PE20161153A1 - Insulina de accion prolongada y uso de la misma - Google Patents

Insulina de accion prolongada y uso de la misma

Info

Publication number
PE20161153A1
PE20161153A1 PE2016001252A PE2016001252A PE20161153A1 PE 20161153 A1 PE20161153 A1 PE 20161153A1 PE 2016001252 A PE2016001252 A PE 2016001252A PE 2016001252 A PE2016001252 A PE 2016001252A PE 20161153 A1 PE20161153 A1 PE 20161153A1
Authority
PE
Peru
Prior art keywords
alanine
insulin
formula
insulin analog
long
Prior art date
Application number
PE2016001252A
Other languages
English (en)
Inventor
Sang Youn Hwang
Sung Youb Jung
Hyun Uk Kim
Sung Hee Park
Chang Ki Lim
Euh Lim Oh
Se Chang Kwon
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of PE20161153A1 publication Critical patent/PE20161153A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se refiere a un analogo de insulina que comprende una cadena A de formula 1 de la SEQ ID NO: 37 donde Xaa1 es glicina o alanina, Xaa2 es isoleucina o alanina, Xaa3 es tirosina, acido glutamico o asparagina y Xaa4 es tirosina o alanina; y una cadena B de formula 2 de la SEQ ID NO: 38 donde Xaa5 y Xaa6 son glicina o alanina, Xaa7 y Xaa8 son fenilalanina o alanina. Tambien se refiere a un conjugado de formula X-La-F, donde X es el analogo de insulina descrito anteriormente; L es un ligando tal como un peptido, un polimero, entre otros; a es 0 o un numero natural, F es un material capaz de aumentar la vida media in vivo del analogo de insulina tal como una region Fc de IgG. Dicho analogo de insulina presenta una afinidad reducida de la union al receptor de insulina con el proposito de aumentar la vida media en sangre de la insulina, siendo util como insulina de accion prolongada
PE2016001252A 2014-01-20 2015-01-20 Insulina de accion prolongada y uso de la misma PE20161153A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20140006938 2014-01-20

Publications (1)

Publication Number Publication Date
PE20161153A1 true PE20161153A1 (es) 2016-10-27

Family

ID=53543214

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016001252A PE20161153A1 (es) 2014-01-20 2015-01-20 Insulina de accion prolongada y uso de la misma

Country Status (22)

Country Link
US (1) US10253082B2 (es)
EP (1) EP3098235A4 (es)
JP (1) JP2017505141A (es)
KR (1) KR102406654B1 (es)
CN (2) CN116987172A (es)
AU (1) AU2015206890B2 (es)
BR (1) BR112016016578A2 (es)
CA (1) CA2937168A1 (es)
CL (1) CL2016001844A1 (es)
CR (1) CR20160376A (es)
DO (1) DOP2016000176A (es)
EA (1) EA201691374A1 (es)
EC (1) ECSP16068524A (es)
IL (1) IL246782B (es)
MA (3) MA46146A1 (es)
MX (1) MX369656B (es)
MY (1) MY186251A (es)
PE (1) PE20161153A1 (es)
PH (1) PH12016501414B1 (es)
SG (1) SG11201605680PA (es)
WO (1) WO2015108398A1 (es)
ZA (1) ZA201605626B (es)

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Also Published As

Publication number Publication date
MX2016009434A (es) 2017-01-18
MA46146A1 (fr) 2020-12-31
CN105916877A (zh) 2016-08-31
CL2016001844A1 (es) 2017-01-06
IL246782B (en) 2020-01-30
DOP2016000176A (es) 2017-02-15
MA39301A1 (fr) 2018-01-31
EP3098235A1 (en) 2016-11-30
AU2015206890A1 (en) 2016-08-04
ZA201605626B (en) 2017-11-29
US10253082B2 (en) 2019-04-09
CA2937168A1 (en) 2015-07-23
PH12016501414A1 (en) 2016-09-14
ECSP16068524A (es) 2018-11-30
EA201691374A1 (ru) 2016-12-30
IL246782A0 (en) 2016-08-31
US20170101455A1 (en) 2017-04-13
CR20160376A (es) 2016-10-07
EP3098235A4 (en) 2017-10-18
MX369656B (es) 2019-11-15
KR20150087130A (ko) 2015-07-29
PH12016501414B1 (en) 2016-09-14
BR112016016578A2 (pt) 2017-10-03
CN116987172A (zh) 2023-11-03
SG11201605680PA (en) 2016-09-29
KR102406654B1 (ko) 2022-06-10
JP2017505141A (ja) 2017-02-16
MA43289B1 (fr) 2019-12-31
MY186251A (en) 2021-06-30
AU2015206890B2 (en) 2019-05-23
WO2015108398A1 (ko) 2015-07-23

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