CL2017000651A1 - Anticuerpos anti-glucagón y sus usos - Google Patents
Anticuerpos anti-glucagón y sus usosInfo
- Publication number
- CL2017000651A1 CL2017000651A1 CL2017000651A CL2017000651A CL2017000651A1 CL 2017000651 A1 CL2017000651 A1 CL 2017000651A1 CL 2017000651 A CL2017000651 A CL 2017000651A CL 2017000651 A CL2017000651 A CL 2017000651A CL 2017000651 A1 CL2017000651 A1 CL 2017000651A1
- Authority
- CL
- Chile
- Prior art keywords
- antibodies
- join
- gcg
- glucagon
- glucagon antibodies
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
Abstract
<p>LA PRESENTE INVENCIÓN PROPORCIONA ANTICUERPOS QUE SE UNEN A GLUCAGÓN Y MÉTODOS DE USO DE OS MISMOS. DE ACUERDO CON CIERTAS FORMAS DE REALIZACIÓN, LOS ANTICUERPOS DE LA INVENCIÓN SE UNEN GCG HUMANO CON ALTA AFINIDAD. LOS ANTICUERPOS DE LA INVENCIÓN PUEDEN SER ANTICUERPOS COMPLETAMENTE HUMANOS. LOS ANTICUERPOS DE LA INVENCIÓN SON ÚTILES PARA EL TRATAMIENTO DE VARIAS ENFERMEDADES O TRASTORNOS CARACTERIZADOS POR NIVELES ELEVADOS DE GLUCOSA EN SANGRE, ASÍ COMO OTROS TRASTORNOS RELACIONADOS CON EL GCG.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462050889P | 2014-09-16 | 2014-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017000651A1 true CL2017000651A1 (es) | 2017-12-15 |
Family
ID=54197130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017000651A CL2017000651A1 (es) | 2014-09-16 | 2017-03-16 | Anticuerpos anti-glucagón y sus usos |
Country Status (16)
Country | Link |
---|---|
US (2) | US9657099B2 (es) |
EP (1) | EP3194441A1 (es) |
JP (1) | JP2017533695A (es) |
KR (1) | KR20170062466A (es) |
CN (1) | CN107001461A (es) |
AU (1) | AU2015317899A1 (es) |
BR (1) | BR112017005110A2 (es) |
CA (1) | CA2960763A1 (es) |
CL (1) | CL2017000651A1 (es) |
CO (1) | CO2017002719A2 (es) |
EA (1) | EA201790377A1 (es) |
IL (1) | IL251000A0 (es) |
MX (1) | MX2017003535A (es) |
PH (1) | PH12017500402A1 (es) |
SG (1) | SG11201701711VA (es) |
WO (1) | WO2016044337A1 (es) |
Families Citing this family (43)
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AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
MX2017013807A (es) | 2015-04-30 | 2018-03-15 | Harvard College | Anticuerpos anti-proteina de union al lipido de adipocito humana (ap2) y agente de union al antigeno para tratar trastornos metabolicos. |
TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
CA3026521A1 (en) * | 2016-06-27 | 2018-01-04 | President And Fellows Of Harvard College | Compounds useful to treat metabolic disorders |
CN107586336A (zh) * | 2016-07-09 | 2018-01-16 | 复旦大学 | 针对寨卡病毒的全人源单克隆抗体及应用 |
WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
KR20190044079A (ko) * | 2016-08-30 | 2019-04-29 | 리제너론 파마슈티칼스 인코포레이티드 | 글루카곤 수용체 신호전달을 간섭함에 의한 중증 인슐린 저항성의 치료 방법 |
WO2018075792A1 (en) | 2016-10-20 | 2018-04-26 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
JP7005638B2 (ja) * | 2017-01-27 | 2022-02-04 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | グルカゴン受容体結合タンパク質及びその使用方法 |
WO2018227200A1 (en) | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders |
EP3967765A1 (en) | 2017-07-06 | 2022-03-16 | FrieslandCampina Nederland B.V. | Cell culture process for making a glycoprotein |
US20210130480A1 (en) | 2017-08-22 | 2021-05-06 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
US20190194298A1 (en) | 2017-12-22 | 2019-06-27 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
KR20200115485A (ko) | 2018-01-31 | 2020-10-07 | 리제너론 파마슈티칼스 인코포레이티드 | 약물 생성물 불순물을 특성화하기 위한 시스템 및 방법 |
TWI786265B (zh) | 2018-02-02 | 2022-12-11 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
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TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
EP3829636A1 (en) | 2018-07-27 | 2021-06-09 | NGM Biopharmaceuticals, Inc. | Use of glucagon receptor antagonists with immunotherapeutic agent |
