1648933T3 PL 1648933 T3 PL1648933 T3 PL 1648933T3 PL 04801809 T PL04801809 T PL 04801809T PL 04801809 T PL04801809 T PL 04801809T PL 1648933 T3 PL1648933 T3 PL 1648933T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- long lasting
- insulin derivatives
- insulin molecule
- lasting insulin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49011003P | 2003-07-25 | 2003-07-25 | |
US55658504P | 2004-03-25 | 2004-03-25 | |
EP04801809A EP1648933B1 (en) | 2003-07-25 | 2004-07-26 | Long lasting insulin derivatives and methods thereof |
PCT/CA2004/001409 WO2005012346A1 (en) | 2003-07-25 | 2004-07-26 | Long lasting insulin derivatives and methods thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1648933T3 true PL1648933T3 (pl) | 2010-01-29 |
Family
ID=34118817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL04801809T PL1648933T3 (pl) | 2003-07-25 | 2004-07-26 | Długo działające pochodne insuliny i związane z tym sposoby |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060241019A1 (pl) |
EP (2) | EP1648933B1 (pl) |
JP (2) | JP2007520441A (pl) |
AT (1) | ATE433994T1 (pl) |
AU (2) | AU2004261319B2 (pl) |
BR (1) | BRPI0412252A (pl) |
CA (1) | CA2526957C (pl) |
DE (1) | DE602004021603D1 (pl) |
DK (1) | DK1648933T3 (pl) |
EA (1) | EA008433B1 (pl) |
ES (1) | ES2328579T3 (pl) |
HK (1) | HK1091843A1 (pl) |
NO (1) | NO20060888L (pl) |
PL (1) | PL1648933T3 (pl) |
SI (1) | SI1648933T1 (pl) |
WO (1) | WO2005012346A1 (pl) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
PT1180121E (pt) * | 1999-05-17 | 2004-03-31 | Conjuchem Inc | Peptidos insulinotropicos de longa duracao |
WO2002066511A2 (en) * | 2001-02-16 | 2002-08-29 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
US20080171695A1 (en) | 2005-02-02 | 2008-07-17 | Novo Nordisk A/S | Insulin Derivatives |
ES2548393T3 (es) * | 2006-05-09 | 2015-10-16 | Novo Nordisk A/S | Derivado de insulina |
BRPI0717098B8 (pt) | 2006-09-22 | 2021-05-25 | Novo Nordisk As | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
US7982018B2 (en) | 2006-10-16 | 2011-07-19 | Conjuchem, Llc | Modified corticotropin releasing factor peptides and uses thereof |
US9387176B2 (en) | 2007-04-30 | 2016-07-12 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
EP2262539B1 (en) * | 2008-04-01 | 2015-07-15 | Novo Nordisk A/S | Insulin albumin conjugates |
US8940690B2 (en) * | 2009-01-28 | 2015-01-27 | National Institutes Of Health (Nih) | Synthetic conjugates and uses thereof |
CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
AU2013263349B2 (en) | 2012-05-17 | 2016-09-08 | Extend Biosciences, Inc | Carriers for improved drug delivery |
US9896496B2 (en) | 2013-10-07 | 2018-02-20 | Novo Nordisk A/S | Derivative of an insulin analogue |
CN116987172A (zh) | 2014-01-20 | 2023-11-03 | 韩美药品株式会社 | 长效胰岛素及其用途 |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
KR20160001391A (ko) * | 2014-06-27 | 2016-01-06 | 한미약품 주식회사 | 신규한 지속형 인슐린 아날로그 결합체 및 이의 용도 |
US9616109B2 (en) | 2014-10-22 | 2017-04-11 | Extend Biosciences, Inc. | Insulin vitamin D conjugates |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
HUE053863T2 (hu) | 2015-05-07 | 2021-07-28 | Codexis Inc | Penicillin-G acilázok |
UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
TWI774694B (zh) | 2016-09-23 | 2022-08-21 | 南韓商韓美藥品股份有限公司 | 具有降低對胰島素受體之親和力之胰島素類似物及其用途 |
WO2018109162A1 (en) | 2016-12-16 | 2018-06-21 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
CA3054899A1 (en) | 2017-03-23 | 2018-09-27 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
CN113855678A (zh) * | 2021-09-08 | 2021-12-31 | 武汉生命奥义生物科技有限公司 | 一种用于辅助治疗二型糖尿病的组合物 |
