MA35016B1 - Imidazopyridazines en gtant qu'inhibiteurs de la kinase akt - Google Patents

Imidazopyridazines en gtant qu'inhibiteurs de la kinase akt

Info

Publication number
MA35016B1
MA35016B1 MA36290A MA36290A MA35016B1 MA 35016 B1 MA35016 B1 MA 35016B1 MA 36290 A MA36290 A MA 36290A MA 36290 A MA36290 A MA 36290A MA 35016 B1 MA35016 B1 MA 35016B1
Authority
MA
Morocco
Prior art keywords
imidazopyridazines
akt inhibitors
kinase akt
kinase
inhibitors
Prior art date
Application number
MA36290A
Other languages
English (en)
Inventor
Lars Bärfacker
William Johnston Scott
Andrea Hägebarth
Stuart Ince
Hartmut Rehwinkel
Oliver Politz
Roland Neuhaus
Hans Briem
Ulf Bömer
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh
Publication of MA35016B1 publication Critical patent/MA35016B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention concerne des imidazopyridazines de la formule (I) et un procédé pour leur fabrication et leur utilisation.
MA36290A 2011-04-07 2012-04-05 Imidazopyridazines en gtant qu'inhibiteurs de la kinase akt MA35016B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161472732P 2011-04-07 2011-04-07
PCT/EP2012/056300 WO2012136776A1 (fr) 2011-04-07 2012-04-05 Imidazopyridazines en tant qu'inhibiteurs de la kinase akt

Publications (1)

Publication Number Publication Date
MA35016B1 true MA35016B1 (fr) 2014-04-03

Family

ID=45953129

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36290A MA35016B1 (fr) 2011-04-07 2012-04-05 Imidazopyridazines en gtant qu'inhibiteurs de la kinase akt

Country Status (42)

Country Link
US (2) US9206185B2 (fr)
EP (1) EP2694510B1 (fr)
JP (1) JP5906303B2 (fr)
KR (1) KR20140022057A (fr)
CN (1) CN103596957B (fr)
AP (1) AP3597A (fr)
AR (1) AR087148A1 (fr)
AU (1) AU2012238589B2 (fr)
BR (1) BR112013025777A2 (fr)
CA (1) CA2832374A1 (fr)
CL (1) CL2013002878A1 (fr)
CO (1) CO6862145A2 (fr)
CR (1) CR20130515A (fr)
CU (1) CU24263B1 (fr)
CY (1) CY1117163T1 (fr)
DK (1) DK2694510T3 (fr)
DO (1) DOP2013000226A (fr)
EA (1) EA024890B1 (fr)
EC (1) ECSP13013008A (fr)
ES (1) ES2558780T3 (fr)
GT (1) GT201300238A (fr)
HR (1) HRP20160011T1 (fr)
HU (1) HUE026323T2 (fr)
IL (1) IL228567A0 (fr)
JO (1) JO3068B1 (fr)
MA (1) MA35016B1 (fr)
ME (1) ME02316B (fr)
MX (1) MX336865B (fr)
NI (1) NI201300105A (fr)
PE (1) PE20141380A1 (fr)
PL (1) PL2694510T3 (fr)
PT (1) PT2694510E (fr)
RS (1) RS54480B1 (fr)
SG (1) SG193631A1 (fr)
SI (1) SI2694510T1 (fr)
SM (1) SMT201600001B (fr)
TN (1) TN2013000400A1 (fr)
TW (1) TWI535719B (fr)
UA (1) UA111739C2 (fr)
UY (1) UY34006A (fr)
WO (1) WO2012136776A1 (fr)
ZA (1) ZA201307223B (fr)

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US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
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MX2012010115A (es) 2010-03-01 2013-02-26 Gtx Inc Compuestos para el tratamiento de cancer.
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JP6106694B2 (ja) * 2012-01-10 2017-04-05 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Ａｋｔキナーゼ阻害剤としての置換ピラゾロピリミジン類
CN104066735B (zh) * 2012-01-10 2016-08-31 拜耳知识产权有限责任公司 作为akt激酶抑制剂的取代的咪唑并吡嗪
CA2891346A1 (fr) * 2012-11-30 2014-06-05 Gossett Campbell Composition pharmaceutique comprenant du trametinib dimethylsulfoxide
CN109568312A (zh) * 2013-03-05 2019-04-05 田纳西大学研究基金会 用于治疗癌症的化合物
WO2014158467A1 (fr) * 2013-03-12 2014-10-02 Glaxosmithkline Llc Combinaison
JP2016517434A (ja) * 2013-03-14 2016-06-16 エピザイム，インコーポレイティド 癌を処置するための併用療法
CN105899512A (zh) * 2014-01-09 2016-08-24 拜耳医药股份公司 可用于治疗过度增殖性和/或血管生成疾病的酰胺基团取代的咪唑并哒嗪
US10774086B2 (en) 2016-11-28 2020-09-15 Bristol-Myers Squibb Company GSK-3 inhibitors
EP3453706A1 (fr) 2017-09-08 2019-03-13 Basf Se Composés pesticides de l'imizazole