KR20210052389A (ko) | 2018-08-27 | 2021-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 다운스트림 정제에서의 라만 분광법의 사용 |
SG11202011969WA (en) | 2018-08-30 | 2020-12-30 | Regeneron Pharma | Methods for characterizing protein complexes |
HUE061783T2 (hu) | 2019-01-16 | 2023-08-28 | Regeneron Pharma | Módszerek diszulfidkötések jellemzésére |
US20200363400A1 (en) | 2019-05-13 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | Competitive Ligand Binding Assays |
EP4034870A1 (en) | 2019-09-24 | 2022-08-03 | Regeneron Pharmaceuticals, Inc. | Systems and methods for chromatography use and regeneration |
WO2021108548A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous emulsions |
US11835527B2 (en) | 2020-01-21 | 2023-12-05 | Regeneron Pharmaceuticals, Inc. | Deglycosylation methods for electrophoresis of glycosylated proteins |
WO2022047108A1 (en) | 2020-08-31 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants |
TW202227473A (zh) * | 2020-10-23 | 2022-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Glp1-gcgr抗體融合蛋白變體及包含其的組成物 |
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CN116802212A (zh) * | 2021-01-20 | 2023-09-22 | 伊莱利利公司 | 胃泌酸调节素结合分子及其用途 |
CA3202197A1 (en) | 2021-01-20 | 2022-07-28 | Reginald Smith | Methods of improving protein titer in cell culture |
TW202246325A (zh) | 2021-03-03 | 2022-12-01 | 美商再生元醫藥公司 | 用於定量及修飾蛋白質黏度之系統及方法 |
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JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
EP3009453A1 (en) * | 2009-09-08 | 2016-04-20 | Neopharm Co., Ltd. | Antibodies against glucagon receptor and their use |
EP2679234A3 (en) | 2009-12-02 | 2014-04-23 | Amgen Inc. | Binding proteins that bind to human FGFR1C, human beta-klotho and both human FGFR1C and human beta-klotho |
JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
JP2015505828A (ja) * | 2011-12-02 | 2015-02-26 | イーライ リリー アンド カンパニー | 抗グルカゴン抗体およびその使用 |
TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
-
2015
- 2015-09-15 JP JP2017514534A patent/JP2017533695A/ja active Pending
- 2015-09-15 MX MX2017003535A patent/MX2017003535A/es unknown
- 2015-09-15 CN CN201580061778.6A patent/CN107001461A/zh active Pending
- 2015-09-15 WO PCT/US2015/050281 patent/WO2016044337A1/en active Application Filing
- 2015-09-15 US US14/855,274 patent/US9657099B2/en active Active
- 2015-09-15 SG SG11201701711VA patent/SG11201701711VA/en unknown
- 2015-09-15 AU AU2015317899A patent/AU2015317899A1/en not_active Abandoned
- 2015-09-15 EA EA201790377A patent/EA201790377A1/ru unknown
- 2015-09-15 BR BR112017005110A patent/BR112017005110A2/pt not_active Application Discontinuation
- 2015-09-15 CA CA2960763A patent/CA2960763A1/en not_active Abandoned
- 2015-09-15 KR KR1020177008897A patent/KR20170062466A/ko unknown
- 2015-09-15 EP EP15770766.2A patent/EP3194441A1/en not_active Withdrawn
-
2017
- 2017-03-03 PH PH12017500402A patent/PH12017500402A1/en unknown
- 2017-03-07 IL IL251000A patent/IL251000A0/en unknown
- 2017-03-16 CL CL2017000651A patent/CL2017000651A1/es unknown
- 2017-03-22 CO CONC2017/0002719A patent/CO2017002719A2/es unknown
- 2017-04-17 US US15/489,587 patent/US20170218065A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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MX2017003535A (es) | 2017-10-27 |
CA2960763A1 (en) | 2016-03-24 |
WO2016044337A1 (en) | 2016-03-24 |
SG11201701711VA (en) | 2017-04-27 |
CO2017002719A2 (es) | 2017-06-20 |
US20160075778A1 (en) | 2016-03-17 |
JP2017533695A (ja) | 2017-11-16 |
US20170218065A1 (en) | 2017-08-03 |
PH12017500402A1 (en) | 2017-07-17 |
AU2015317899A1 (en) | 2017-04-06 |
BR112017005110A2 (pt) | 2018-01-23 |
EA201790377A1 (ru) | 2017-08-31 |
EP3194441A1 (en) | 2017-07-26 |
US9657099B2 (en) | 2017-05-23 |
KR20170062466A (ko) | 2017-06-07 |
IL251000A0 (en) | 2017-04-30 |
CN107001461A (zh) | 2017-08-01 |
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