CN115894719B (zh) * | 2022-11-24 | 2023-10-20 | 武汉禾元生物科技股份有限公司 | 一种人血清白蛋白胰岛素偶联物及其制备方法 |
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US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
AU2003218635A1 (en) * | 2002-05-07 | 2003-11-11 | Novo Nordisk A/S | Soluble formulations comprising insulin aspart and insulin detemir |
WO2003105768A2 (en) * | 2002-06-13 | 2003-12-24 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
US20040138099A1 (en) * | 2002-11-29 | 2004-07-15 | Draeger Eberhard Kurt | Insulin administration regimens for the treatment of subjects with diabetes |
US20050065066A1 (en) * | 2002-12-20 | 2005-03-24 | Kaarsholm Niels Christian | Stabilised insulin compositions |
GB0309154D0 (en) * | 2003-01-14 | 2003-05-28 | Aventis Pharma Inc | Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia |
DK2599502T3 (en) * | 2003-04-11 | 2017-04-18 | Antriabio Inc | Process for Preparation of Site-Specific Protein Conjugates |
JO2625B1 (en) * | 2003-06-24 | 2011-11-01 | ميرك شارب اند دوم كوربوريشن | Phosphoric acid salts of dipeptidyl betidase inhibitor 4 |
JP4463814B2 (ja) * | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
EP1773878B1 (en) * | 2004-07-19 | 2015-03-04 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
JP2009533471A (ja) * | 2006-04-12 | 2009-09-17 | バイオデル, インコーポレイテッド | 即効型および長時間作用型組合せインスリン製剤 |
-
2004
- 2004-07-26 DK DK04801809T patent/DK1648933T3/da active
- 2004-07-26 EP EP04801809A patent/EP1648933B1/en not_active Revoked
- 2004-07-26 JP JP2006521357A patent/JP2007520441A/ja active Pending
- 2004-07-26 US US10/565,900 patent/US20060241019A1/en not_active Abandoned
- 2004-07-26 BR BRPI0412252-6A patent/BRPI0412252A/pt not_active IP Right Cessation
- 2004-07-26 AU AU2004261319A patent/AU2004261319B2/en not_active Ceased
- 2004-07-26 PL PL04801809T patent/PL1648933T3/pl unknown
- 2004-07-26 EA EA200600305A patent/EA008433B1/ru not_active IP Right Cessation
- 2004-07-26 WO PCT/CA2004/001409 patent/WO2005012346A1/en active Search and Examination
- 2004-07-26 SI SI200431199T patent/SI1648933T1/sl unknown
- 2004-07-26 AT AT04801809T patent/ATE433994T1/de active
- 2004-07-26 CA CA2526957A patent/CA2526957C/en not_active Expired - Fee Related
- 2004-07-26 DE DE602004021603T patent/DE602004021603D1/de not_active Expired - Lifetime
- 2004-07-26 EP EP09159269A patent/EP2085406A1/en not_active Withdrawn
- 2004-07-26 ES ES04801809T patent/ES2328579T3/es not_active Expired - Lifetime
-
2006
- 2006-02-23 NO NO20060888A patent/NO20060888L/no not_active Application Discontinuation
- 2006-10-12 HK HK06111254.2A patent/HK1091843A1/xx not_active IP Right Cessation
-
2011
- 2011-03-22 AU AU2011201278A patent/AU2011201278A1/en not_active Abandoned
- 2011-08-26 JP JP2011184958A patent/JP2012062311A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
HK1091843A1 (en) | 2007-01-26 |
SI1648933T1 (sl) | 2010-01-29 |
US20060241019A1 (en) | 2006-10-26 |
CA2526957A1 (en) | 2005-02-10 |
AU2004261319B2 (en) | 2010-12-23 |
AU2004261319A1 (en) | 2005-02-10 |
WO2005012346A1 (en) | 2005-02-10 |
EA008433B1 (ru) | 2007-06-29 |
EP2085406A1 (en) | 2009-08-05 |
ATE433994T1 (de) | 2009-07-15 |
AU2011201278A1 (en) | 2011-04-07 |
BRPI0412252A (pt) | 2006-09-19 |
JP2012062311A (ja) | 2012-03-29 |
EP1648933A4 (en) | 2007-02-28 |
ES2328579T3 (es) | 2009-11-16 |
EA200600305A1 (ru) | 2006-06-30 |
DK1648933T3 (da) | 2009-09-07 |
DE602004021603D1 (de) | 2009-07-30 |
EP1648933A1 (en) | 2006-04-26 |
JP2007520441A (ja) | 2007-07-26 |
EP1648933B1 (en) | 2009-06-17 |
NO20060888L (no) | 2006-04-25 |
CA2526957C (en) | 2011-07-12 |
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