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CN1173975C (zh) 2000-04-27 2004-11-03 山之内制药株式会社 咪唑并吡啶衍生物
JP2006520796A (ja) 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
EP1622616B1 (fr) 2003-04-24 2011-06-15 Merck Sharp & Dohme Corp. Inhibiteurs de l'activite akt
BRPI0412636A (pt) 2003-07-30 2006-09-26 S A L V A T Lab Sa imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer
ATE499364T1 (de) 2004-04-09 2011-03-15 Merck Sharp & Dohme Hemmer der akt aktivität
US7544677B2 (en) 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
WO2006021303A1 (fr) 2004-08-24 2006-03-02 Basf Aktiengesellschaft Sulfites d'imidazolium-methyle utilises comme composes de depart ausgangsverbindungen pour la production de liquides ioniques
EP1827436A4 (fr) 2004-12-15 2011-08-10 Merck Sharp & Dohme Inhibiteurs d'activite akt
JP2008540674A (ja) 2005-05-20 2008-11-20 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
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JP2012516847A (ja) 2009-02-02 2012-07-26 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
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US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
AR076936A1 (es) 2009-06-02 2011-07-20 Vitae Pharmaceuticals Inc Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
WO2011033265A1 (fr) * 2009-09-18 2011-03-24 Almac Discovery Limited Composés pharmaceutiques
ES2552841T3 (es) * 2010-07-12 2015-12-02 Bayer Intellectual Property Gmbh Imidazo[1,2-a]pirimidinas y -piridinas sustituidas
CA2806655A1 (fr) 2010-07-28 2012-02-02 Bayer Intellectual Property Gmbh Imidazo[1,2-b]pyridazines substituees
EA024890B1 (ru) * 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы

Also Published As

Publication number Publication date
HUE026323T2 (en) 2016-05-30
AU2012238589B2 (en) 2017-02-16
US20150368250A1 (en) 2015-12-24
EP2694510B1 (fr) 2015-10-14
CN103596957A (zh) 2014-02-19
PT2694510E (pt) 2016-02-08
EA024890B1 (ru) 2016-10-31
ECSP13013008A (es) 2013-12-31
PL2694510T3 (pl) 2016-03-31
ZA201307223B (en) 2014-12-23
TW201245204A (en) 2012-11-16
ME02316B (me) 2016-06-20
CU20130135A7 (es) 2014-02-28
ES2558780T3 (es) 2016-02-08
GT201300238A (es) 2015-04-06
JO3068B1 (ar) 2017-03-15
AP3597A (en) 2016-02-19
DK2694510T3 (en) 2016-01-18
CN103596957B (zh) 2016-12-07
SMT201600001B (it) 2016-02-25
CA2832374A1 (fr) 2012-10-11
RS54480B1 (en) 2016-06-30
HRP20160011T1 (hr) 2016-02-12
TN2013000400A1 (en) 2015-03-30
WO2012136776A1 (fr) 2012-10-11
CR20130515A (es) 2013-12-04
CO6862145A2 (es) 2014-02-10
US9604989B2 (en) 2017-03-28
KR20140022057A (ko) 2014-02-21
NZ616270A (en) 2015-09-25
SG193631A1 (en) 2013-11-29
JP5906303B2 (ja) 2016-04-20
CY1117163T1 (el) 2017-04-05
AP2013007215A0 (en) 2013-10-31
TWI535719B (zh) 2016-06-01
EP2694510A1 (fr) 2014-02-12
US9206185B2 (en) 2015-12-08
EA201301130A1 (ru) 2014-07-30
AR087148A1 (es) 2014-02-26
PE20141380A1 (es) 2014-10-18
UA111739C2 (uk) 2016-06-10
SI2694510T1 (sl) 2016-02-29
CU24263B1 (es) 2017-07-04
DOP2013000226A (es) 2013-11-15
MX336865B (es) 2016-02-04
IL228567A0 (en) 2013-12-31
BR112013025777A2 (pt) 2016-12-20
JP2014510127A (ja) 2014-04-24
US20140113901A1 (en) 2014-04-24
NI201300105A (es) 2014-07-14
UY34006A (es) 2012-10-31
MX2013011699A (es) 2014-01-31
CL2013002878A1 (es) 2014-05-02
AU2012238589A1 (en) 2013-11-07

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